PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34169163-8	2021	Post-treatment with L-carnitine effectively increased the levels of GSH and AKT, elevated Nrf2 and its target genes and decreased the levels of MDA and TGFbeta1 in comparison with PD control rats.	Carnitine	20-31	AKT serine/threonine kinase 1	Rattus norvegicus	76-79	
34489184-8	2021	Treatment with L-carnitine + Co Q10 ameliorated cognitive impairment and oxidative stress, decreased the brain contents of inflammatory mediators; TNF-alpha, IL-6, and NF-kappabeta elevated AMPK and AKT, as compared to each drug.	Carnitine	15-26	AKT serine/threonine kinase 1	Rattus norvegicus	199-202	
34489184-10	2021	L-carnitine + Co Q10 play important role in AMPK/AKT/NF-kappabeta pathway that responsible for their antioxidant and anti-inflammatory effects against PD-induced brain injury in rats.	Carnitine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	49-52	
34489184-0	2021	L-carnitine and Co Q10 ameliorate potassium dichromate -induced acute brain injury in rats targeting AMPK/AKT/NF-kappabeta.	Carnitine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	106-109	
34489184-4	2021	The study aimed to investigate the influence of administration of L-carnitine or/and Co Q10 as theraputic agents against potassium dichromate (PD)-induced brain injury via AMPK/AKT/NF-kappabeta signaling pathway.	Carnitine	66-77	AKT serine/threonine kinase 1	Rattus norvegicus	177-180	
33152336-11	2021	We also found that all oligo-fucoidan, fucoxanthin, and L-carnitine inhibit H2O2-induced apoptosis and activated Akt in rat renal tubular cells.	Carnitine	56-67	AKT serine/threonine kinase 1	Rattus norvegicus	113-116	
32724594-9	2020	Inhibiting downstream targets (Akt or ERK signaling pathways) of IGF-1 signaling pathway partially blocked the effect the L-carnitine-induced increase in protein abundances of SNAT1 and SNAT2.	Carnitine	122-133	AKT serine/threonine kinase 1	Rattus norvegicus	31-34	
32555441-0	2021	L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling.	Carnitine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	107-110	
32555441-5	2021	Renoprotective effects of LC were assessed in terms of renal function, histopathology, oxidative stress, expression of inflammatory and fibrotic cytokines, programmed cell death (pyroptosis, apoptosis, and autophagy), mitochondrial function, and PI3K/AKT/PTEN signaling.	Carnitine	26-28	AKT serine/threonine kinase 1	Rattus norvegicus	251-254	
27841025-3	2016	Thus, we hypothesized that l-carnitine may have a protective effect on muscle atrophy induced by hindlimb suspension via the Akt1/mTOR and/or UPP.	Carnitine	27-38	AKT serine/threonine kinase 1	Rattus norvegicus	125-129	
25465043-8	2015	L-carnitine regulates the PTEN/Akt/mTOR signaling pathway, and enhances axonal plasticity while concurrently ameliorating oxidative stress and increasing oligodendrocyte myelination of axons, thereby improving WMLs and cognitive impairment in a rat chronic hypoperfusion model.	Carnitine	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	31-34	
23497226-0	2013	Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats.	Carnitine	19-28	AKT serine/threonine kinase 1	Rattus norvegicus	70-73	
23497226-3	2013	Based on the previous finding that carnitine increases plasma IGF-1 concentration, we investigated the hypothesis that carnitine down-regulates genes of the UPS by modulation of the of the IGF-1/PI3K/Akt signalling pathway which is an important regulator of UPS activity in muscle.	Carnitine	119-128	AKT serine/threonine kinase 1	Rattus norvegicus	200-203	
23497226-7	2013	Moreover, in skeletal muscle of rats fed the diet supplemented with carnitine there was an activation of the PI3K/Akt signalling pathway, as indicated by increased protein levels of phosphorylated (activated) Akt1 (P < 0.05).	Carnitine	68-77	AKT serine/threonine kinase 1	Rattus norvegicus	114-117	
23497226-7	2013	Moreover, in skeletal muscle of rats fed the diet supplemented with carnitine there was an activation of the PI3K/Akt signalling pathway, as indicated by increased protein levels of phosphorylated (activated) Akt1 (P < 0.05).	Carnitine	68-77	AKT serine/threonine kinase 1	Rattus norvegicus	209-213	
23497226-9	2013	The study moreover shows that supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway which in turn might contribute to the observed down-regulation of MuRF1 and muscle protein ubiquitination.	Carnitine	49-58	AKT serine/threonine kinase 1	Rattus norvegicus	100-103