PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15632126-3 2005 We demonstrate that ubiquitination of histone H2B on lysine 123 by the Rad6-Bre1 complex, is necessary for activation of Rad53 kinase and cell cycle arrest. Lysine 53-59 checkpoint kinase 2 Mus musculus 121-126 31209362-4 2020 Specifically, SIRT1 interacts with CHK2 and deacetylates it at lysine 520 residue, which suppresses CHK2 phosphorylation, dimerization, and thus activation. Lysine 63-69 checkpoint kinase 2 Mus musculus 35-39 31209362-4 2020 Specifically, SIRT1 interacts with CHK2 and deacetylates it at lysine 520 residue, which suppresses CHK2 phosphorylation, dimerization, and thus activation. Lysine 63-69 checkpoint kinase 2 Mus musculus 100-104