PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18990727-0	2009	Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse.	allyl cyanide	0-12	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	27-33	
18990727-6	2009	Following allylnitrile exposure, mortality was lower in CYP2E1-null than in 129S1 mice, and increased after acetone pretreatment only in 129S1 mice.	allyl cyanide	10-22	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	56-62	
18990727-12	2009	We conclude that CYP2E1-mediated metabolism of allylnitrile leads to cyanide release and acute mortality, probably through alpha-carbon hydroxylation, and hypothesize that epoxidation of the beta-gamma double bond by CYP2A5 mediates vestibular toxicity.	allyl cyanide	47-59	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	17-23	
18990727-1	2009	This study addressed the hypothesis that the vestibular or lethal toxicities of allylnitrile depend on CYP2E1-mediated bioactivation.	allyl cyanide	80-92	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	103-109