PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19303321-3	2009	Indeed, the migration of human neutrophils towards IL-8 was significantly inhibited by the P2Y receptor antagonists, suramin and reactive blue 2 (RB-2) and potentiated by a P2Y(2) ligand, ATP, but insensitive to specific antagonists of P2Y(1), P2Y(6) and P2Y(11) receptors.	Suramin	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	51-55	
25816245-8	2015	The non-selective P2 receptor antagonists, suramin and pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid) tetrasodium salt hydrate (PPADS), significantly blocked the HNP-1-induced expression of IL-8 in the Caco-2 cells.	Suramin	43-50	C-X-C motif chemokine ligand 8	Homo sapiens	199-203	
16750994-8	2006	The purinergic receptor antagonist suramin did block LL-37-induced ERK1/2 phosphorylation and IL-8 release, and expression of mRNA for the purinergic receptor P2X(7) was detected in HASM cells.	Suramin	35-42	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
16322472-5	2006	HNP-induced IL-8 release was inhibited by treatment with the nucleotide receptor antagonists suramin and reactive blue.	Suramin	93-100	C-X-C motif chemokine ligand 8	Homo sapiens	12-16	
34372688-10	2021	IL-1beta-induced inflammation, assessed by IL-1beta, IL-8, and tumour necrosis factor alpha (TNF-alpha) upregulation, was alleviated by suramin treatment.	Suramin	136-143	C-X-C motif chemokine ligand 8	Homo sapiens	53-57	
25816245-10	2015	In agreement with this finding, HNP-1 also significantly increased IL-8 production in the P2Y6-negative human colon cancer cell line, HT-29, and this increase was blocked by treatment with suramin and PPADS.	Suramin	189-196	C-X-C motif chemokine ligand 8	Homo sapiens	67-71	
20722064-6	2011	RESULTS: ATP-enhanced IL-8 production was only partly blocked by the P(2) receptor antagonist suramin and required activation of NF-kappaB while ATP-mediated reduction of CCL20 was completely blocked by suramin and required activation of ERK1/2.	Suramin	94-101	C-X-C motif chemokine ligand 8	Homo sapiens	22-26	
25445541-4	2015	The LPS-induced release of these cytokines was also modulated by purinergic receptor activation since IL-8 and MCP-1 release was decreased by the nucleotide scavenger apyrase as well as by the pharmacological P2Y6 receptor antagonists suramin and MRS2578.	Suramin	235-242	C-X-C motif chemokine ligand 8	Homo sapiens	102-106	
19654006-9	2009	Treatment of neutrophils with apyrase (catalyses the hydrolysis of ATP to yield AMP) and suramin (P2-receptor antagonist) abrogated the release of CXCL8 and elastase induced by cigarette smoke extract and exogenous ATP.	Suramin	89-96	C-X-C motif chemokine ligand 8	Homo sapiens	147-152	
19735076-6	2009	In addition, IL-8 secretion was markedly diminished by the non-selective P2 receptor antagonists reactive blue 2 and suramin, and by a selective P2Y(6) antagonist, MRS2578.	Suramin	117-124	C-X-C motif chemokine ligand 8	Homo sapiens	13-17