PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Glutamic Acid	28-37	pyrroline-5-carboxylate reductase 1	Homo sapiens	59-67	
34769188-3	2021	One of the important mediators in energy production and interconversion of carbons in the cell is Delta1-pyrroline-5-carboxylate (P5C)-the physiological intracellular intermediate of the interconversion of proline, ornithine, and glutamate.	Glutamic Acid	230-239	pyrroline-5-carboxylate reductase 1	Homo sapiens	104-128	
34769188-3	2021	One of the important mediators in energy production and interconversion of carbons in the cell is Delta1-pyrroline-5-carboxylate (P5C)-the physiological intracellular intermediate of the interconversion of proline, ornithine, and glutamate.	Glutamic Acid	230-239	pyrroline-5-carboxylate reductase 1	Homo sapiens	130-133	
34769188-6	2021	P5C is produced by P5C synthase (P5CS) from glutamate, and ornithine via ornithine delta-amino acid transferase (deltaOAT).	Glutamic Acid	44-53	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-3	
34769188-12	2021	This review focuses on the metabolism of P5C in the cell as an interconversion mediator of proline, glutamate, and ornithine and its role in the regulation of survival and death with particular emphasis on the metabolic context.	Glutamic Acid	100-109	pyrroline-5-carboxylate reductase 1	Homo sapiens	41-44	
33830435-3	2021	One of three Pyrroline-5-carboxylate reductases (PYCR), is primarily involved in conversion of glutamate to proline.	Glutamic Acid	95-104	pyrroline-5-carboxylate reductase 1	Homo sapiens	49-53	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Glutamic Acid	28-37	pyrroline-5-carboxylate reductase 1	Homo sapiens	64-67	
29648801-3	2018	Proline is synthesized from glutamate or ornithine through GSAL/P5C, which is reduced to proline by P5C reductase (PYCR) in a NAD(P)H-dependent reaction.	Glutamic Acid	28-37	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-119	
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Glutamic Acid	196-209	pyrroline-5-carboxylate reductase 1	Homo sapiens	53-56	
23024808-3	2012	Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs).	Glutamic Acid	35-44	pyrroline-5-carboxylate reductase 1	Homo sapiens	106-109	
23024808-5	2012	Based on these studies we conclude that PYCR1 and PYCR2, which are localized in the mitochondria, are primarily involved in conversion of glutamate to proline.	Glutamic Acid	138-147	pyrroline-5-carboxylate reductase 1	Homo sapiens	40-45	
28255779-9	2017	Electron microscopy of patient fibroblasts demonstrated widespread vacuolation containing neutral and phospho-lipids as demonstrated by Oil Red O and Sudan Black tinctorial staining; this might be explained by impaired activity of the proline/pyrroline-5-carboxylate (P5C) shuttle if SLC25A22 transports pyrroline-5-carboxylate/glutamate-gamma-semialdehyde as well as glutamate.	Glutamic Acid	328-337	pyrroline-5-carboxylate reductase 1	Homo sapiens	235-266	
22615405-3	2012	Less well-recognized, glutamate can also be converted to proline through Delta(1)-pyrroline-5-carboxylate (P5C) and vice versa.	Glutamic Acid	22-31	pyrroline-5-carboxylate reductase 1	Homo sapiens	73-105	
18806120-1	2008	The cellular metabolism of glutamine and proline are closely interrelated, because they can be interconverted with glutamate and ornithine via the mitochondrial pathway involving pyrroline-5-carboxylate (P5C).	Glutamic Acid	115-124	pyrroline-5-carboxylate reductase 1	Homo sapiens	204-207	
20641645-0	2004	(99m)Tc-Acetyl-Asn-Gln-Glu-Gln-Val-Ser-Pro-3-iodo-Tyr-Thr-Leu-Leu-Lys-Gly-NC100194 Thrombosis plays a major role in many cardiovascular diseases such as myocardial infarction, pulmonary embolism, deep venous thrombosis, or cerebral venous thrombosis (1).	Glutamic Acid	23-26	pyrroline-5-carboxylate reductase 1	Homo sapiens	39-44	
20641645-5	2004	NC100668 (Acetyl-Asn-Gln-Glu-Gln-Val-Ser-Pro-3-iodo-Tyr-Thr-Leu-Leu-Lys-Gly-NC100194) is a probe that is recognized by the enzyme FXIIIa and covalently binds to fibrin by means of the transglutamase activity of FXIIIa (4, 5).	Glutamic Acid	25-28	pyrroline-5-carboxylate reductase 1	Homo sapiens	41-46	
23105736-1	2008	Currently available method(s) for assaying pyrroline-5-carboxylate (P5C), an important intermediate metabolite of ornithine, proline and glutamate metabolic pathways, are cumbersome or not sensitive enough for microanalysis.	Glutamic Acid	137-146	pyrroline-5-carboxylate reductase 1	Homo sapiens	68-71