PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15729708-4 2005 Activation of the DOTA molecule, resulting in 1,4,7,10-tetraazacyclododecane-N,N",N"",N"""-tetraacetic acid mono-(N-hydroxysuccinimidyl) ester (DOTA-NHS), allows conjugation with the anti-PSMA antibody through lysine residues in the antibody. Lysine 210-216 folate hydrolase 1 Homo sapiens 188-192 17032155-2 2006 We coupled anti-PSMA monoclonal antibody with poly-L-lysine and then incubated it with plasmids. Lysine 46-59 folate hydrolase 1 Homo sapiens 16-20 34373887-6 2021 PSMA-targeting ligands (i.e., glutamate-urea-lysine derivatives called KuEs) and fluorescent or radiolabelled prosthetic groups were grafted onto the UCNP surface by strain-promoted azide-alkyne cycloaddition (SPAAC). Lysine 45-51 folate hydrolase 1 Homo sapiens 0-4 34800176-2 2022 The PSMA ligand developed based on the Glu-urea-Lys structure was linked to FITC by aminocaproic acid (Ahx) to obtain PSMA-FITC. Lysine 48-51 folate hydrolase 1 Homo sapiens 4-8 34648046-1 2022 PURPOSE: We planned this prospective study to evaluate PSMA expression in recurrent high-grade gliomas (rHGG), including anaplastic astrocytoma and glioblastoma using Glu-NH-CO-NH-Lys-(Ahx)-(Ga-68 (HBED-CC))- (Ga-68 PSMA) positron emission tomography (PET), with its theranostic potential in mind. Lysine 180-183 folate hydrolase 1 Homo sapiens 55-59 33459068-4 2021 AREA COVERED: This review includes WIPO-listed patents (from January 2017 to June 2020) reporting PSMA-targeted probes based on the Lys-urea-Glu or Glu-urea-Glu structure. Lysine 132-135 folate hydrolase 1 Homo sapiens 98-102 35467350-6 2022 The docking calculations and molecular dynamics simulations showed how 1 enters the PSMA funnel region and how pharmacophore Glu-urea-Lys interacts with the arginine patch, the S1", and S1 subpockets by forming hydrogen and van der Waals bonds. Lysine 134-137 folate hydrolase 1 Homo sapiens 84-88 35566085-6 2022 The PSMA ligand was developed based on the glutamine-urea-lysine (Glu-urea-Lys) structure. Lysine 75-78 folate hydrolase 1 Homo sapiens 4-8 33783213-2 2021 In this study, three 18F-labeled PSMA tracers with a more lipophilic quinoline functional spacer were designed, synthesized, and evaluated based on the Glu-Ureido-Lys binding motif. Lysine 163-166 folate hydrolase 1 Homo sapiens 33-37 32217372-7 2020 The peptides 1-3 containing Glu-Urea-Lys and Glu-GABA-Asp as pharmacophores were efficiently interacted with crystal structure of PSMA and showed the highest binding energies range from -8 to -11.2 kcal/mol. Lysine 37-40 folate hydrolase 1 Homo sapiens 130-134 33302417-2 2020 The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vector moiety and tripeptide linker with terminal amide and azide groups for subsequent addition of two different therapeutic and diagnostic agents. Lysine 69-72 folate hydrolase 1 Homo sapiens 45-49 33637585-1 2021 Introduction: 68Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA) targeting tracer used for positron emission tomography/computed tomography (PET/CT) imaging. Lysine 33-36 folate hydrolase 1 Homo sapiens 55-89 33637585-1 2021 Introduction: 68Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA) targeting tracer used for positron emission tomography/computed tomography (PET/CT) imaging. Lysine 33-36 folate hydrolase 1 Homo sapiens 91-95 32960990-8 2020 RESULTS: Nine novel PSMA ligands were synthesized by the combination of three azido compounds and three terminal acetylene-containing Glu-urea-Lys compounds. Lysine 143-146 folate hydrolase 1 Homo sapiens 20-24 29503861-0 2018 Synthesis of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand in an automated synthesis platform. Lysine 48-51 folate hydrolase 1 Homo sapiens 65-69 32097010-2 2020 The most promising PSMA-targeted agents in the clinical phase are based on the Lys-urea-Glu motif, in which Lys and Glu are alpha-(l)-amino acids. Lysine 79-82 folate hydrolase 1 Homo sapiens 19-23 32140850-1 2020 BACKGROUND: The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Lysine 72-75 folate hydrolase 1 Homo sapiens 116-150 32140850-1 2020 BACKGROUND: The positron emission tomography (PET) ligand 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) targets the prostate-specific membrane antigen (PSMA), upregulated in prostate cancer cells. Lysine 72-75 folate hydrolase 1 Homo sapiens 95-99 31502937-1 2019 Background Recent studies have reported the additive value of combined gallium 68 (68Ga)-labeled Glu-urea-Lys (Ahx)-HBED-CC ligand targeting the prostate-specific membrane antigen (PSMA) (hereafter called 68Ga-PSMA-11) PET/MRI for the detection and localization of primary prostate cancer compared with multiparametric MRI. Lysine 106-109 folate hydrolase 1 Homo sapiens 145-179 31502937-1 2019 Background Recent studies have reported the additive value of combined gallium 68 (68Ga)-labeled Glu-urea-Lys (Ahx)-HBED-CC ligand targeting the prostate-specific membrane antigen (PSMA) (hereafter called 68Ga-PSMA-11) PET/MRI for the detection and localization of primary prostate cancer compared with multiparametric MRI. Lysine 106-109 folate hydrolase 1 Homo sapiens 181-185 30485073-4 2019 Novel PSMA inhibitors were prepared using lysine as the backbone to connect three different functional groups: the glutamate-urea-lysine (GUL) structure for inhibiting PSMA, 2-nitroimidazole for the hypoxia-sensitive moiety, and a near-infrared fluorophore (sulfo-Cyanine 5.5). Lysine 42-48 folate hydrolase 1 Homo sapiens 6-10 29853810-1 2018 Objective: To synthesize 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts. Lysine 39-42 folate hydrolase 1 Homo sapiens 62-66 29853810-1 2018 Objective: To synthesize 68Ga-Glu-urea-Lys(Ahx)-HBED-CC (68Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts. Lysine 39-42 folate hydrolase 1 Homo sapiens 137-141 29448109-0 2018 HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue. Lysine 107-113 folate hydrolase 1 Homo sapiens 33-62 29448109-1 2018 Our previous study showed that the level of glutamate carboxypeptidase II (GCPII) protein is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG. Lysine 184-190 folate hydrolase 1 Homo sapiens 44-73 29448109-1 2018 Our previous study showed that the level of glutamate carboxypeptidase II (GCPII) protein is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG. Lysine 184-190 folate hydrolase 1 Homo sapiens 75-80 29448109-1 2018 Our previous study showed that the level of glutamate carboxypeptidase II (GCPII) protein is regulated by valproic acid, a histone deacetylase (HDAC) inhibitor, through acetylation of lysine residue in the GCPII protein in human astrocytes, U-87MG. Lysine 184-190 folate hydrolase 1 Homo sapiens 206-211 29448109-8 2018 Further, database search of acetylation and ubiquitination sites showed four candidate lysine sites in human GCPII protein that can be both acetylated and ubiquitinylated (K207, K479, K491, and K699). Lysine 87-93 folate hydrolase 1 Homo sapiens 109-114 29448109-9 2018 Mutation (lysine residues to arginine (R)) analysis showed that in the presence of cycloheximide K479R- and K491R-hGCPII mutants were less ubiquitinylated and degraded, and decrease in the level of GCPII protein by HDAC1 was significantly blocked by K479R mutants. Lysine 10-16 folate hydrolase 1 Homo sapiens 115-120 29448109-11 2018 Furthermore, the results also demonstrate that the stability of GCPII protein is regulated by HDAC1 through acetylation at the lysine 479 residue. Lysine 127-133 folate hydrolase 1 Homo sapiens 64-69 28833667-5 2018 Such DOTPI-TRAP conjugates were decorated with 3 Gly-urea-Lys (KuE) motifs for targeting prostate-specific membrane antigen (PSMA), employing Cu-catalyzed (CuAAC) as well as strain-promoted (SPAAC) click chemistry. Lysine 58-61 folate hydrolase 1 Homo sapiens 89-123 28833667-5 2018 Such DOTPI-TRAP conjugates were decorated with 3 Gly-urea-Lys (KuE) motifs for targeting prostate-specific membrane antigen (PSMA), employing Cu-catalyzed (CuAAC) as well as strain-promoted (SPAAC) click chemistry. Lysine 58-61 folate hydrolase 1 Homo sapiens 125-129 31248772-5 2019 In this study we describe the development of Glu-urea-Lys based PSMA-targeting conjugates with paclitaxel. Lysine 54-57 folate hydrolase 1 Homo sapiens 64-68 31009566-1 2019 Here, we present the synthesis and characterization of a new potentially nonadentate chelator H4pypa and its bifunctional analogue tBu4pypa-C7-NHS conjugated to prostate-specific membrane antigen (PSMA)-targeting peptidomimetic (Glu-urea-Lys). Lysine 238-241 folate hydrolase 1 Homo sapiens 161-195 31009566-1 2019 Here, we present the synthesis and characterization of a new potentially nonadentate chelator H4pypa and its bifunctional analogue tBu4pypa-C7-NHS conjugated to prostate-specific membrane antigen (PSMA)-targeting peptidomimetic (Glu-urea-Lys). Lysine 238-241 folate hydrolase 1 Homo sapiens 197-201 27076393-3 2016 The PSMA-targeting scaffold for all three agents utilized a similar Glu-urea-Lys-linker construct. Lysine 77-80 folate hydrolase 1 Homo sapiens 4-8 28639122-7 2017 RESULTS: F-18-labeled PSMA inhibitors were synthesized in 32-69 % radiochemical yields using (1) acylation reaction at the primary amino group of the lysine residue with [18F]SFB and (2) oxime formation with 4-[18F]fluorobenzaldehyde and [18F]FDG using the respective aminooxy-functionalized lysine residue. Lysine 150-156 folate hydrolase 1 Homo sapiens 22-26 28639122-7 2017 RESULTS: F-18-labeled PSMA inhibitors were synthesized in 32-69 % radiochemical yields using (1) acylation reaction at the primary amino group of the lysine residue with [18F]SFB and (2) oxime formation with 4-[18F]fluorobenzaldehyde and [18F]FDG using the respective aminooxy-functionalized lysine residue. Lysine 292-298 folate hydrolase 1 Homo sapiens 22-26 27847991-4 2017 METHODS: Six triazolylphenyl ureas and their alkyne precursors were synthesized from the Glu-urea-Lys PSMA binding moiety. Lysine 98-101 folate hydrolase 1 Homo sapiens 102-106 27660138-3 2017 Results were compared with pretherapeutic Glu-NH-CO-NH-Lys-(Ahx)-[68Ga(HBEDCC)] (68Ga-PSMA-HBED-CC) PET. Lysine 55-58 folate hydrolase 1 Homo sapiens 86-90 28950199-2 2017 Currently, it mainly features Gallium-68 (68Ga) labeled PSMA ligands, notably [68Ga]Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-11) and [68Ga]DOTAGA-FFK (Sub-KuE termed ([68Ga]PSMA-I&T). Lysine 93-96 folate hydrolase 1 Homo sapiens 56-60 28950199-5 2017 Here, we describe a simple synthesis and validation of a fluorine-18 labeled Glu-urea-Lys(Ahx)-HBED-CC ([Al18F]PSMA-11) for nuclear medicine applications. Lysine 86-89 folate hydrolase 1 Homo sapiens 111-115 29520394-2 2017 [68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer. Lysine 24-27 folate hydrolase 1 Homo sapiens 49-53 29520394-2 2017 [68Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer. Lysine 24-27 folate hydrolase 1 Homo sapiens 74-78 27248781-6 2016 The PSMA-mediated internalization of (68)Ga-labeled NO3A-DM1-Lys-Urea-Glu displayed a time-dependent manner, allowing the desired drug delivery and release within tumor cells. Lysine 61-64 folate hydrolase 1 Homo sapiens 4-8 27248781-8 2016 Small animal PET imaging with (68)Ga-labeled NO3A-DM1-Lys-Urea-Glu exhibited significantly higher uptake (p < 0.01) in the PSMA positive PC3-PIP tumors (4.30 +- 0.20%ID/g) at 1 h postinjection than in the PSMA negative PC3-Flu tumors (1.12 +- 0.42%ID/g). Lysine 54-57 folate hydrolase 1 Homo sapiens 126-130 27248781-8 2016 Small animal PET imaging with (68)Ga-labeled NO3A-DM1-Lys-Urea-Glu exhibited significantly higher uptake (p < 0.01) in the PSMA positive PC3-PIP tumors (4.30 +- 0.20%ID/g) at 1 h postinjection than in the PSMA negative PC3-Flu tumors (1.12 +- 0.42%ID/g). Lysine 54-57 folate hydrolase 1 Homo sapiens 208-212 26404016-3 2016 This report analyses the potential of [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning. Lysine 55-58 folate hydrolase 1 Homo sapiens 80-84 26404016-3 2016 This report analyses the potential of [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning. Lysine 55-58 folate hydrolase 1 Homo sapiens 148-182 26404016-3 2016 This report analyses the potential of [(68)Ga]Glu-urea-Lys(Ahx)-HBED-CC ((68)Ga-PSMA-11), a new positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA) for prostate cancer staging and individualized radiotherapy planning. Lysine 55-58 folate hydrolase 1 Homo sapiens 184-188 25518963-4 2014 By coupling the specific binding motif glutamate-urea-lysine with the chelator HBED-CC, which complexes Ga-68 very effectively, a new radiopharmaceutical is available for Ga-68-PSMA-PET/CT. Lysine 54-60 folate hydrolase 1 Homo sapiens 177-181 24464532-4 2014 METHODS: The nonapeptide BZH3 representing the GRPR binding part was combined with the urea-based PSMA inhibitor Glu-urea-Lys(Ahx)-HBED-CC. Lysine 122-125 folate hydrolase 1 Homo sapiens 98-102 18637669-8 2008 PSMA can accommodate the steric requirements of (99m)Tc/Re complexes within PSMA inhibitors, the best results achieved with a linker moiety between the epsilon amine of the urea lysine and the chelator. Lysine 178-184 folate hydrolase 1 Homo sapiens 0-4 18637669-8 2008 PSMA can accommodate the steric requirements of (99m)Tc/Re complexes within PSMA inhibitors, the best results achieved with a linker moiety between the epsilon amine of the urea lysine and the chelator. Lysine 178-184 folate hydrolase 1 Homo sapiens 76-80 26162799-0 2015 PSMA PET/CT with Glu-urea-Lys-(Ahx)-[68Ga(HBED-CC)] versus 3D CT volumetric lymph node assessment in recurrent prostate cancer. Lysine 26-29 folate hydrolase 1 Homo sapiens 0-4 26162799-2 2015 The purpose of this retrospective investigation was to evaluate the volume and dimensions of nodes identified by Glu-urea-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA-11) in the setting of recurrent prostate cancer. Lysine 122-125 folate hydrolase 1 Homo sapiens 158-162 24939622-8 2014 In addition, immunoprecipitation analysis revealed that VPA increased the acetylation of GCPII protein at the lysine residues and facilitated a decrease of the poly-ubiquitinated GCPII level. Lysine 110-116 folate hydrolase 1 Homo sapiens 89-94 24939622-11 2014 Taken together, this study demonstrated that the increase in GCPII induced by VPA is not due to the classical epigenetic mechanism, but via enhanced acetylation of lysine residues in GCPII. Lysine 164-170 folate hydrolase 1 Homo sapiens 61-66 24939622-11 2014 Taken together, this study demonstrated that the increase in GCPII induced by VPA is not due to the classical epigenetic mechanism, but via enhanced acetylation of lysine residues in GCPII. Lysine 164-170 folate hydrolase 1 Homo sapiens 183-188 24983957-2 2014 68Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) represents a successful novel PSMA inhibitor radiotracer which has recently demonstrated its suitability in individual first-in-man studies. Lysine 23-26 folate hydrolase 1 Homo sapiens 50-54 24983957-2 2014 68Ga-labelled Glu-urea-Lys(Ahx)-HBED-CC ([68Ga]Ga-PSMA-HBED-CC) represents a successful novel PSMA inhibitor radiotracer which has recently demonstrated its suitability in individual first-in-man studies. Lysine 23-26 folate hydrolase 1 Homo sapiens 94-98 24983957-4 2014 The simple replacement of HBED-CC by the prominent radiometal chelator DOTA was shown to dramatically reduce the in vivo imaging quality of the respective 68Ga-labelled PSMA-targeted tracer proving that HBED-CC contributes intrinsically to the PSMA binding of the Glu-urea-Lys(Ahx) pharmacophore. Lysine 273-276 folate hydrolase 1 Homo sapiens 169-173 24508213-3 2014 METHODS: The PSMA/GRPr dual targeting ligand precursor [DUPA-6-Ahx-K-5-Ava-BBN(7-14)NH2], was synthesized by solid-phase and manual peptide synthesis, after which NODAGA was added via manual conjugation to the epsilon-amine of lysine (K). Lysine 227-233 folate hydrolase 1 Homo sapiens 13-17 23733925-3 2013 METHODS: Four PSMA inhibitors derived from the glutamate-urea-glutamate or glutamate-urea-lysine pharmacophores conjugated to CIM or TIM chelators were radiolabeled with (99m)Tc and evaluated in vitro and in vivo. Lysine 90-96 folate hydrolase 1 Homo sapiens 14-18 23256224-13 2004 [(111)In]3 is a bivalent compound that was synthesized by incorporating a PSMA-binding Lys-Glu urea motif for exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety (8). Lysine 87-90 folate hydrolase 1 Homo sapiens 74-78 23256225-13 2004 [(111)In]3 is a bivalent compound that was synthesized by incorporating a PSMA-binding Lys-Glu urea motif for exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety (1). Lysine 87-90 folate hydrolase 1 Homo sapiens 74-78 22207391-2 2011 Our system contains a lysine-based (micro-, e-) dialkyne residue for incorporating a PSMA binding Lys-Glu urea motif exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety. Lysine 22-28 folate hydrolase 1 Homo sapiens 85-89 22207391-2 2011 Our system contains a lysine-based (micro-, e-) dialkyne residue for incorporating a PSMA binding Lys-Glu urea motif exploiting click chemistry and a second lysine residue for subsequent modification with an imaging or therapeutic moiety. Lysine 98-101 folate hydrolase 1 Homo sapiens 85-89