PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31832001-11 2019 In addition, LB100 significantly downregulated the protein levels of acetyl-CoA carboxylase, sterol regulatory element-binding protein 1 and its lipogenesis target genes, including stearoyl-CoA desaturase-1 and fatty acid synthase, and upregulated the levels of proteins involved in fatty acid beta-oxidation, such as peroxisome proliferator-activated receptor alpha (PPARalpha), peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha), carnitine palmitoyltransferase 1alpha, acyl-CoA oxidase 1 and uncoupling protein 2, as well as the upstream mediators Sirt1 and AMPKalpha in the livers of HFD-fed mice. Carnitine 462-471 sterol regulatory element binding transcription factor 1 Mus musculus 93-136 28730830-6 2017 More importantly, quantitative real-time polymerase chain reaction (qRT-PCR) analysis indicated that L-Carnitine supplementation would effectively counteract the negative alterations in gene expression which related to lipid metabolism (Srebp1, Acaca, Fasn, and Scd1), metabolic regulator (mTOR) and circadian rhythm (Bmal1, Per1, Cry1 and Dec1) in the liver of mice subjected to the chronic jet-lag. Carnitine 101-112 sterol regulatory element binding transcription factor 1 Mus musculus 237-243 26452216-12 2015 The mRNA and protein expression levels of PPAR-alpha and PPAR-gamma were decreased in the livers of cancer cachectic mice and increased after L-carnitine administration, which attenuated the increased mRNA expression levels of sterol-regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Carnitine 142-153 sterol regulatory element binding transcription factor 1 Mus musculus 227-271 26452216-12 2015 The mRNA and protein expression levels of PPAR-alpha and PPAR-gamma were decreased in the livers of cancer cachectic mice and increased after L-carnitine administration, which attenuated the increased mRNA expression levels of sterol-regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Carnitine 142-153 sterol regulatory element binding transcription factor 1 Mus musculus 273-281