PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24716857-0 2014 Carnitine transporter OCTN2 and carnitine uptake in bovine kidney cells is regulated by peroxisome proliferator-activated receptor beta/delta. Carnitine 32-41 peroxisome proliferator activated receptor delta Bos taurus 88-141 24716857-2 2014 Whether PPARbeta/delta, another PPAR subtype, which has partially overlapping functions as PPARalpha and is known to share a large set of common target genes with PPARalpha, also regulates OCTN2 and carnitine transport in cattle is currently unknown. Carnitine 199-208 peroxisome proliferator activated receptor delta Bos taurus 8-16 24716857-3 2014 To close this gap of knowledge, we studied the effect of the PPARbeta/delta activator GW0742 on mRNA and protein levels of OCTN2 and carnitine uptake in the presence and absence of the PPARbeta/delta antagonist GSK3787 in the bovine Madin-Darby bovine kidney (MDBK) cell line. Carnitine 133-142 peroxisome proliferator activated receptor delta Bos taurus 61-69 24716857-6 2014 In addition, GW0742 increased Na+-dependent carnitine uptake, which is mediated by OCTN2, into MDBK cells, whereas treatment of cells with the PPARbeta/delta antagonist completely abolished the stimulatory effect of GW0742 on carnitine uptake. Carnitine 226-235 peroxisome proliferator activated receptor delta Bos taurus 143-151 24716857-7 2014 CONCLUSIONS: The present study shows for the first time that gene expression of the carnitine transporter OCTN2 and carnitine transport are regulated by PPARbeta/delta in bovine cells. Carnitine 84-93 peroxisome proliferator activated receptor delta Bos taurus 153-161