PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24227843-4 2014 Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases. Lysine 32-38 angiotensin converting enzyme 2 Homo sapiens 55-59 24227843-4 2014 Here, we show that arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for cleavage by TMPRSS2 and HAT and that ACE2 processing is required for augmentation of SARS-S-driven entry by these proteases. Lysine 32-38 angiotensin converting enzyme 2 Homo sapiens 138-142 34031383-4 2021 LSD1 colocalized with ACE2 at the cell surface to maintain demethylated SARS-CoV-2 spike receptor-binding domain lysine 31 to promote virus-ACE2 interactions. Lysine 113-119 angiotensin converting enzyme 2 Homo sapiens 22-26 35458513-3 2022 Accordingly, point mutations that result in an increase in electropositively charged residues, e.g., arginine and lysine, especially in the RBD of spike proteins in the SARS-CoV-2 variants, could contribute to their spreading capacity by favoring their recognition by the electronegatively charged ACE2 receptors. Lysine 114-120 angiotensin converting enzyme 2 Homo sapiens 298-302 35458513-5 2022 Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2. Lysine 0-6 angiotensin converting enzyme 2 Homo sapiens 66-70 35458513-5 2022 Lysine and arginine residues also participate in the enhanced RBD-ACE2 binding affinity of the omicron variant, by creating additional salt bridges with aspartic and glutamic acid residues from ACE2. Lysine 0-6 angiotensin converting enzyme 2 Homo sapiens 194-198 35458513-6 2022 However, the effects of lysine- and arginine-generating point mutations on infectivity is more contrasted, since the overall binding affinity of omicron RBD for ACE2 apparently results from some epistasis among the whole set of point mutations. Lysine 24-30 angiotensin converting enzyme 2 Homo sapiens 161-165 35321335-4 2022 The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2. Lysine 66-72 angiotensin converting enzyme 2 Homo sapiens 246-250 35321335-4 2022 The computational analysis, considering the case in which all the lysine residues in the system are subjected to non-enzymatic glycation, confirmed that lysine glycation causes a general loss of interactivity between wild-type (WT)-Spike-RBD and ACE2. Lysine 153-159 angiotensin converting enzyme 2 Homo sapiens 246-250 35046573-3 2022 Several mAbs (LY-CoV555, LY-CoV016, REGN10933, REGN10987 and CT-P59) completely lost neutralizing activity against B.1.1.529 virus in both Vero-TMPRSS2 and Vero-hACE2-TMPRSS2 cells, whereas others were reduced (COV2-2196 and COV2-2130 combination, ~12-fold decrease) or minimally affected (S309). Lysine 14-16 angiotensin converting enzyme 2 Homo sapiens 161-166 33583954-2 2021 The results of molecular docking positioned four molecules at the interaction site Tyr-491(Spike)-Glu-37(ACE2) and one at the site Gly-488(Spike)-Lys-353(ACE2). Lysine 146-149 angiotensin converting enzyme 2 Homo sapiens 154-158 33657325-7 2021 This weakening of binding strength was observed to be due to the destabilization of the interactions between ACE2 residues Glu-35, Glu-37, Tyr-83, Lys-353, and Arg-393 and the SARS-CoV-2 s-protein receptor binding domain (RBD). Lysine 147-150 angiotensin converting enzyme 2 Homo sapiens 109-113 33962629-14 2021 In vitro exposure of monomeric hACE2 to 120 mM glucose for 12 days led to non-enzymatic glycation of four lysine residues in the neck domain affecting the protein oligomerization. Lysine 106-112 angiotensin converting enzyme 2 Homo sapiens 31-36 33951227-4 2021 It was found that the binding of ACE2 to SARS-CoV-2-RBD involved two core regions (31st and 353rd lysine) and 20 amino acids of the ACE2 protein. Lysine 98-104 angiotensin converting enzyme 2 Homo sapiens 33-37 32448098-8 2021 The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD. Lysine 141-144 angiotensin converting enzyme 2 Homo sapiens 187-191 33254553-4 2020 In fact, in a single ACE2 molecule, 34 lysine residues are present in the extracellular portion, and at least one of these is co-involved in a fundamental hydrogen-bond interaction with the SARS-CoV-2 receptor binding domain (RBD). Lysine 39-45 angiotensin converting enzyme 2 Homo sapiens 21-25 32448098-8 2021 The major hot spot amino acids involved in the binding identified by interaction analysis after simulations includes Glu 35, Tyr 83, Asp 38, Lys 31, Glu 37, His 34 amino acid residues of ACE2 receptor and Gln 493, Gln 498, Asn 487, Tyr 505 and Lys 417 residues in nCoV S-protein RBD. Lysine 244-247 angiotensin converting enzyme 2 Homo sapiens 187-191 33200028-4 2020 Here, we observed Val-to-Lys417 mutation in the receptor-binding domains (RBD) of SARS-CoV-2, which established a Lys-Asp electrostatic interaction enhancing its ACE2-binding. Lysine 114-118 angiotensin converting enzyme 2 Homo sapiens 162-166