PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8346241-0 1993 The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Lysine 73-80 interleukin 1 alpha Homo sapiens 24-43 8346241-7 1993 To determine which lysine(s) are acylated, a series of synthetic peptides containing all lysines found in the IL-1 alpha N-terminal propiece were used in an in vitro myristoylation assay containing peptide, myristoyl-CoA, and monocyte lysate as enzyme source. Lysine 89-96 interleukin 1 alpha Homo sapiens 110-120 8346241-4 1993 We report that the N terminus of the 31-kDa IL-1 alpha precursor is myristoylated on specific internal lysine residues. Lysine 103-109 interleukin 1 alpha Homo sapiens 44-54 20074553-4 2010 In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway. Lysine 58-64 interleukin 1 alpha Homo sapiens 107-111 2198282-10 1990 We found that functional hIL-1 alpha had an absolute requirement for a basic residue (Arg, Lys, or His) at either position 15 or 16, and that Leu was preferred at position 40. Lysine 91-94 interleukin 1 alpha Homo sapiens 25-36 31420217-5 2019 Mechanistically, SAM generation maintains a relatively high SAM:S-adenosylhomocysteine ratio to support histone H3 lysine 36 trimethylation for IL-1beta production. Lysine 115-121 interleukin 1 alpha Homo sapiens 144-152 20074553-4 2010 In addition, the degradation of non-ubiquitinated form of lysine less mutant p21-K6R was also inhibited by IL-1, suggesting that IL-1 stabilized p21 protein via ubiquitin-independent pathway. Lysine 58-64 interleukin 1 alpha Homo sapiens 129-133 9507015-6 1998 Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression. Lysine 17-30 interleukin 1 alpha Homo sapiens 78-82 10547156-7 1999 Poly-L-lysine, but not poly-L-glutamic acid dose-dependently increased the urinary excretion of IL-1alpha. Lysine 0-13 interleukin 1 alpha Homo sapiens 96-105 19112497-7 2008 Furthermore, lysine-deficient TRAF6 rescued IL-1-mediated NFkappaB and MAPK activation, as well as IL-6 elaboration in retrovirally-rescued TRAF6-deficient fibroblasts. Lysine 13-19 interleukin 1 alpha Homo sapiens 44-48 17449468-5 2007 The NZF domains of TAB2/3 are critical for TAB2/3 to bind to Lys(63)-linked polyubiquitin chains of other adaptor proteins, such as receptor-interacting protein and TRAF6, which are two signaling proteins essential for TNF- and IL-1-induced NF-kappaB activation, respectively. Lysine 61-64 interleukin 1 alpha Homo sapiens 228-232 16996234-0 2006 Determination of interleukin-1alpha in human NCTC 2544 keratinocyte cells as a predictor of skin irritation from lysine-based surfactants. Lysine 113-119 interleukin 1 alpha Homo sapiens 17-35 16996234-5 2006 Lysine derivatives proved to be less potent in stimulating IL-1 alpha synthesis and induced a lower release of this cytokine into the culture medium when compared to the anionic surfactant sodium dodecyl sulfate. Lysine 0-6 interleukin 1 alpha Homo sapiens 59-69 9507015-10 1998 The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin. Lysine 123-136 interleukin 1 alpha Homo sapiens 33-37 9507015-10 1998 The focal adhesion dependence of IL-1-induced ERK activation and c-fos expression could be circumvented in cells plated on poly-L-lysine by simultaneous incubation with IL-1 and the calcium ionophore ionomycin. Lysine 123-136 interleukin 1 alpha Homo sapiens 169-173 7590907-1 1995 The octapeptide Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg (termed leukocorticotropin, LCT) corresponding to the ACTH-like sequence 81-88 of human pro-interleukin-1 alpha and its derivative Tyr-Gly-Lys-Val-Leu-Lys-Lys-Arg-Arg were synthesized. Lysine 20-23 interleukin 1 alpha Homo sapiens 136-159