PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20876609-3 2010 Recently D-serine, one of the substrates of DAO, has been found in the mammalian brain, and shown to be a co-agonist of the N-methyl-D-aspartate (NMDA) receptor in glutamate neurotransmission. Glutamic Acid 164-173 D-amino acid oxidase Homo sapiens 44-47 23555897-12 2013 CONCLUSIONS: These results suggest that DAO, which is involved in the N-methyl-d-aspartate receptor regulation, signaling and glutamate metabolism, is the master gene of the genetic associations and interactions underlying schizophrenia. Glutamic Acid 126-135 D-amino acid oxidase Homo sapiens 40-43 23555897-13 2013 Besides, the interaction between DAO and RASD2 has provided an insight in integrating the glutamate and dopamine hypotheses of schizophrenia. Glutamic Acid 90-99 D-amino acid oxidase Homo sapiens 33-36 21956578-2 2012 D-aspartate oxidase is specific for acidic D-amino acids (i.e., D-aspartate and D-glutamate) and D-amino acid oxidase is active on neutral and polar D-amino acids (a low activity is also detected on basic D-amino acids). Glutamic Acid 80-91 D-amino acid oxidase Homo sapiens 97-117 30165950-0 2018 D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia? Glutamic Acid 39-48 D-amino acid oxidase Homo sapiens 0-20 19077230-3 2008 Initial reports suggested G72 as an activator of D-amino acid oxidase (DAO), supporting the glutamate dysfunction hypothesis of schizophrenia. Glutamic Acid 92-101 D-amino acid oxidase Homo sapiens 71-74 17250995-0 2007 Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia. Glutamic Acid 48-57 D-amino acid oxidase Homo sapiens 40-44 17250995-1 2007 We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia. Glutamic Acid 64-73 D-amino acid oxidase Homo sapiens 56-60 2570065-1 1989 In order to evaluate the possible contributions of Lys-204, Tyr-224, Tyr-228, and His-307 in porcine kidney D-amino acid oxidase [EC 1.4.3.3] (DAO) to its catalytic function, we constructed four point mutant cDNAs encoding enzymes possessing Glu-204, Phe-224, Phe-228, and Leu-307 by oligonucleotide-directed in vitro mutagenesis. Glutamic Acid 242-245 D-amino acid oxidase Homo sapiens 143-146 2570065-4 1989 The Glu-204 and Phe-224 mutant DAOs showed comparable enzyme activities to that of the wild type enzyme, and were inhibited strongly by sodium benzoate, a potent competitive inhibitor of DAO. Glutamic Acid 4-7 D-amino acid oxidase Homo sapiens 31-34 15672444-5 2005 Glutamate was detected in Schwann cell-conditioned medium at a concentration on the order of 10(-5) M. D-Amino acid oxidase (DAAOx) also attenuated the neurotoxicity exhibited by Schwann cells. Glutamic Acid 0-9 D-amino acid oxidase Homo sapiens 103-123 15672444-5 2005 Glutamate was detected in Schwann cell-conditioned medium at a concentration on the order of 10(-5) M. D-Amino acid oxidase (DAAOx) also attenuated the neurotoxicity exhibited by Schwann cells. Glutamic Acid 0-9 D-amino acid oxidase Homo sapiens 125-130 31799256-3 2019 By substituting Arg120 in hDAAO with a glutamate (to mimic the active NTS) or a leucine (to eliminate the positive charge) the protein conformation, thermal stability, and kinetic properties are slightly altered, while the dimeric structure and the ligand-binding properties are unchanged. Glutamic Acid 39-48 D-amino acid oxidase Homo sapiens 26-31 29114206-2 2017 The glutamate hypothesis of schizophrenia has proposed that increased DAO activity leads to decreased D-serine, which subsequently may lead to N-methyl-D-aspartate (NMDA) receptor hypofunction. Glutamic Acid 4-13 D-amino acid oxidase Homo sapiens 70-73 28864885-1 2018 The glutamate hypothesis of schizophrenia is related to the proposed dysregulation of D-amino acid oxidase (DAO), DAO activator (DAOA)/G72, and Neuregulin 1 (NRG1) genes. Glutamic Acid 4-13 D-amino acid oxidase Homo sapiens 86-106 28864885-1 2018 The glutamate hypothesis of schizophrenia is related to the proposed dysregulation of D-amino acid oxidase (DAO), DAO activator (DAOA)/G72, and Neuregulin 1 (NRG1) genes. Glutamic Acid 4-13 D-amino acid oxidase Homo sapiens 108-111 29093468-10 2017 DAO levels were significantly associated with D-glutamate and D-serine levels. Glutamic Acid 46-57 D-amino acid oxidase Homo sapiens 0-3 28477547-1 2017 G72 is a modulator of D-amino acid oxidase, the enzyme that degrades D-serine, an amino acid that plays a critical role in glutamate neurotransmission, and has been implicated in psychiatric disorders. Glutamic Acid 123-132 D-amino acid oxidase Homo sapiens 22-42