PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29362093-7	2018	A molecular dynamics analysis of the Arg376 > Lys mutation based on the CYP3A4 (a human CYP450) protein structure found that it was responsible for the increase in axis length toward the heme (active site), which is critically important for biological activity and ligand binding.	Lysine	49-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81	
31535851-10	2020	Adduct formation with different hepatic and plasma proteins was investigated by LC-MS/MS and adducts between pazopanib or sunitinib aldehyde derivatives and lysine residues on both CYP3A4 and plasma proteins were indeed shown for the first time.	Lysine	157-163	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	181-187	
28546420-4	2017	We found that the induction of CYP3A4 mRNA (4- to 15-fold) by rifampicin in LS174T cells was associated with increased levels of histone H3 lysine 4 trimethylation (H3K4me3, above 1.8-fold) and H3 acetylation (above 2-fold) and a decreased level of histone H3 lysine 27 trimethylation (H3K27me3, about 50%) in the CYP3A4 promoter.	Lysine	140-146	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-37	
28546420-4	2017	We found that the induction of CYP3A4 mRNA (4- to 15-fold) by rifampicin in LS174T cells was associated with increased levels of histone H3 lysine 4 trimethylation (H3K4me3, above 1.8-fold) and H3 acetylation (above 2-fold) and a decreased level of histone H3 lysine 27 trimethylation (H3K27me3, about 50%) in the CYP3A4 promoter.	Lysine	260-266	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-37	
25451919-4	2015	Intriguingly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, leading us to propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination.	Lysine	53-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	265-271	
33674270-7	2021	Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown.	Lysine	74-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	124-130	
34949673-9	2022	Mechanistically, enrichment of PXR and trimethylation of histone 3 lysine 4 (H3K4me3) in the CYP3A4 promoter was increased, and trimethylation of histone 3 lysine 27 (H3K27me3) was decreased after HNF4A-AS1 knockdown.	Lysine	67-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99	
33674270-7	2021	Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown.	Lysine	74-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	167-173