PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30510002-7	2018	We suggest that persistent Sae2 binding at DSBs in the mre11-nd mutant counteracts the inhibitory effects of Rad9 and Rad53 on Exo1 and Dna2-Sgs1-mediated resection, accounting for the different phenotypes conferred by mre11-nd and sae2Delta mutations.	dsbs	43-47	checkpoint kinase 2	Homo sapiens	118-123	
15361830-4	2004	The full activation of Chk2 kinase, however, is triggered by treatments inflicting >19 DSBs per cell (e.g. 1 Gy), which cause Chk2 autophosphorylation on Thr387, Chk2-dependent accumulation of p21waf1 and checkpoint arrest in the S phase.	dsbs	90-94	checkpoint kinase 2	Homo sapiens	23-27	
24912678-3	2014	We show that in camptothecin-treated cells, DSBs induce RhoB expression by a mechanism that depends notably on Chk2 and its substrate HuR, which binds to RhoB mRNA and protects it against degradation.	dsbs	44-48	checkpoint kinase 2	Homo sapiens	111-115	
24912678-6	2014	Thus, we propose that DSBs activate a Chk2-HuR-RhoB pathway that promotes PP2A-mediated dephosphorylation of gammaH2AX and DSB repair.	dsbs	22-26	checkpoint kinase 2	Homo sapiens	38-42	
24464432-2	2014	In response to DSBs, the ATM kinase is activated and subsequently phosphorylates numerous downstream substrates, including p53, Chk2, BRCA1, and KAP1, which affect processes such as cell cycle progression and DNA repair.	dsbs	15-19	checkpoint kinase 2	Homo sapiens	128-132	
19375317-4	2009	In response to radiation-induced DSBs, but not chromatin-remodelling agents, the telomeric Chk2-TRF2 binding dissociates in a Chk2 activity-dependent manner.	dsbs	33-37	checkpoint kinase 2	Homo sapiens	91-95	
19375317-4	2009	In response to radiation-induced DSBs, but not chromatin-remodelling agents, the telomeric Chk2-TRF2 binding dissociates in a Chk2 activity-dependent manner.	dsbs	33-37	checkpoint kinase 2	Homo sapiens	126-130	
15361830-4	2004	The full activation of Chk2 kinase, however, is triggered by treatments inflicting >19 DSBs per cell (e.g. 1 Gy), which cause Chk2 autophosphorylation on Thr387, Chk2-dependent accumulation of p21waf1 and checkpoint arrest in the S phase.	dsbs	90-94	checkpoint kinase 2	Homo sapiens	129-133	
21263216-4	2011	BrdU photolysis resulted in well-controlled, dose- dependent generation of DSBs equivalent to radiation doses between 0.2 - 20 Gy, as determined by pulsed-field gel electrophoresis, and accompanied by dose-dependent ATM (ser-1981), H2AX (ser-139), Chk2 (thr-68), and p53 (ser-15) phosphorylation.	dsbs	75-79	checkpoint kinase 2	Homo sapiens	248-252	
15361830-4	2004	The full activation of Chk2 kinase, however, is triggered by treatments inflicting >19 DSBs per cell (e.g. 1 Gy), which cause Chk2 autophosphorylation on Thr387, Chk2-dependent accumulation of p21waf1 and checkpoint arrest in the S phase.	dsbs	90-94	checkpoint kinase 2	Homo sapiens	129-133	
11533665-3	2001	Here we show that this complex is required for phosphorylation and activation of the Rad53 and Chk1 checkpoint kinases specifically in response to DSBs.	dsbs	147-151	checkpoint kinase 2	Homo sapiens	85-90	
35474765-7	2022	ROS-induced DNA DSBs get repaired in HCT116 cells, in which CHEK2 is in the normal functional state, but these DNA DSBs persist in CHEK2-null HCT116 cells as confirmed by the immunofluorescence analysis of 53BP1 and gamma-H2AX.	dsbs	16-20	checkpoint kinase 2	Homo sapiens	60-65