PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20837137-0 2011 TAK1 lysine 158 is required for TGF-beta-induced TRAF6-mediated Smad-independent IKK/NF-kappaB and JNK/AP-1 activation. Lysine 5-11 mitogen-activated protein kinase 8 Homo sapiens 99-102 22924711-7 2012 LPS increased p38 MAPK and JNK phosphorylation at 4 and 2-4 h, respectively, whereas treatment reduced p38 MAPK and JNK phosphorylation only at 2 h. In addition, treatment reversed the LPS-induced elevation of NF-kappaB p65 protein and phosphorylation at serine 468 and induced acetylation at lysine 310. Lysine 293-299 mitogen-activated protein kinase 8 Homo sapiens 116-119 22902619-7 2012 Loss of Lys-30 ubiquitination of SLP-76 results in enhanced anti-CD3 antibody-induced ERK and JNK activation. Lysine 8-11 mitogen-activated protein kinase 8 Homo sapiens 94-97 22184250-5 2012 Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation. Lysine 15-21 mitogen-activated protein kinase 8 Homo sapiens 142-146 22184250-5 2012 Replacement of Lysine 388 and Lysine 472 by arginines generates a nondegradable Miz1 mutant, which significantly suppresses TNF-alpha-induced JNK1 activation and inflammation. Lysine 30-36 mitogen-activated protein kinase 8 Homo sapiens 142-146 21921033-6 2011 We find that the MAP 3-kinase MEKK1 acts as a novel TTP kinase that, together with the TNF receptor-associated factor 2 (TRAF2), constitutes not only a main determinate of the NF-kappaB-JNK cross-talk but also facilitates "TTP hypermodification": MEKK1 triggers TTP phosphorylation as prerequisite for its Lys-63-linked, TRAF2-mediated ubiquitination. Lysine 306-309 mitogen-activated protein kinase 8 Homo sapiens 186-189 20837137-4 2011 Here we report that lysine 158 on TAK1 is required for TGF-beta-induced TRAF6-mediated TAK1 polyubiquitination and TAK1-mediated IKK, JNK and p38 activation. Lysine 20-26 mitogen-activated protein kinase 8 Homo sapiens 134-137 19927120-1 2009 TAB2 and TAB3 activate the Jun N-terminal kinase and nuclear factor-kappaB pathways through the specific recognition of Lys 63-linked polyubiquitin chains by its Npl4 zinc-finger (NZF) domain. Lysine 120-123 mitogen-activated protein kinase 8 Homo sapiens 27-48 20484055-5 2010 Tubulin hyperacetylation on lysine 40 enhances kinesin-1 and JIP-1 recruitment on microtubules and allows JNK phosphorylation and activation. Lysine 28-34 mitogen-activated protein kinase 8 Homo sapiens 106-109 19737936-6 2009 The JNK substrate Itch (a HECT domain-containing Nedd4-like ubiquitin protein ligase) bound to MKK4, ubiquitinated lysines 140 and 143, and promoted MKK4 degradation. Lysine 115-122 mitogen-activated protein kinase 8 Homo sapiens 4-7 19041150-6 2009 In addition, an association of JNK1 activation with the histone H3 lysines 4 and 9 tri-methylation was observed in the HCC tissues, which leads to an elevated expression of genes regulating cell growth and a decreased expression of the genes for cell differentiation and the p450 family members in HCC. Lysine 67-74 mitogen-activated protein kinase 8 Homo sapiens 31-35 16176806-7 2005 However, the phosphorylation of c-Jun NH(2)-terminal kinase 1 (JNK1) was found to increase in both triptolide- and LY-294002-treated cells. Lysine 115-117 mitogen-activated protein kinase 8 Homo sapiens 32-61 18337589-6 2008 S246 GR phosphorylation by JNK facilitated subsequent GR sumoylation at lysines 297 and 313. Lysine 72-79 mitogen-activated protein kinase 8 Homo sapiens 27-30 18439917-4 2008 Using human aortic smooth muscle cells, we found that TNFalpha activated the MKK4-JNK1 pathway, which induced histone (H) 4 lysine 12 acetylation within the TNFalpha response element in the P4Halpha1 promoter. Lysine 124-130 mitogen-activated protein kinase 8 Homo sapiens 82-86 18093184-0 2008 Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process. Lysine 75-78 mitogen-activated protein kinase 8 Homo sapiens 93-96 16176806-7 2005 However, the phosphorylation of c-Jun NH(2)-terminal kinase 1 (JNK1) was found to increase in both triptolide- and LY-294002-treated cells. Lysine 115-117 mitogen-activated protein kinase 8 Homo sapiens 63-67 12591902-10 2003 Mutation of the lysine residue within the transmembrane domain of CD158j abolished JNK activation, suggesting that an alternate adaptor molecule was being used. Lysine 16-22 mitogen-activated protein kinase 8 Homo sapiens 83-86 15958389-6 2005 HIPK2 with a mutated SUMO acceptor lysine residue was refractory to inhibition of HIPK2-mediated JNK activation by SUMO-1. Lysine 35-41 mitogen-activated protein kinase 8 Homo sapiens 97-100 15850772-9 2005 Collectively, these findings demonstrate that inactivation of MAPK, Akt, and activation of the JNK pathway contributes to the induction of apoptosis induced by fludarabine/LY. Lysine 172-174 mitogen-activated protein kinase 8 Homo sapiens 95-98 10823834-8 2000 Cells plated on poly-l-lysine (to prevent the formation of focal adhesions) showed activation only of JNK and p38. Lysine 16-29 mitogen-activated protein kinase 8 Homo sapiens 102-105 9275185-7 1997 Interestingly, deletion of amino acids 353-835 in the putative C-terminal regulatory region, or mutation of Lys-35 in the putative ATP-binding domain, markedly reduced the ability of GLK to activate JNK. Lysine 108-111 mitogen-activated protein kinase 8 Homo sapiens 199-202 10409755-9 1999 Transient expression of a dominant negative mutant SEK1 (Lys-->Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis. Lysine 57-60 mitogen-activated protein kinase 8 Homo sapiens 94-97 10409755-9 1999 Transient expression of a dominant negative mutant SEK1 (Lys-->Arg), an upstream kinase of JNK, prevented both TG-induced JNK activation and apoptosis. Lysine 57-60 mitogen-activated protein kinase 8 Homo sapiens 125-128 9452508-5 1998 Transient expression of a dominant negative mutant SEK1(Lys --> Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis. Lysine 56-59 mitogen-activated protein kinase 8 Homo sapiens 95-98 9452508-5 1998 Transient expression of a dominant negative mutant SEK1(Lys --> Arg), an upstream kinase of JNK, prevents both DA-induced JNK activation and apoptosis. Lysine 56-59 mitogen-activated protein kinase 8 Homo sapiens 125-128 35224496-5 2022 Additionally, the simulations prospectively predicted several druggable cysteine and lysine sites, including the alphaH head cysteine in JNK1/3 and DFG + 6 cysteine in JNK2, corroborating the chemical proteomic screening data. Lysine 85-91 mitogen-activated protein kinase 8 Homo sapiens 137-143 28753655-5 2017 NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation. Lysine 73-76 mitogen-activated protein kinase 8 Homo sapiens 13-16 28753655-5 2017 NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation. Lysine 73-76 mitogen-activated protein kinase 8 Homo sapiens 91-94 28753655-5 2017 NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation. Lysine 73-76 mitogen-activated protein kinase 8 Homo sapiens 104-108 28753655-5 2017 NleL-induced JNK ubiquitylation, particularly mono-ubiquitylation at the Lys 68 residue of JNK, impairs JNK"s interaction with an upstream kinase MKK7, thus disrupting JNK phosphorylation and activation. Lysine 73-76 mitogen-activated protein kinase 8 Homo sapiens 91-94 25056949-4 2014 This regulatory function toward JNK activation but not NF-kappaB activation depends on lysine 105 of TTP, which we identified as the corresponding TRAF2 ubiquitination site. Lysine 87-93 mitogen-activated protein kinase 8 Homo sapiens 32-35 32460017-5 2020 Upon DC activation, JNK signaling stimulated p300 association with PKM2 for the acetylation of lysine 433, a classic posttranslational modification critical for PKM2 destabilization and nuclear re-localization. Lysine 95-101 mitogen-activated protein kinase 8 Homo sapiens 20-23 26651941-5 2015 Surprisingly, JNK-mediated viral gene induction occurs independently of histone demethylases that remove repressive lysine modifications. Lysine 116-122 mitogen-activated protein kinase 8 Homo sapiens 14-17 26651941-6 2015 Rather, JNK signaling results in a histone methyl/phospho switch on HSV lytic promoters, a mechanism permitting gene expression in the presence of repressive lysine methylation. Lysine 158-164 mitogen-activated protein kinase 8 Homo sapiens 8-11 26189595-0 2015 Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Lysine 83-89 mitogen-activated protein kinase 8 Homo sapiens 126-129