PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19074853-5 2008 A lysine-less cyclin D1 species was resistant to these effects. Lysine 2-8 cyclin D1 Homo sapiens 14-23 11884610-6 2002 While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4. Lysine 138-141 cyclin D1 Homo sapiens 22-31 17310991-4 2007 Eighteen lysines in cyclin D1 had single, double or multiple mutations engineered before transfection into BEAS-2B human bronchial epithelial (HBE) cells to evaluate stabilities after all-trans-retinoic acid (RA) or cycloheximide treatments. Lysine 9-16 cyclin D1 Homo sapiens 20-29 17310991-5 2007 Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life. Lysine 68-75 cyclin D1 Homo sapiens 30-39 17310991-5 2007 Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life. Lysine 68-75 cyclin D1 Homo sapiens 166-175 17310991-6 2007 Mutation of all cyclin D1 lysines blocked polyubiquitination. Lysine 26-33 cyclin D1 Homo sapiens 16-25 16568089-7 2006 Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression. Lysine 30-36 cyclin D1 Homo sapiens 166-175 12810706-4 2003 Furthermore, mutation of this lysine relieves the repression of the cyclin D1 promoter by C/EBP beta-1 without altering the subnuclear localization of C/EBP beta-1. Lysine 30-36 cyclin D1 Homo sapiens 68-77 22028615-7 2011 WHSC1 interacts with some proteins related to the WNT pathway including beta-catenin and transcriptionally regulates CCND1, the target gene of the beta-catenin/Tcf-4 complex, through histone H3 at lysine 36 trimethylation. Lysine 197-203 cyclin D1 Homo sapiens 117-122 28098854-7 2017 This is because the inhibition of LSD1 induces dimethylation of lysine 9 on histone H3 (H3K9m2) accumulation at the promoter region of cyclin D1. Lysine 64-70 cyclin D1 Homo sapiens 135-144 24342356-5 2014 Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIalpha down-regulation of cyclin D1 protein expression and that MEK1/2-Erk was a specific downstream target of SUMOylated RhoGDIalpha for its inhibition of C-Jun/AP-1 cascade, cyclin d1 transcription, and cell cycle progression. Lysine 43-46 cyclin D1 Homo sapiens 99-108 22905217-4 2012 Mutation of SUMO acceptor lysines 159 and 279 located in the C-terminal repression domain has no impact on nuclear localization; however, it abrogates association with the co-repressor histone deacetylase 1 (HDAC1), attenuates repression of cyclin D1, and prevents Stra13-mediated growth suppression. Lysine 26-33 cyclin D1 Homo sapiens 241-250 19767775-0 2009 Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. Lysine 0-6 cyclin D1 Homo sapiens 28-37 20109579-8 2010 Furthermore, we show that though the level of methyltransferases enzymes was increased, the status of H3 three-methylation at lysine 27 (H3K27me(3)), associated with gene repression on the promoter of Cyclin D1, was lower. Lysine 126-132 cyclin D1 Homo sapiens 201-210 20798689-4 2011 The lysine residue, K33, of cyclin D1 is a key site for this newly identified regulation. Lysine 4-10 cyclin D1 Homo sapiens 28-37 19767775-3 2009 We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1. Lysine 29-35 cyclin D1 Homo sapiens 61-70 19767775-3 2009 We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1. Lysine 29-35 cyclin D1 Homo sapiens 207-216 19767775-4 2009 The work described herein reveals a requisite role for Lys-269 (K269) for the rapid polyubiquitin-mediated degradation of cyclin D1. Lysine 55-58 cyclin D1 Homo sapiens 122-131 19767775-5 2009 Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation. Lysine 12-15 cyclin D1 Homo sapiens 92-101 19767775-5 2009 Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation. Lysine 12-15 cyclin D1 Homo sapiens 123-132 19767775-5 2009 Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation. Lysine 12-15 cyclin D1 Homo sapiens 123-132 19767775-7 2009 Strikingly, although mutation of lysine 269 to arginine inhibits cyclin D1 degradation, it does not inhibit cyclin D1 ubiquitylation in vivo, showing that ubiquitylation of a specific lysine can influence substrate targeting to the 26S proteasome. Lysine 33-39 cyclin D1 Homo sapiens 65-74 19506034-3 2009 In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner. Lysine 146-152 cyclin D1 Homo sapiens 14-23