PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28392465-12	2017	Our study showed that L-carnitine administration activated p38MAPK/Nrf2 signalling, initiating the expression of HO1 and NQO1, which have anti-apoptotic and anti-oxidative effects, respectively.	Carnitine	22-33	heme oxygenase 1	Homo sapiens	113-116	
31422179-6	2019	Moreover, the mRNA levels of Keap1, Nrf2, Maf and HO-1 indicated that l-carnitine regulated Nrf2/Keap1 activation.	Carnitine	70-81	heme oxygenase 1	Homo sapiens	50-54	
26889770-4	2016	Analysis using Nrf2 siRNA demonstrated that Nrf2 activation was involved in l-carnitine-induced HO-1 expression.	Carnitine	76-87	heme oxygenase 1	Homo sapiens	96-100	
26889770-3	2016	Our results showed that pretreatment with l-carnitine augmented Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells, although l-carnitine treatment alone had no effect on them.	Carnitine	42-53	heme oxygenase 1	Homo sapiens	117-133	
26889770-3	2016	Our results showed that pretreatment with l-carnitine augmented Nrf2 nuclear translocation, DNA binding activity and heme oxygenase-1 (HO-1) expression in H2O2-treated HL7702 cells, although l-carnitine treatment alone had no effect on them.	Carnitine	42-53	heme oxygenase 1	Homo sapiens	135-139	
26889770-8	2016	Moreover, our finding demonstrated that the induction of Nrf2 translocation and HO-1 expression by l-carnitine directly correlated with the Akt pathway because Akt inhibitor showed inhibitory effects on the Nrf2 translocation and HO-1 expression.	Carnitine	99-110	heme oxygenase 1	Homo sapiens	80-84	
26889770-8	2016	Moreover, our finding demonstrated that the induction of Nrf2 translocation and HO-1 expression by l-carnitine directly correlated with the Akt pathway because Akt inhibitor showed inhibitory effects on the Nrf2 translocation and HO-1 expression.	Carnitine	99-110	heme oxygenase 1	Homo sapiens	230-234	
16633995-5	2006	EPO cellular mechanisms are not completely known, and the identification of close biochemical and molecular relationships between EPO and heme oxygenase-1 (HO-1), which has potent antioxidant and anti-apoptotic properties, could provide the rationale for the beneficial effect of carnitine having been shown to possess antioxidant, anti-apoptotic and erythropoietic activities and to induce HO-1 expression, not only in dialysis patients who fail to respond adequately to EPO, but also in patients with heart failure.	Carnitine	280-289	heme oxygenase 1	Homo sapiens	138-154	
17199800-0	2006	Carnitine"S protective effect on oxidative stress is mediated by heme oxygenase-1.	Carnitine	0-9	heme oxygenase 1	Homo sapiens	65-81	
16337498-4	2006	RESULTS: HO-1 as well as ecNOS gene and protein expression significantly increased upon Carnitines incubation.	Carnitine	88-98	heme oxygenase 1	Homo sapiens	9-13	
16337498-9	2006	CONCLUSION: This is the first report that has utilized a molecular biological approach to demonstrate a direct stimulatory effect of Carnitines on gene and protein expression of the oxidative stress related markers HO-1 and ecNOS.	Carnitine	133-143	heme oxygenase 1	Homo sapiens	215-219	
16337498-10	2006	As HO-1 and NO are known as antioxidant, antiproliferative and anti-inflammatory, their increased expression would be expected to protect from oxidative stress related cardiovascular risk factors and myocardial damage, therefore adding this effect to the multiple pathways involved in the effects of carnitines.	Carnitine	300-310	heme oxygenase 1	Homo sapiens	3-7	
16633995-5	2006	EPO cellular mechanisms are not completely known, and the identification of close biochemical and molecular relationships between EPO and heme oxygenase-1 (HO-1), which has potent antioxidant and anti-apoptotic properties, could provide the rationale for the beneficial effect of carnitine having been shown to possess antioxidant, anti-apoptotic and erythropoietic activities and to induce HO-1 expression, not only in dialysis patients who fail to respond adequately to EPO, but also in patients with heart failure.	Carnitine	280-289	heme oxygenase 1	Homo sapiens	156-160