PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28973641-0 2017 From the Cover: l-Carnitine via PPARgamma- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate. Carnitine 16-27 peroxisome proliferator activated receptor gamma Mus musculus 32-41 28973641-5 2017 l-carnitine reversed the EMT induction caused by PFOS and alleviated PFOS-mediated increases in cell migration by reactivating PPARgamma through the inhibition of Sirt1 activity. Carnitine 0-11 peroxisome proliferator activated receptor gamma Mus musculus 127-136 28973641-11 2017 Accordingly, l-carnitine alleviated EMT-associated renal fibrosis caused by PFOS through a Sirt1- and PPARgamma-dependent mechanism. Carnitine 13-24 peroxisome proliferator activated receptor gamma Mus musculus 102-111 28966077-9 2018 CONCLUSION: We conclude that the removal of dysfunctional mitochondria by induction of autophagy through PPARgamma may be a novel mechanism by which carnitine improves insulin resistance and mitochondrial dysfunction in obesity. Carnitine 149-158 peroxisome proliferator activated receptor gamma Mus musculus 105-114 32579962-9 2020 In conclusion, OCTN2 was downregulated in IBD by proinflammatory cytokines via the PPARgamma/RXRalpha pathways, which reduced l-Car concentration and subsequently induced IBD deterioration. Carnitine 126-131 peroxisome proliferator activated receptor gamma Mus musculus 83-92 26452216-0 2015 L-Carnitine Ameliorates Cancer Cachexia in Mice Partly via the Carnitine Palmitoyltransferase-Associated PPAR-gamma Signaling Pathway. Carnitine 0-11 peroxisome proliferator activated receptor gamma Mus musculus 105-115 26452216-2 2015 In the present study, we sought to investigate the role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) signaling pathway in the ameliorative effects of L-carnitine on cancer cachexia in a colon-26 tumor-bearing mouse model. Carnitine 174-185 peroxisome proliferator activated receptor gamma Mus musculus 63-111 26452216-2 2015 In the present study, we sought to investigate the role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) signaling pathway in the ameliorative effects of L-carnitine on cancer cachexia in a colon-26 tumor-bearing mouse model. Carnitine 174-185 peroxisome proliferator activated receptor gamma Mus musculus 113-123 26452216-12 2015 The mRNA and protein expression levels of PPAR-alpha and PPAR-gamma were decreased in the livers of cancer cachectic mice and increased after L-carnitine administration, which attenuated the increased mRNA expression levels of sterol-regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Carnitine 142-153 peroxisome proliferator activated receptor gamma Mus musculus 57-67 26452216-13 2015 Similar to pioglitazone, L-carnitine augmented the phosphorylation of PPAR-gamma and attenuated the expression levels of phospho-p65 and cyclooxygenase (COX)-2. Carnitine 25-36 peroxisome proliferator activated receptor gamma Mus musculus 70-80 26452216-15 2015 CONCLUSION: L-Carnitine exerts its ameliorative effects in cancer cachexia in association with the PPAR-gamma signaling pathway. Carnitine 12-23 peroxisome proliferator activated receptor gamma Mus musculus 99-109 27171144-7 2016 Furthermore, Sirt1 also deacetylated p53 and then increased the binding of p53 to Bax, resulting in increased cytosolic cytochrome C. The effect of PPARgamma inactivation by PFOS was validated using the PPARgamma antagonist GW9662, whereas the adverse effects of PFOS were prevented by PPARgamma overexpression and activators, rosiglitozone and L-carnitine, in RTCs. Carnitine 345-356 peroxisome proliferator activated receptor gamma Mus musculus 148-157 27171144-9 2016 Altogether, we provide in vivo and in vitro evidence for the protective mechanism of L-carnitine in eliminating PFOS-mediated renal injury, at least partially, through PPARgamma activation. Carnitine 85-96 peroxisome proliferator activated receptor gamma Mus musculus 168-177 26647854-0 2016 L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPARgamma signaling. Carnitine 0-11 peroxisome proliferator activated receptor gamma Mus musculus 113-122 26647854-7 2016 The results showed that oral administration of L-carnitine in these mice improved hepatocyte necrosis, liver cell cord derangement and hydropic or fatty degeneration of the liver cells in the liver tissues, decreased serum levels of malondialdehyde, increased serum levels of superoxide dismutase and glutathione peroxidase, and elevated the expression levels of PPARalpha and PPARgamma at the mRNA and protein levels. Carnitine 47-58 peroxisome proliferator activated receptor gamma Mus musculus 377-386 26647854-9 2016 The inhibitory effect of L-carnitine on the increased expression level of nuclear factor (NF)-kappaB p65 in the peripheral blood mononuclear cells was markedly weakened by GW9662, a selective inhibitor of PPAR-gamma. Carnitine 25-36 peroxisome proliferator activated receptor gamma Mus musculus 205-215 26647854-12 2016 Taken together, these results demonstrated that L-carnitine ameliorated liver inflammation and serum pro-inflammatory markers in cancer cachexia through regulating CPT I-dependent PPARgamma signaling, including the downstream molecules of NF-kappaB p65 and Cox-2. Carnitine 48-59 peroxisome proliferator activated receptor gamma Mus musculus 180-189