PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17303175-0	2007	Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.	Dronabinol	54-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
23987522-2	2013	Cytochrome-P450-mediated metabolism of each leads to the generation of pharmacologically active (omega)- and (omega-1)-monohydroxyl metabolites that retain high affinity for cannabinoid type-1 receptors, exhibit Delta(9)-THC-like effects in rodents, and are conjugated with glucuronic acid prior to excretion in human urine.	Dronabinol	212-224	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
35115300-1	2022	We previously reported the unbound reversible (IC50,u) and time-dependent (KI,u) inhibition potencies of cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and THC metabolites (11-OH THC, 11-COOH THC) against the major cytochrome P450 (CYP) enzymes (1A2, 2C9, 2C19, 2D6, 3A).	Dronabinol	164-167	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	223-238	
34493602-8	2021	These data suggest that cannabinoids and major THC metabolites are able to inhibit the activities of multiple CYP enzymes, and basic static modelling of these data suggest the possibility of pharmacokinetic interactions between these cannabinoids and xenobiotics extensively metabolized by CYP2B6, CYP2C9 and CYP2D6.	Dronabinol	47-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	110-113	
35115300-1	2022	We previously reported the unbound reversible (IC50,u) and time-dependent (KI,u) inhibition potencies of cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and THC metabolites (11-OH THC, 11-COOH THC) against the major cytochrome P450 (CYP) enzymes (1A2, 2C9, 2C19, 2D6, 3A).	Dronabinol	124-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	223-238	
35115300-1	2022	We previously reported the unbound reversible (IC50,u) and time-dependent (KI,u) inhibition potencies of cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and THC metabolites (11-OH THC, 11-COOH THC) against the major cytochrome P450 (CYP) enzymes (1A2, 2C9, 2C19, 2D6, 3A).	Dronabinol	124-152	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	240-243	
35115300-1	2022	We previously reported the unbound reversible (IC50,u) and time-dependent (KI,u) inhibition potencies of cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and THC metabolites (11-OH THC, 11-COOH THC) against the major cytochrome P450 (CYP) enzymes (1A2, 2C9, 2C19, 2D6, 3A).	Dronabinol	154-157	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	223-238	
35115300-1	2022	We previously reported the unbound reversible (IC50,u) and time-dependent (KI,u) inhibition potencies of cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and THC metabolites (11-OH THC, 11-COOH THC) against the major cytochrome P450 (CYP) enzymes (1A2, 2C9, 2C19, 2D6, 3A).	Dronabinol	154-157	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	240-243	
35115300-1	2022	We previously reported the unbound reversible (IC50,u) and time-dependent (KI,u) inhibition potencies of cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and THC metabolites (11-OH THC, 11-COOH THC) against the major cytochrome P450 (CYP) enzymes (1A2, 2C9, 2C19, 2D6, 3A).	Dronabinol	164-167	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	240-243	
35115300-10	2022	Significance Statement This study, combined with our previous findings, provides for the first time a comprehensive analysis of the potential for cannabidiol, delta-9-tetrahydrocannabinol, and their metabolites to inhibit cytochrome P450 enzymes in a reversible or time-dependent manner.	Dronabinol	159-187	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	222-237	
24160757-4	2014	CYP-450 enzymes may also contribute to the secondary metabolism of THC, and UDP-glucuronosyltransferases have been identified as capable of catalyzing both primary (CBD, CBN) and secondary (THC, JWH-018, JWH-073) cannabinoid metabolism.	Dronabinol	67-70	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-7	
116333-1	1979	Delta 9-THC and 11-OH-delta 9-THC appear to in vivo affect the metabolism of both Type I and Type II substrates involving cytochrome P-450 as well as to affect the metabolism of a substrate requiring cytochrome P-448.	Dronabinol	0-11	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	122-138	
24160757-4	2014	CYP-450 enzymes may also contribute to the secondary metabolism of THC, and UDP-glucuronosyltransferases have been identified as capable of catalyzing both primary (CBD, CBN) and secondary (THC, JWH-018, JWH-073) cannabinoid metabolism.	Dronabinol	190-193	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-7