PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14593114-6 2004 In the presence of the ubiquitin-conjugating enzyme UBC7, the RING-H2 finger has in vitro ubiquitination activity for Lys(48)-specific polyubiquitin linkage, suggesting that human HRD1 is an E3 ubiquitin ligase involved in protein degradation. Lysine 118-121 synoviolin 1 Homo sapiens 180-184 32094691-7 2020 We identify two binding sites for misfolded proteins in Hrd1, a low-affinity luminal site and a high-affinity cytoplasmic site formed following auto-ubiquitination of specific lysine residues in Hrd1"s RING domain. Lysine 176-182 synoviolin 1 Homo sapiens 56-60 32094691-7 2020 We identify two binding sites for misfolded proteins in Hrd1, a low-affinity luminal site and a high-affinity cytoplasmic site formed following auto-ubiquitination of specific lysine residues in Hrd1"s RING domain. Lysine 176-182 synoviolin 1 Homo sapiens 195-199 28121484-10 2017 Interestingly, SYVN1-mediated lysine 48 (K48)-linked polyubiquitin chains that conjugated onto SERPINA1E342K/ATZ might predominantly bind to the ubiquitin-associated (UBA) domain of SQSTM1 and couple the ubiquitinated SERPINA1E342K/ATZ to the lysosome for degradation. Lysine 30-36 synoviolin 1 Homo sapiens 15-20