PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14996418-2 2004 THC"s impact on peritoneal macrophages to deliver costimulatory signals to a helper T cell hybridoma was investigated by T cell interleukin-2 production stimulated with immobilized anti-CD3 antibody. Dronabinol 0-3 interleukin 2 Mus musculus 128-141 9916880-3 1998 After 7 days of treatment, when mice were tolerant to delta9-THC-induced analgesia, these functional parameters were strongly inhibited and there was a persistent reduction in IL-2 and IFNgamma. Dronabinol 61-64 interleukin 2 Mus musculus 176-180 11809870-7 2002 Enhancement of IL-2 was also demonstrated with CP55940, Delta(9)-tetrahydrocannabinol, and cannabidiol, thus suggesting that the phenomenon is not unique to CBN. Dronabinol 56-85 interleukin 2 Mus musculus 15-19 12668119-6 2003 Cannabinol (CBN) or Delta(9)-tetrahydrocannabinol (Delta(9)-THC; 50 mg/kg, ip), administered daily for 3 consecutive days before sensitization and then before challenge, significantly attenuated the elevation of IL-2, IL-4, IL-5, and IL-13 steady-state mRNA expression elicited by Ova challenge in the lungs. Dronabinol 20-49 interleukin 2 Mus musculus 212-216 12668119-6 2003 Cannabinol (CBN) or Delta(9)-tetrahydrocannabinol (Delta(9)-THC; 50 mg/kg, ip), administered daily for 3 consecutive days before sensitization and then before challenge, significantly attenuated the elevation of IL-2, IL-4, IL-5, and IL-13 steady-state mRNA expression elicited by Ova challenge in the lungs. Dronabinol 51-63 interleukin 2 Mus musculus 212-216 2844686-0 1988 Suppression by delta-9-tetrahydrocannabinol of interleukin 2-induced lymphocyte proliferation and lymphokine-activated killer cell activity. Dronabinol 15-43 interleukin 2 Mus musculus 47-60 8662742-5 1996 Treatment of EL4.IL-2 cells with either cannabinol or Delta9-THC disrupted the adenylate cyclase signaling cascade by inhibiting forskolin-stimulated cAMP accumulation which consequently led to a decrease in protein kinase A activity and the binding of transcription factors to a CRE consensus sequence. Dronabinol 54-64 interleukin 2 Mus musculus 17-21 8662742-6 1996 Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC. Dronabinol 213-223 interleukin 2 Mus musculus 83-96 8662742-6 1996 Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC. Dronabinol 213-223 interleukin 2 Mus musculus 98-102 8662742-6 1996 Likewise, an inhibition of phorbol 12-myristate 13-acetate (PMA)/ionomycin-induced interleukin 2 (IL-2) protein secretion, which correlated to decreased IL-2 gene transcription, was induced by both cannabinol and Delta9-THC. Dronabinol 213-223 interleukin 2 Mus musculus 153-157 8964654-6 1995 In contrast, the THC-induced enhancement appeared to be related in part to IL-2 levels in the adult cell cultures such that when IL-2 was removed, not only did up-regulation not occur, but THC was, in fact, suppressive. Dronabinol 17-20 interleukin 2 Mus musculus 75-79 8964654-6 1995 In contrast, the THC-induced enhancement appeared to be related in part to IL-2 levels in the adult cell cultures such that when IL-2 was removed, not only did up-regulation not occur, but THC was, in fact, suppressive. Dronabinol 17-20 interleukin 2 Mus musculus 129-133 8964654-7 1995 Addition of IL-2 or supernatants from adult cells did lead to a modified THC-induced up-regulation of proliferation in cells from adult or 2-week-old mice. Dronabinol 73-76 interleukin 2 Mus musculus 12-16 8964654-10 1995 These results demonstrate a difference in immune response to THC related to the age of the mice which correlates at least in part to IL-2 levels in 2-week-old and young adult mice. Dronabinol 61-64 interleukin 2 Mus musculus 133-137 7523319-1 1994 Delta-9-tetrahydrocannabinol (THC), the major psychoactive component in marijuana, has been shown to suppress a variety of interleukin-2-(IL-2)-dependent cellular functions in both murine and human lymphocytes. Dronabinol 0-28 interleukin 2 Mus musculus 123-136 7523319-1 1994 Delta-9-tetrahydrocannabinol (THC), the major psychoactive component in marijuana, has been shown to suppress a variety of interleukin-2-(IL-2)-dependent cellular functions in both murine and human lymphocytes. Dronabinol 30-33 interleukin 2 Mus musculus 123-136 7523319-4 1994 Interleukin-2-induced protein synthesis was also suppressed in a dose related manner over this THC concentration range, with the hPBL being more susceptible to the suppressive effect of THC than the CTLL-2 cells. Dronabinol 95-98 interleukin 2 Mus musculus 0-13 7523319-4 1994 Interleukin-2-induced protein synthesis was also suppressed in a dose related manner over this THC concentration range, with the hPBL being more susceptible to the suppressive effect of THC than the CTLL-2 cells. Dronabinol 186-189 interleukin 2 Mus musculus 0-13 1649242-2 1991 We report here that the interleukin-2 (IL-2)-dependent murine cell line, NKB61A2, which we recently found to express both NK and NC functions, can be modulated selectively by 9 delta-tetrahydrocannabinol (THC). Dronabinol 205-208 interleukin 2 Mus musculus 24-37 1649242-2 1991 We report here that the interleukin-2 (IL-2)-dependent murine cell line, NKB61A2, which we recently found to express both NK and NC functions, can be modulated selectively by 9 delta-tetrahydrocannabinol (THC). Dronabinol 205-208 interleukin 2 Mus musculus 39-43 8380215-0 1993 Contrasting effect of delta-9-tetrahydrocannabinol on IL-2 activity in spleen and lymph node cells of mice of different ages. Dronabinol 22-50 interleukin 2 Mus musculus 54-58 8380215-9 1993 The THC modulating activity is directly related to its effect on both IL-2 activity and generation of Tac positive cells in spleen and lymph node cells of both adult and young mice. Dronabinol 4-7 interleukin 2 Mus musculus 70-74 2449494-2 1988 We evaluated the processing requirement of this compact peptide by accessory cells for presentation to apamin-reactive T hybridoma cells (THC) by analyzing the IL-2 responses of 16 THC from apamin-primed BALB/c or C57BL/6 mice, to various forms of either native or chemically synthesized apamin analogs. Dronabinol 138-141 interleukin 2 Mus musculus 160-164 2844686-3 1988 In addition, spleen cells previously stimulated in culture with IL-2 and then incubated with THC for 4 h prior to target cell addition, displayed suppressed cytolytic activity against both YAC-1 and EL-4 tumor targets. Dronabinol 93-96 interleukin 2 Mus musculus 64-68 2844686-5 1988 These results suggest that THC can suppress several important functions of IL-2 including clonal expansion of lymphocytes, expansion of killer cell populations and stimulation of killer cell cytotoxic activity. Dronabinol 27-30 interleukin 2 Mus musculus 75-79 18791168-4 2008 Likewise, similar control responses and sensitivity to Delta9-THC were observed in mixed lymphocyte responses (MLR) and in IL-2 and IFN-gamma production in both genotypes. Dronabinol 55-65 interleukin 2 Mus musculus 123-127 22899554-6 2012 THC or CBD suppressed or enhanced IFN-gamma and IL-2 production by mouse splenocytes under optimal or suboptimal stimulation, respectively. Dronabinol 0-3 interleukin 2 Mus musculus 48-52 26034207-6 2015 THC treatment significantly reduced T cell proliferation and activation in draining LNs of the recipient mice and decreased early stage rejection-indicator cytokines, including IL-2 and IFN-gamma. Dronabinol 0-3 interleukin 2 Mus musculus 177-181