PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34899326-4 2021 In this study, we established a mouse model of obesity-related AF through high-fat diet (HFD) feeding, and used l-carnitine (LCA, 150 mg/kg BW/d), an endogenous cofactor of carnitine palmitoyl-transferase-1B (CPT1B; the rate-limiting enzyme of FAO) to investigate whether FAO promotion can attenuate the AF susceptibility in obesity. Carnitine 112-123 carnitine palmitoyltransferase 1b, muscle Mus musculus 173-207 34899326-4 2021 In this study, we established a mouse model of obesity-related AF through high-fat diet (HFD) feeding, and used l-carnitine (LCA, 150 mg/kg BW/d), an endogenous cofactor of carnitine palmitoyl-transferase-1B (CPT1B; the rate-limiting enzyme of FAO) to investigate whether FAO promotion can attenuate the AF susceptibility in obesity. Carnitine 112-123 carnitine palmitoyltransferase 1b, muscle Mus musculus 209-214 34899326-4 2021 In this study, we established a mouse model of obesity-related AF through high-fat diet (HFD) feeding, and used l-carnitine (LCA, 150 mg/kg BW/d), an endogenous cofactor of carnitine palmitoyl-transferase-1B (CPT1B; the rate-limiting enzyme of FAO) to investigate whether FAO promotion can attenuate the AF susceptibility in obesity. Carnitine 125-128 carnitine palmitoyltransferase 1b, muscle Mus musculus 173-207 35409465-10 2022 The reduced lipid accumulation was associated with low expression of fatty acid synthase (Cpt1; p <= 0.05) and an upregulation of the fatty acid oxidation gene, carnitine palmitoyltransferase (Cpt1; p <= 0.01), as compared with the obese control mice. Carnitine 161-170 carnitine palmitoyltransferase 1b, muscle Mus musculus 193-197 31735087-0 2020 Transcribed Ultraconserved Regions, Uc.323, Ameliorates Cardiac Hypertrophy by Regulating the Transcription of CPT1b (Carnitine Palmitoyl transferase 1b). Carnitine 118-137 carnitine palmitoyltransferase 1b, muscle Mus musculus 111-116 31811407-5 2020 Carnitine palmitoyltransferase 1b (CPT1b), a rate-limiting enzyme of mitochondrial beta-oxidation in adult heart, was sharply decreased in LRP6 deficiency hearts, coincident with the activation of Drp1. Carnitine 0-9 carnitine palmitoyltransferase 1b, muscle Mus musculus 35-40 31735087-7 2020 We further mapped the possible target genes of uc.323 through global microarray mRNA expression analysis after uc.323 knockdown and found that uc.323 regulated the expression of cardiac hypertrophy-related genes such as CPT1b (Carnitine Palmitoyl transferase 1b). Carnitine 227-246 carnitine palmitoyltransferase 1b, muscle Mus musculus 220-225 30635360-0 2019 High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to l-carnitine. Carnitine 81-92 carnitine palmitoyltransferase 1b, muscle Mus musculus 33-65 31735033-10 2019 On the other hand, CPT1 (Carnitine palmitoyltransferase) was found to be significantly activated at lower concentrations of oxyresveratrol up to 1.89 +- 0.04 fold as compared to HFD, and it could be a leading reason for UCP1 activation. Carnitine 25-34 carnitine palmitoyltransferase 1b, muscle Mus musculus 19-23 30635360-5 2019 In contrast, CPT-I sensitivity to l-carnitine was only altered following HI, as HI exercise attenuated l-carnitine sensitivity by ~40%. Carnitine 34-45 carnitine palmitoyltransferase 1b, muscle Mus musculus 13-18 30635360-5 2019 In contrast, CPT-I sensitivity to l-carnitine was only altered following HI, as HI exercise attenuated l-carnitine sensitivity by ~40%. Carnitine 103-114 carnitine palmitoyltransferase 1b, muscle Mus musculus 13-18 30635360-6 2019 Moreover, modeling the in vivo concentrations of l-carnitine and P-CoA during exercise suggests that CPT-I flux is ~25% lower following HI, attributed equally to reductions in l-carnitine content and l-carnitine sensitivity. Carnitine 49-60 carnitine palmitoyltransferase 1b, muscle Mus musculus 101-106 30635360-6 2019 Moreover, modeling the in vivo concentrations of l-carnitine and P-CoA during exercise suggests that CPT-I flux is ~25% lower following HI, attributed equally to reductions in l-carnitine content and l-carnitine sensitivity. Carnitine 176-187 carnitine palmitoyltransferase 1b, muscle Mus musculus 101-106 30635360-6 2019 Moreover, modeling the in vivo concentrations of l-carnitine and P-CoA during exercise suggests that CPT-I flux is ~25% lower following HI, attributed equally to reductions in l-carnitine content and l-carnitine sensitivity. Carnitine 176-187 carnitine palmitoyltransferase 1b, muscle Mus musculus 101-106 30635360-7 2019 Altogether, these data further implicate CPT-I flux as a key event influencing metabolic interactions during exercise, as a decline in l-carnitine sensitivity in addition to availability at higher power outputs could impair mitochondrial fatty acid oxidation. Carnitine 135-146 carnitine palmitoyltransferase 1b, muscle Mus musculus 41-46 23098614-2 2012 CPT1 isoenzymes transfer long chain acyl groups to carnitine. Carnitine 51-60 carnitine palmitoyltransferase 1b, muscle Mus musculus 0-4 27021847-11 2016 l-carnitine administration improved intestinal microbiome and biliary acid balance, upregulated the hepatic mitochondrial membrane uptake related gene Cpt1 in non-cancerous tissue, and did not alter stem-like cell numbers. Carnitine 0-11 carnitine palmitoyltransferase 1b, muscle Mus musculus 151-155 26647854-4 2016 The aim of the present study was to examine the role of the CPT I-dependent peroxisome proliferator-activated receptor (PPAR)gamma signaling pathway in the ameliorative effect of L-carnitine on the liver inflammatory response. Carnitine 179-190 carnitine palmitoyltransferase 1b, muscle Mus musculus 60-65 26647854-8 2016 These changes induced by L-carnitine were reversed by treatment with etomoxir, an inhibitor of CPT I. Carnitine 25-36 carnitine palmitoyltransferase 1b, muscle Mus musculus 95-100 26647854-12 2016 Taken together, these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARgamma signaling, including the downstream molecules of NF-kappaB p65 and Cox-2. Carnitine 48-59 carnitine palmitoyltransferase 1b, muscle Mus musculus 164-169 26452216-11 2015 These ameliorative effects of L-carnitine were lessened by the carnitine palmitoyltransferase I (CPT I) inhibitor, etomoxir. Carnitine 30-41 carnitine palmitoyltransferase 1b, muscle Mus musculus 63-95 26452216-11 2015 These ameliorative effects of L-carnitine were lessened by the carnitine palmitoyltransferase I (CPT I) inhibitor, etomoxir. Carnitine 30-41 carnitine palmitoyltransferase 1b, muscle Mus musculus 97-102 21532335-4 2011 In the present study, we aim to assess the effects of L-carnitine on the activity and expression of CPT I and II in the liver of cachectic cancer mice. Carnitine 54-65 carnitine palmitoyltransferase 1b, muscle Mus musculus 100-105 22778252-5 2012 The addition of l-carnitine enabled the metabolic channeling of acyl-CoA through carnitine palmitoyltransferases (CPT-1/2) and attenuated the palmitoyl-CoA-mediated amplification of calcium-induced mPTP opening. Carnitine 16-27 carnitine palmitoyltransferase 1b, muscle Mus musculus 114-121 21532335-8 2011 These effects of L-carnitine on cancer cachexia mice were accompanied by the upregulation of mRNA level of CPT I and II and increased enzyme activity of CPT I in the liver, as well as the downregulation of serum TNF-alpha and IL-6 levels. Carnitine 17-28 carnitine palmitoyltransferase 1b, muscle Mus musculus 107-119 21532335-8 2011 These effects of L-carnitine on cancer cachexia mice were accompanied by the upregulation of mRNA level of CPT I and II and increased enzyme activity of CPT I in the liver, as well as the downregulation of serum TNF-alpha and IL-6 levels. Carnitine 17-28 carnitine palmitoyltransferase 1b, muscle Mus musculus 107-112 20686180-3 2010 Generation of ATP from lipids occurs within mitochondria via beta-oxidation of fatty acids, with the rate-limiting step catalyzed by carnitine palmitoyl transferase I (CPT1B), a process also requiring carnitine. Carnitine 133-142 carnitine palmitoyltransferase 1b, muscle Mus musculus 168-173 17201630-6 2006 Especially in liver, the results showed that genistein with carnitine transcriptionally up-regulated expressions of acyl-coenzyme A synthetase (ACS) and carnitine palmitoyltransferase-I (CPT-I) by approximately 50% and 40%, respectively, compared with genistein alone. Carnitine 60-69 carnitine palmitoyltransferase 1b, muscle Mus musculus 153-185 17201630-6 2006 Especially in liver, the results showed that genistein with carnitine transcriptionally up-regulated expressions of acyl-coenzyme A synthetase (ACS) and carnitine palmitoyltransferase-I (CPT-I) by approximately 50% and 40%, respectively, compared with genistein alone. Carnitine 60-69 carnitine palmitoyltransferase 1b, muscle Mus musculus 187-192 17201630-8 2006 On the other hand, the effects of genistein and genistein with carnitine on the expressions of ACS and CPT-I in muscle were not significant. Carnitine 63-72 carnitine palmitoyltransferase 1b, muscle Mus musculus 103-108 8830050-0 1996 Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice. Carnitine 92-103 carnitine palmitoyltransferase 1b, muscle Mus musculus 24-56 8830050-6 1996 When the JVS mice were treated with carnitine, CPT I gene expression was repressed to the level of normal mice. Carnitine 36-45 carnitine palmitoyltransferase 1b, muscle Mus musculus 47-52 16651524-5 2006 All three CPTs bind malonyl-CoA, and CPT1a and CPT1b catalyze acyl transfer from various fatty acyl-CoAs to carnitine, whereas CPT1c does not. Carnitine 108-117 carnitine palmitoyltransferase 1b, muscle Mus musculus 47-52