PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26694920-7 2015 Enhanced PPARbeta/delta and PPARalpha expression and DNA binding induces expression of FA oxidation enzymes, increasing muscle carnitine and lowering tissue malonyl-CoA concentrations, thereby supporting intra-mitochondrial pathways of FA oxidation and enhancing mitochondrial respiration. Carnitine 127-136 peroxisome proliferator activated receptor alpha Mus musculus 28-37 26647854-4 2016 The aim of the present study was to examine the role of the CPT I-dependent peroxisome proliferator-activated receptor (PPAR)gamma signaling pathway in the ameliorative effect of L-carnitine on the liver inflammatory response. Carnitine 179-190 peroxisome proliferator activated receptor alpha Mus musculus 120-124 26647854-7 2016 The results showed that oral administration of L-carnitine in these mice improved hepatocyte necrosis, liver cell cord derangement and hydropic or fatty degeneration of the liver cells in the liver tissues, decreased serum levels of malondialdehyde, increased serum levels of superoxide dismutase and glutathione peroxidase, and elevated the expression levels of PPARalpha and PPARgamma at the mRNA and protein levels. Carnitine 47-58 peroxisome proliferator activated receptor alpha Mus musculus 363-372 26452216-12 2015 The mRNA and protein expression levels of PPAR-alpha and PPAR-gamma were decreased in the livers of cancer cachectic mice and increased after L-carnitine administration, which attenuated the increased mRNA expression levels of sterol-regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Carnitine 142-153 peroxisome proliferator activated receptor alpha Mus musculus 42-52 24962334-8 2014 Electrophoretic mobility shift and supershift assays proved the sequence element (-228/-222) to be an L-carnitine sensitive RXRalpha binding site, which also showed sensitivity to application of anti-PPARalpha and anti-PPARbp antibodies. Carnitine 102-113 peroxisome proliferator activated receptor alpha Mus musculus 200-209 25090113-0 2014 L-carnitine protects against carboplatin-mediated renal injury: AMPK- and PPARalpha-dependent inactivation of NFAT3. Carnitine 0-11 peroxisome proliferator activated receptor alpha Mus musculus 74-83 25090113-7 2014 These carboplatin-mediated effects were prevented by L-carnitine through a mechanism dependent on AMPK phosphorylation and subsequent PPARalpha activation. Carnitine 53-64 peroxisome proliferator activated receptor alpha Mus musculus 134-143 25090113-9 2014 The coimmunoprecipitation of the nuclear factor (NF) kappaB proteins increased following the induction of PPARalpha by L-carnitine, which reduced NFkappaB transactivational activity and cytokine expression. Carnitine 119-130 peroxisome proliferator activated receptor alpha Mus musculus 106-115 25090113-10 2014 The in vivo study showed that the inactivation of AMPK suppressed the protective effect of L-carnitine in carboplatin-treated mice, indicating that AMPK phosphorylation is required for PPARalpha activation in the L-carnitine-mediated protection of RTC apoptosis caused by carboplatin. Carnitine 91-102 peroxisome proliferator activated receptor alpha Mus musculus 185-194 25090113-10 2014 The in vivo study showed that the inactivation of AMPK suppressed the protective effect of L-carnitine in carboplatin-treated mice, indicating that AMPK phosphorylation is required for PPARalpha activation in the L-carnitine-mediated protection of RTC apoptosis caused by carboplatin. Carnitine 213-224 peroxisome proliferator activated receptor alpha Mus musculus 185-194 25090113-11 2014 The results of our study provide molecular evidence that L-carnitine prevents carboplatin-mediated apoptosis through AMPK-mediated PPARalpha activation. Carnitine 57-68 peroxisome proliferator activated receptor alpha Mus musculus 131-140 22285688-9 2012 Together with the recent identification of the mouse BBD and the mouse OCTN2 genes as PPARalpha target genes this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake. Carnitine 238-247 peroxisome proliferator activated receptor alpha Mus musculus 135-144 22285688-0 2012 The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor alpha. Carnitine 28-37 peroxisome proliferator activated receptor alpha Mus musculus 120-168 22285688-1 2012 Genes involved in carnitine uptake and synthesis, such as organic cation transporter-2 (OCTN2) and gamma-butyrobetaine dioxygenase (BBD), have been shown to be regulated by peroxisome proliferator-activated receptor (PPAR)alpha directly. Carnitine 18-27 peroxisome proliferator activated receptor alpha Mus musculus 217-221 22285688-9 2012 Together with the recent identification of the mouse BBD and the mouse OCTN2 genes as PPARalpha target genes this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake. Carnitine 183-192 peroxisome proliferator activated receptor alpha Mus musculus 86-95 22285688-9 2012 Together with the recent identification of the mouse BBD and the mouse OCTN2 genes as PPARalpha target genes this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake. Carnitine 183-192 peroxisome proliferator activated receptor alpha Mus musculus 135-144 22285688-9 2012 Together with the recent identification of the mouse BBD and the mouse OCTN2 genes as PPARalpha target genes this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake. Carnitine 238-247 peroxisome proliferator activated receptor alpha Mus musculus 86-95 22285688-9 2012 Together with the recent identification of the mouse BBD and the mouse OCTN2 genes as PPARalpha target genes this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake. Carnitine 238-247 peroxisome proliferator activated receptor alpha Mus musculus 86-95 22285688-9 2012 Together with the recent identification of the mouse BBD and the mouse OCTN2 genes as PPARalpha target genes this finding confirm that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in carnitine synthesis and carnitine uptake. Carnitine 238-247 peroxisome proliferator activated receptor alpha Mus musculus 135-144 23130577-11 2012 The results contrast with those in humans and mice that show a significant effect of synthetic PPARalpha agonists on carnitine homeostasis in humans and mice. Carnitine 117-126 peroxisome proliferator activated receptor alpha Mus musculus 95-104 19491382-0 2009 Peroxisome proliferator-activated receptor alpha plays a crucial role in L-carnitine anti-apoptosis effect in renal tubular cells. Carnitine 73-84 peroxisome proliferator activated receptor alpha Mus musculus 0-48 20858838-11 2010 We postulate that this phenomenon is triggered by deactivation of peroxisome proliferator activated receptor alpha and leads to deregulation of carnitine-shuttle genes. Carnitine 144-153 peroxisome proliferator activated receptor alpha Mus musculus 66-114 21549104-1 2011 Convincing evidence from studies with peroxisome proliferator-activated receptor (PPAR)alpha-deficient mice suggested that the carnitine biosynthetic enzyme gamma-butyrobetaine dioxygenase (BBD) is regulated by PPARalpha. Carnitine 127-136 peroxisome proliferator activated receptor alpha Mus musculus 82-92 21549104-1 2011 Convincing evidence from studies with peroxisome proliferator-activated receptor (PPAR)alpha-deficient mice suggested that the carnitine biosynthetic enzyme gamma-butyrobetaine dioxygenase (BBD) is regulated by PPARalpha. Carnitine 127-136 peroxisome proliferator activated receptor alpha Mus musculus 211-220 21549104-7 2011 The results confirm emerging evidence from recent studies that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in both, carnitine synthesis and carnitine uptake. Carnitine 111-120 peroxisome proliferator activated receptor alpha Mus musculus 63-72 21549104-7 2011 The results confirm emerging evidence from recent studies that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in both, carnitine synthesis and carnitine uptake. Carnitine 172-181 peroxisome proliferator activated receptor alpha Mus musculus 63-72 21549104-7 2011 The results confirm emerging evidence from recent studies that PPARalpha plays a key role in the regulation of carnitine homeostasis by controlling genes involved in both, carnitine synthesis and carnitine uptake. Carnitine 172-181 peroxisome proliferator activated receptor alpha Mus musculus 63-72 19491382-11 2009 We found that the activity of the potential PGI(2) nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARalpha), was elevated by L-carnitine treatment. Carnitine 147-158 peroxisome proliferator activated receptor alpha Mus musculus 69-117 19491382-11 2009 We found that the activity of the potential PGI(2) nuclear receptor, peroxisome proliferator-activated receptor alpha (PPARalpha), was elevated by L-carnitine treatment. Carnitine 147-158 peroxisome proliferator activated receptor alpha Mus musculus 119-128 19491382-12 2009 The siRNA-mediated blockage of PPARalpha considerably reduced the anti-apoptotic effect of L-carnitine. Carnitine 91-102 peroxisome proliferator activated receptor alpha Mus musculus 31-40 19491382-13 2009 In PPARalpha-deficient mice, L-carnitine treatment also lost the inhibitory effect on gentamicin-induced apoptosis in kidneys. Carnitine 29-40 peroxisome proliferator activated receptor alpha Mus musculus 3-12 19491382-14 2009 CONCLUSIONS: Based on these findings, we suggest that L-carnitine protects renal tubular cells from gentamicin-induced apoptosis through PGI(2)-mediated PPARalpha activation. Carnitine 54-65 peroxisome proliferator activated receptor alpha Mus musculus 153-162 17692817-0 2007 PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Carnitine 42-51 peroxisome proliferator activated receptor alpha Mus musculus 0-10 18296741-8 2008 In conclusion, this study shows that transcriptional upregulation of OCTN2 and OCTN3 in tissues and of enzymes involved in hepatic carnitine biosynthesis are mediated by PPAR alpha. Carnitine 131-140 peroxisome proliferator activated receptor alpha Mus musculus 170-180 18296741-9 2008 It also shows that PPAR alpha mediates changes of whole-body carnitine homeostasis in mice by upregulation of carnitine transporters and enzymes involved in carnitine synthesis. Carnitine 61-70 peroxisome proliferator activated receptor alpha Mus musculus 19-29 18296741-9 2008 It also shows that PPAR alpha mediates changes of whole-body carnitine homeostasis in mice by upregulation of carnitine transporters and enzymes involved in carnitine synthesis. Carnitine 110-119 peroxisome proliferator activated receptor alpha Mus musculus 19-29 18945875-0 2009 Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. Carnitine 60-69 peroxisome proliferator activated receptor alpha Mus musculus 23-32 18945875-0 2009 Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. Carnitine 133-142 peroxisome proliferator activated receptor alpha Mus musculus 23-32 18945875-6 2009 PPARalpha(-/-) mice had 40-50% lower plasma and tissue levels of free carnitine, corresponding with diminished hepatic expression of genes involved in carnitine biosynthesis and transport. Carnitine 70-79 peroxisome proliferator activated receptor alpha Mus musculus 0-9 18945875-6 2009 PPARalpha(-/-) mice had 40-50% lower plasma and tissue levels of free carnitine, corresponding with diminished hepatic expression of genes involved in carnitine biosynthesis and transport. Carnitine 151-160 peroxisome proliferator activated receptor alpha Mus musculus 0-9 18945875-7 2009 One week of oral carnitine supplementation conferred partial metabolic recovery in the PPARalpha(-/-) mice. Carnitine 17-26 peroxisome proliferator activated receptor alpha Mus musculus 87-96 18296741-0 2008 PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Carnitine 127-136 peroxisome proliferator activated receptor alpha Mus musculus 0-10 17692817-0 2007 PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Carnitine 92-101 peroxisome proliferator activated receptor alpha Mus musculus 0-10 17692817-1 2007 In fasted rodents hepatic carnitine concentration increases considerably which is not observed in PPAR alpha-/- mice, indicating that PPAR alpha is involved in carnitine homeostasis. Carnitine 26-35 peroxisome proliferator activated receptor alpha Mus musculus 134-144 17692817-2 2007 To investigate the mechanisms underlying the PPAR alpha-dependent hepatic carnitine accumulation we measured carnitine biosynthesis enzyme activities, levels of carnitine biosynthesis intermediates, acyl-carnitines and OCTN2 mRNA levels in tissues of untreated, fasted or Wy-14643-treated wild type and PPAR alpha-/- mice. Carnitine 74-83 peroxisome proliferator activated receptor alpha Mus musculus 45-55 17692817-3 2007 Here we show that both enhancement of carnitine biosynthesis (due to increased gamma-butyrobetaine dioxygenase activity), extra-hepatic gamma-butyrobetaine synthesis and increased hepatic carnitine import (OCTN2 expression) contributes to the increased hepatic carnitine levels after fasting and that these processes are PPAR alpha-dependent. Carnitine 188-197 peroxisome proliferator activated receptor alpha Mus musculus 321-331 17692817-3 2007 Here we show that both enhancement of carnitine biosynthesis (due to increased gamma-butyrobetaine dioxygenase activity), extra-hepatic gamma-butyrobetaine synthesis and increased hepatic carnitine import (OCTN2 expression) contributes to the increased hepatic carnitine levels after fasting and that these processes are PPAR alpha-dependent. Carnitine 188-197 peroxisome proliferator activated receptor alpha Mus musculus 321-331 15654129-7 2005 Investigation of carnitine biosynthesis revealed that PPARalpha is likely involved in the regulation of carnitine homeostasis. Carnitine 17-26 peroxisome proliferator activated receptor alpha Mus musculus 54-63 15654129-7 2005 Investigation of carnitine biosynthesis revealed that PPARalpha is likely involved in the regulation of carnitine homeostasis. Carnitine 104-113 peroxisome proliferator activated receptor alpha Mus musculus 54-63