PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27590836-6 2017 In the intermediate scenario, IFN-free DAAs for stages F0-F4 had a favorable cost-effectiveness profile vs IFN-based or IFN-free treatment strategies for F2-F4 and offered the greatest return on investment (0.899 LYs gained in SVR and 0.933 QALYs per $10,000 invested). Lysine 213-216 interferon alpha 1 Homo sapiens 30-33 29627904-4 2018 The 166 amino acids polypeptide chain of IFN beta-1a contains 11 Lys and 11 Gln residues potential sites of TGase derivatization. Lysine 65-68 interferon alpha 1 Homo sapiens 41-44 25122677-4 2014 We analyzed genome-wide histone H3 lysine 4 methylation and gene expression in thyroid cells induced by IFNalpha, a key cytokine secreted during viral infections, and overlapped them with known GD-associated SNPs. Lysine 35-41 interferon alpha 1 Homo sapiens 104-112 27666593-4 2016 The induction of TRIM14 by type I IFN accelerates cGAS stabilization by recruiting USP14 to cleave the ubiquitin chains of cGAS at lysine (K) 414. Lysine 131-137 interferon alpha 1 Homo sapiens 34-37 25581111-8 2015 Treatment only for patients at stages F3-F4 with IFN-free therapies would increase LYS by 16.7% versus SE0 in Egypt, 22.0% versus ST0 in Thailand, and 13.1% versus SC0 in Cote d"Ivoire. Lysine 83-86 interferon alpha 1 Homo sapiens 49-52 19454348-1 2009 The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity. Lysine 37-43 interferon alpha 1 Homo sapiens 144-167 24399297-2 2014 Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta. Lysine 14-20 interferon alpha 1 Homo sapiens 283-292 24399297-2 2014 Attachment of lysine 63 (Lys(63))-linked ubiquitin chains to the RNA sensor retinoic acid-inducible gene-I (RIG-I) by the ubiquitin E3 ligase tripartite motif protein 25 (TRIM25) leads to the activation of RIG-I and stimulates production of the antiviral cytokines interferon-alpha (IFN-alpha) and IFN-beta. Lysine 25-28 interferon alpha 1 Homo sapiens 283-292 24068929-6 2013 This cell culture system allowed us to demonstrate that cccDNA transcription required histone deacetylase activity and IFN-alpha induced a profound and long-lasting suppression of cccDNA transcription, which required protein synthesis and was associated with the reduction of acetylated histone H3 lysine 9 (H3K9) and 27 (H3K27) in cccDNA minichromosomes. Lysine 298-304 interferon alpha 1 Homo sapiens 119-128 22033337-4 2011 Our results show that virus infection induces p53 acetylation at lysine 379, and that this modification is absolutely required for p53-dependent transcriptional transactivation of both, pro-apoptotic and IFN-stimulated genes induced by virus infection, and for p53-mediated control of virus replication. Lysine 65-71 interferon alpha 1 Homo sapiens 204-207 19366580-5 2009 Using a recombinant infectious clone of RP-9, we found that a single Glu-->Lys mutation at residue 138 of the envelope protein (E-E138K) rendered the mutated RP-9 sensitive to the antiviral effect of IFN-alpha. Lysine 78-81 interferon alpha 1 Homo sapiens 203-212 22412156-0 2012 Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response. Lysine 11-17 interferon alpha 1 Homo sapiens 69-79 22412156-4 2012 We identify di-methylation of histone H3 at lysine 9 (H3K9me2) as a suppressor of IFN and IFN-inducible antiviral gene expression. Lysine 44-50 interferon alpha 1 Homo sapiens 82-85 22412156-4 2012 We identify di-methylation of histone H3 at lysine 9 (H3K9me2) as a suppressor of IFN and IFN-inducible antiviral gene expression. Lysine 44-50 interferon alpha 1 Homo sapiens 90-93 21167755-3 2010 RAUL limited type I IFN production by directly catalyzing lysine 48-linked polyubiquitination of both interferon regulatory factor 7 (IRF7) and IRF3 followed by proteasome-dependent degradation. Lysine 58-64 interferon alpha 1 Homo sapiens 20-23 20071582-11 2010 While Thr-170 phosphorylation keeps RIG-I latent, Lys-172 ubiquitination enables RIG-I to form a stable complex with MAVS, thereby inducing IFN signal transduction. Lysine 50-53 interferon alpha 1 Homo sapiens 140-143 15898716-3 2005 This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side chain of IFNalpha(2a). Lysine 139-145 interferon alpha 1 Homo sapiens 27-35 15898716-3 2005 This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side chain of IFNalpha(2a). Lysine 139-145 interferon alpha 1 Homo sapiens 49-57 15898716-3 2005 This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side chain of IFNalpha(2a). Lysine 139-145 interferon alpha 1 Homo sapiens 49-57 2459270-1 1988 A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Lysine 100-113 interferon alpha 1 Homo sapiens 27-37 11150296-0 2001 Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. Lysine 9-15 interferon alpha 1 Homo sapiens 55-65 11150296-8 2001 The results suggest that two arginine/lysine-rich elements, one in each STAT monomer, are required for IFN-induced nuclear import of STAT dimers. Lysine 38-44 interferon alpha 1 Homo sapiens 103-106 1379290-1 1992 Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS). Lysine 78-91 interferon alpha 1 Homo sapiens 0-10 1379290-1 1992 Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS). Lysine 78-91 interferon alpha 1 Homo sapiens 12-15 15898717-4 2005 This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a). Lysine 139-145 interferon alpha 1 Homo sapiens 27-35 15898717-4 2005 This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a). Lysine 139-145 interferon alpha 1 Homo sapiens 49-57 15898717-4 2005 This 40 kDa PEG-conjugated IFNalpha(2a) ((40)PEG-IFNalpha(2a)) is obtained by the covalent binding of one 40 kDa branched PEG-polymer to a lysine side-chain of IFNalpha(2a). Lysine 139-145 interferon alpha 1 Homo sapiens 49-57 9758677-1 1998 Palmitoyl derivatives of interferon alpha2b (p-IFNalpha) were prepared by covalent attachment of the fatty acid to lysine residues in the protein through a reaction with N-hydroxysuccinimide palmitate ester. Lysine 115-121 interferon alpha 1 Homo sapiens 47-55 2817813-15 1989 IFN alpha J and IFN-alpha 7 differ only by one amino acid, at position 107, where a lysine in IFN-alpha J has been replaced by a glutamic acid in the IFN-alpha 7. Lysine 84-90 interferon alpha 1 Homo sapiens 0-9 2817813-15 1989 IFN alpha J and IFN-alpha 7 differ only by one amino acid, at position 107, where a lysine in IFN-alpha J has been replaced by a glutamic acid in the IFN-alpha 7. Lysine 84-90 interferon alpha 1 Homo sapiens 16-25 2459270-1 1988 A preliminary trial of the interferon (IFN) inducer polyriboinosinic acid-polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) was conducted in patients with chronic progressive multiple sclerosis (MS). Lysine 100-113 interferon alpha 1 Homo sapiens 39-42 32101556-2 2020 A peptide from C-terminus of interferon alpha1, conjugated to palmitoyl-lysine for cell penetration, denoted as IFNalpha-C, was tested for its anti-inflammatory properties in ARPE-19 cells, followed by testing in a mouse model of EAU. Lysine 72-78 interferon alpha 1 Homo sapiens 29-46 2964368-13 1988 Examination of these sequences reveals that Lys-84 is present in all the IFN-alpha except IFN-alpha B where it is replaced by Glu; and Tyr-90, present in most of the common IFN-alpha including alpha A and alpha D, is replaced by Asp in IFN-alpha B. Lysine 44-47 interferon alpha 1 Homo sapiens 73-82 2964368-13 1988 Examination of these sequences reveals that Lys-84 is present in all the IFN-alpha except IFN-alpha B where it is replaced by Glu; and Tyr-90, present in most of the common IFN-alpha including alpha A and alpha D, is replaced by Asp in IFN-alpha B. Lysine 44-47 interferon alpha 1 Homo sapiens 90-99 2437225-2 1986 In contrast, LO-22 bound strongly to IFN-alpha 2 (IFN-alpha 2b) and IFN-alpha 2C (IFN-alpha 2c) which differ by one or two amino acids, respectively, from IFN-alpha A; the latter has lysine at position 23 whereas the other closely related IFNs have arginine. Lysine 183-189 interferon alpha 1 Homo sapiens 37-46 2414373-1 1985 Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS). Lysine 78-91 interferon alpha 1 Homo sapiens 0-10 2414373-1 1985 Interferon (IFN) responses to polyriboinosinic acid polyribocytidylic acid in poly-L-lysine and carboxymethylcellulose (poly ICLC) have been studied in detail in 6 men and 3 women as part of a preliminary trial in patients with multiple sclerosis (MS). Lysine 78-91 interferon alpha 1 Homo sapiens 12-15 6201567-0 1984 Interferon response to poly IC/poly-L-lysine in normal and lymphocyte-suppressed primates. Lysine 31-44 interferon alpha 1 Homo sapiens 0-10 6201567-1 1984 Grivet monkeys immunosuppressed with either cyclophosphamide or methylprednisolone retain their capacity to produce interferon in response to poly I:C/poly-L-lysine (poly ICL). Lysine 151-164 interferon alpha 1 Homo sapiens 116-126