PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32781271-8 2021 Repeat acylcarnitine profile and total/free carnitine were consistent with CPT1A deficiency. Carnitine 11-20 carnitine palmitoyltransferase 1A Homo sapiens 75-80 33845545-8 2021 Detection of free carnitine and acyl carnitine by tandem mass spectrometry is helpful for early screening and diagnosis of carnitine palmitoyltransferase 1A deficiency. Carnitine 18-27 carnitine palmitoyltransferase 1A Homo sapiens 123-156 32654140-3 2021 Fatty acid oxidation (FAO) in mitochondria requires L-carnitine for the formation of acylcarnitines by carnitine palmitoylotransferase 1 (CPT1) and further transport of acyl carnitine esters to mitochondrial matrix. Carnitine 52-63 carnitine palmitoyltransferase 1A Homo sapiens 103-136 32654140-3 2021 Fatty acid oxidation (FAO) in mitochondria requires L-carnitine for the formation of acylcarnitines by carnitine palmitoylotransferase 1 (CPT1) and further transport of acyl carnitine esters to mitochondrial matrix. Carnitine 52-63 carnitine palmitoyltransferase 1A Homo sapiens 138-142 32654140-7 2021 Inhibition of carnitine transport by chemotherapeutics, such as vinorelbine and vincristine, led to inhibition of FAO, which was further intensified by etomoxir - a CPT1 inhibitor. Carnitine 14-23 carnitine palmitoyltransferase 1A Homo sapiens 165-169 32641979-8 2020 CPT 1A, CPT 2, and CRAT, which are extensively involved in carnitine system-mediated fatty acid beta-oxidation pathway were also found to be abnormally expressed in breast cancer. Carnitine 59-68 carnitine palmitoyltransferase 1A Homo sapiens 0-6 33658919-6 2020 Subsequently, metabolomic results of cells and serum analyses demonstrated an aberrant level of carnitine palmitoyltransferase I (CPT1A). Carnitine 96-105 carnitine palmitoyltransferase 1A Homo sapiens 130-135 32733282-8 2020 The first component of this system is the carnitine palmitoyltransferase 1 (CPT1) responsible for transfer acyl moieties to carnitine. Carnitine 42-51 carnitine palmitoyltransferase 1A Homo sapiens 76-80 28076827-4 2017 Finally, we investigated the effects of (R)-1, (S)-1 and (R,S)-2 on mitochondrial function and demonstrated that they activate the carnitine shuttle system through upregulation of carnitine/acylcarnitine carrier (CAC) and carnitine-palmitoyl-transferase 1 (CPT1) genes. Carnitine 131-140 carnitine palmitoyltransferase 1A Homo sapiens 222-255 28076827-4 2017 Finally, we investigated the effects of (R)-1, (S)-1 and (R,S)-2 on mitochondrial function and demonstrated that they activate the carnitine shuttle system through upregulation of carnitine/acylcarnitine carrier (CAC) and carnitine-palmitoyl-transferase 1 (CPT1) genes. Carnitine 131-140 carnitine palmitoyltransferase 1A Homo sapiens 257-261 28076827-4 2017 Finally, we investigated the effects of (R)-1, (S)-1 and (R,S)-2 on mitochondrial function and demonstrated that they activate the carnitine shuttle system through upregulation of carnitine/acylcarnitine carrier (CAC) and carnitine-palmitoyl-transferase 1 (CPT1) genes. Carnitine 180-189 carnitine palmitoyltransferase 1A Homo sapiens 222-255 28076827-4 2017 Finally, we investigated the effects of (R)-1, (S)-1 and (R,S)-2 on mitochondrial function and demonstrated that they activate the carnitine shuttle system through upregulation of carnitine/acylcarnitine carrier (CAC) and carnitine-palmitoyl-transferase 1 (CPT1) genes. Carnitine 180-189 carnitine palmitoyltransferase 1A Homo sapiens 257-261 26716645-4 2016 Carnitine palmitoyltransferase 1 (CPT1) is a rate-limiting enzyme of fatty acid beta-oxidation (FAO) that catalyzes the transfer of long-chain acyl group of the acyl-CoA ester to carnitine, thereby shuttling fatty acids into the mitochondrial matrix for beta-oxidation. Carnitine 179-188 carnitine palmitoyltransferase 1A Homo sapiens 0-32 26716645-4 2016 Carnitine palmitoyltransferase 1 (CPT1) is a rate-limiting enzyme of fatty acid beta-oxidation (FAO) that catalyzes the transfer of long-chain acyl group of the acyl-CoA ester to carnitine, thereby shuttling fatty acids into the mitochondrial matrix for beta-oxidation. Carnitine 179-188 carnitine palmitoyltransferase 1A Homo sapiens 34-38 17452323-1 2007 Carnitine palmitoyltransferase 1 (CPT1) catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine in the presence of l-carnitine, thus facilitating the entry of fatty acids to mitochondria, in a process that is physiologically inhibited by malonyl-CoA. Carnitine 123-134 carnitine palmitoyltransferase 1A Homo sapiens 0-32 23818692-8 2013 In conclusion, increasing muscle total carnitine in healthy humans can modulate muscle metabolism, energy expenditure and body composition over a prolonged period, which is entirely consistent with a carnitine-mediated increase in muscle long-chain acyl-group translocation via CPT1. Carnitine 200-209 carnitine palmitoyltransferase 1A Homo sapiens 278-282 22435679-13 2012 The decreased expressions of PPAR-alpha, carnitine palmitoyl transferase 1 (CPT1) and acyl-CoA oxidase (ACOX) induced by H2O2 can be attenuated by L-carnitine. Carnitine 147-158 carnitine palmitoyltransferase 1A Homo sapiens 41-74 22435679-13 2012 The decreased expressions of PPAR-alpha, carnitine palmitoyl transferase 1 (CPT1) and acyl-CoA oxidase (ACOX) induced by H2O2 can be attenuated by L-carnitine. Carnitine 147-158 carnitine palmitoyltransferase 1A Homo sapiens 76-80 23430868-2 2012 CPT1 deficiency is included in newborn screening programs in a number of countries to allow presymptomatic detection and early treatment of affected patients.We present a case of presymptomatic CPT1A deficiency detected through newborn screening in Denmark with diagnostic levels of carnitine and acylcarnitines in the initial dried blood spot. Carnitine 283-292 carnitine palmitoyltransferase 1A Homo sapiens 194-199 26708865-3 2016 Although CPT1C exhibits high sequence similarity to CPT1A and CPT1B, it is specifically expressed in neurons (a cell-type that does not use fatty acids as fuel to any major extent), it is localized in the endoplasmic reticulum of cells, and it has minimal CPT1 catalytic activity with l-carnitine and acyl-CoA esters. Carnitine 285-296 carnitine palmitoyltransferase 1A Homo sapiens 9-13 26261054-7 2015 In terms of nutrient regulation, carnitine metabolism regulates hypothalamic fatty acid sensing through the actions of CPT1 and has an underappreciated role in glucose sensing since carnitine metabolism also buffers mitochondrial matrix levels of acetyl-CoA, an allosteric inhibitor of pyruvate dehydrogenase and hence glucose metabolism. Carnitine 33-42 carnitine palmitoyltransferase 1A Homo sapiens 119-123 17452323-1 2007 Carnitine palmitoyltransferase 1 (CPT1) catalyzes the conversion of palmitoyl-CoA to palmitoylcarnitine in the presence of l-carnitine, thus facilitating the entry of fatty acids to mitochondria, in a process that is physiologically inhibited by malonyl-CoA. Carnitine 123-134 carnitine palmitoyltransferase 1A Homo sapiens 34-38 16283381-7 2006 Carnitine treated patients showed a rise in plasma carnitine which led to an increase of relative mRNA levels from CPT1A (liver isoform of carnitine palmitoyltransferase) and OCTN2 (carnitine transporter). Carnitine 0-9 carnitine palmitoyltransferase 1A Homo sapiens 115-120 16362726-0 2006 Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Carnitine 108-119 carnitine palmitoyltransferase 1A Homo sapiens 67-72 16362726-3 2006 AIM OF STUDY: To investigate the effect of co-treatment of genistein and L-carnitine on CPT1A enzyme activity and to determine whether daidzein also increases CPT1A activity and to establish a cell line that can be used to screen chemicals to regulate CPT1A transcription. Carnitine 73-84 carnitine palmitoyltransferase 1A Homo sapiens 88-93 16362726-4 2006 METHODS: The enzyme activities of CPT1A were determined after HepG2 cells were incubated with 10 microM genistein or 10 microM daidzein or 1 mM L-carnitine or in combination with 10 microM genistein and 1 mM L-carnitine or in combination with 10 microM daidzein and 1 mM L-carnitine. Carnitine 144-155 carnitine palmitoyltransferase 1A Homo sapiens 34-39 16362726-4 2006 METHODS: The enzyme activities of CPT1A were determined after HepG2 cells were incubated with 10 microM genistein or 10 microM daidzein or 1 mM L-carnitine or in combination with 10 microM genistein and 1 mM L-carnitine or in combination with 10 microM daidzein and 1 mM L-carnitine. Carnitine 208-219 carnitine palmitoyltransferase 1A Homo sapiens 34-39 16362726-4 2006 METHODS: The enzyme activities of CPT1A were determined after HepG2 cells were incubated with 10 microM genistein or 10 microM daidzein or 1 mM L-carnitine or in combination with 10 microM genistein and 1 mM L-carnitine or in combination with 10 microM daidzein and 1 mM L-carnitine. Carnitine 208-219 carnitine palmitoyltransferase 1A Homo sapiens 34-39 16362726-7 2006 RESULTS: The enzyme activity of CPT1A was at least 2.3- fold higher in L-carnitine and genistein co-treated HepG2 cells than either single-agent treated cells. Carnitine 71-82 carnitine palmitoyltransferase 1A Homo sapiens 32-37 16362726-11 2006 Co-treatment of L-carnitine and genistein additively increases CPT1A enzyme activity in HepG2 cells. Carnitine 16-27 carnitine palmitoyltransferase 1A Homo sapiens 63-68 16283381-7 2006 Carnitine treated patients showed a rise in plasma carnitine which led to an increase of relative mRNA levels from CPT1A (liver isoform of carnitine palmitoyltransferase) and OCTN2 (carnitine transporter). Carnitine 51-60 carnitine palmitoyltransferase 1A Homo sapiens 115-120 9546635-5 1998 Addition of L-carnitine to the incubation medium, which stimulates carnitine palmitoyl-transferase I (CPTI) accelerated palmitate oxidation 3 fold in NB and approximately 2 fold in HY and 2 week cells. Carnitine 12-23 carnitine palmitoyltransferase 1A Homo sapiens 67-100 11052958-4 2000 The CPT-1-independent event of palmitoyl carnitine oxidation was also depressed (P < 0.01) by approximately 45%. Carnitine 41-50 carnitine palmitoyltransferase 1A Homo sapiens 4-9 9546635-5 1998 Addition of L-carnitine to the incubation medium, which stimulates carnitine palmitoyl-transferase I (CPTI) accelerated palmitate oxidation 3 fold in NB and approximately 2 fold in HY and 2 week cells. Carnitine 12-23 carnitine palmitoyltransferase 1A Homo sapiens 102-106 31555131-9 2019 L-Carnitine treatment augmented FAO but attenuated CSE-induced apoptosis by upregulating Cpt1a. Carnitine 0-11 carnitine palmitoyltransferase 1A Homo sapiens 89-94 34245263-4 2021 RESULTS: IUGR fetuses exhibited an upregulation of key genes associated with fatty acid breakdown and beta-oxidation (Acadvl, Acadl, Acaa2), and mitochondrial carnitine shuttle (Cpt1a, Cpt2), instigating a metabolic gene reprogramming in the heart. Carnitine 159-168 carnitine palmitoyltransferase 1A Homo sapiens 178-183 34765928-6 2021 Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Carnitine 44-53 carnitine palmitoyltransferase 1A Homo sapiens 79-84 34233743-5 2021 Increased free carnitine levels and a significantly increased C0/(C16 + C18) ratio were detected by tandem mass spectrometry, and subsequently, mutations in CPT1A were found by gene sequence analysis. Carnitine 15-24 carnitine palmitoyltransferase 1A Homo sapiens 157-162 34233743-12 2021 CONCLUSION: This is the first case of CPT1A deficiency detected through newborn screening based on diagnostic levels of free carnitine, in China. Carnitine 125-134 carnitine palmitoyltransferase 1A Homo sapiens 38-43 34167568-0 2021 Exogenous L-carnitine ameliorates burn-induced cellular and mitochondrial injury of hepatocytes by restoring CPT1 activity. Carnitine 10-21 carnitine palmitoyltransferase 1A Homo sapiens 109-113 34167568-10 2021 Carnitine administration recovered CPT1 activity and improved all indicators related to cellular and fatty acid metabolism and mitochondrial injury. Carnitine 0-9 carnitine palmitoyltransferase 1A Homo sapiens 35-39 34167568-11 2021 Inhibition of CPT1 activity with etomoxir induced hepatocyte injuries similar to those in burn patients and burned rats; carnitine supplementation restored CPT1 activity and ameliorated these injuries. Carnitine 121-130 carnitine palmitoyltransferase 1A Homo sapiens 156-160 34167568-13 2021 CONCLUSION: Exogenous carnitine exerts protective effects against severe burn-induced cellular, fatty-acid metabolism, and mitochondrial dysfunction of hepatocytes by restoring CPT1 activity. Carnitine 22-31 carnitine palmitoyltransferase 1A Homo sapiens 177-181