PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29362093-7 2018 A molecular dynamics analysis of the Arg376 > Lys mutation based on the CYP3A4 (a human CYP450) protein structure found that it was responsible for the increase in axis length toward the heme (active site), which is critically important for biological activity and ligand binding. Lysine 49-52 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 75-81 31535851-10 2020 Adduct formation with different hepatic and plasma proteins was investigated by LC-MS/MS and adducts between pazopanib or sunitinib aldehyde derivatives and lysine residues on both CYP3A4 and plasma proteins were indeed shown for the first time. Lysine 157-163 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 181-187 28546420-4 2017 We found that the induction of CYP3A4 mRNA (4- to 15-fold) by rifampicin in LS174T cells was associated with increased levels of histone H3 lysine 4 trimethylation (H3K4me3, above 1.8-fold) and H3 acetylation (above 2-fold) and a decreased level of histone H3 lysine 27 trimethylation (H3K27me3, about 50%) in the CYP3A4 promoter. Lysine 140-146 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 31-37 28546420-4 2017 We found that the induction of CYP3A4 mRNA (4- to 15-fold) by rifampicin in LS174T cells was associated with increased levels of histone H3 lysine 4 trimethylation (H3K4me3, above 1.8-fold) and H3 acetylation (above 2-fold) and a decreased level of histone H3 lysine 27 trimethylation (H3K27me3, about 50%) in the CYP3A4 promoter. Lysine 260-266 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 31-37 25451919-4 2015 Intriguingly, CYP3A4 Ser(P)/Thr(P) and ubiquitinated Lys residues reside within the cytosol-accessible surface loop and/or conformationally assembled acidic Asp/Glu clusters, leading us to propose that such post-translational Ser/Thr protein phosphorylation primes CYP3A4 for ubiquitination. Lysine 53-56 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 265-271 33674270-7 2021 Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown. Lysine 74-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 124-130 34949673-9 2022 Mechanistically, enrichment of PXR and trimethylation of histone 3 lysine 4 (H3K4me3) in the CYP3A4 promoter was increased, and trimethylation of histone 3 lysine 27 (H3K27me3) was decreased after HNF4A-AS1 knockdown. Lysine 67-73 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 93-99 33674270-7 2021 Strikingly, our data showed that increased enrichment levels of histone 3 lysine 4 timethylation (H3K4me3) and HNF4A in the CYP3A4 promoter contribute to the elevated CYP3A4 expression after HNF4A-AS1 knockdown. Lysine 74-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 167-173