PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21956578-2	2012	D-aspartate oxidase is specific for acidic D-amino acids (i.e., D-aspartate and D-glutamate) and D-amino acid oxidase is active on neutral and polar D-amino acids (a low activity is also detected on basic D-amino acids).	Glutamic Acid	80-91	D-amino acid oxidase	Homo sapiens	97-117	
23555897-12	2013	CONCLUSIONS: These results suggest that DAO, which is involved in the N-methyl-d-aspartate receptor regulation, signaling and glutamate metabolism, is the master gene of the genetic associations and interactions underlying schizophrenia.	Glutamic Acid	126-135	D-amino acid oxidase	Homo sapiens	40-43	
23555897-13	2013	Besides, the interaction between DAO and RASD2 has provided an insight in integrating the glutamate and dopamine hypotheses of schizophrenia.	Glutamic Acid	90-99	D-amino acid oxidase	Homo sapiens	33-36	
20876609-3	2010	Recently D-serine, one of the substrates of DAO, has been found in the mammalian brain, and shown to be a co-agonist of the N-methyl-D-aspartate (NMDA) receptor in glutamate neurotransmission.	Glutamic Acid	164-173	D-amino acid oxidase	Homo sapiens	44-47	
15672444-5	2005	Glutamate was detected in Schwann cell-conditioned medium at a concentration on the order of 10(-5) M. D-Amino acid oxidase (DAAOx) also attenuated the neurotoxicity exhibited by Schwann cells.	Glutamic Acid	0-9	D-amino acid oxidase	Homo sapiens	103-123	
19077230-3	2008	Initial reports suggested G72 as an activator of D-amino acid oxidase (DAO), supporting the glutamate dysfunction hypothesis of schizophrenia.	Glutamic Acid	92-101	D-amino acid oxidase	Homo sapiens	71-74	
17250995-0	2007	Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia.	Glutamic Acid	48-57	D-amino acid oxidase	Homo sapiens	40-44	
17250995-1	2007	We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia.	Glutamic Acid	64-73	D-amino acid oxidase	Homo sapiens	56-60	
15672444-5	2005	Glutamate was detected in Schwann cell-conditioned medium at a concentration on the order of 10(-5) M. D-Amino acid oxidase (DAAOx) also attenuated the neurotoxicity exhibited by Schwann cells.	Glutamic Acid	0-9	D-amino acid oxidase	Homo sapiens	125-130	
31799256-3	2019	By substituting Arg120 in hDAAO with a glutamate (to mimic the active NTS) or a leucine (to eliminate the positive charge) the protein conformation, thermal stability, and kinetic properties are slightly altered, while the dimeric structure and the ligand-binding properties are unchanged.	Glutamic Acid	39-48	D-amino acid oxidase	Homo sapiens	26-31	
2570065-1	1989	In order to evaluate the possible contributions of Lys-204, Tyr-224, Tyr-228, and His-307 in porcine kidney D-amino acid oxidase [EC 1.4.3.3] (DAO) to its catalytic function, we constructed four point mutant cDNAs encoding enzymes possessing Glu-204, Phe-224, Phe-228, and Leu-307 by oligonucleotide-directed in vitro mutagenesis.	Glutamic Acid	242-245	D-amino acid oxidase	Homo sapiens	143-146	
2570065-4	1989	The Glu-204 and Phe-224 mutant DAOs showed comparable enzyme activities to that of the wild type enzyme, and were inhibited strongly by sodium benzoate, a potent competitive inhibitor of DAO.	Glutamic Acid	4-7	D-amino acid oxidase	Homo sapiens	31-34	
28864885-1	2018	The glutamate hypothesis of schizophrenia is related to the proposed dysregulation of D-amino acid oxidase (DAO), DAO activator (DAOA)/G72, and Neuregulin 1 (NRG1) genes.	Glutamic Acid	4-13	D-amino acid oxidase	Homo sapiens	86-106	
30165950-0	2018	D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia?	Glutamic Acid	39-48	D-amino acid oxidase	Homo sapiens	0-20	
28864885-1	2018	The glutamate hypothesis of schizophrenia is related to the proposed dysregulation of D-amino acid oxidase (DAO), DAO activator (DAOA)/G72, and Neuregulin 1 (NRG1) genes.	Glutamic Acid	4-13	D-amino acid oxidase	Homo sapiens	108-111	
28477547-1	2017	G72 is a modulator of D-amino acid oxidase, the enzyme that degrades D-serine, an amino acid that plays a critical role in glutamate neurotransmission, and has been implicated in psychiatric disorders.	Glutamic Acid	123-132	D-amino acid oxidase	Homo sapiens	22-42	
29114206-2	2017	The glutamate hypothesis of schizophrenia has proposed that increased DAO activity leads to decreased D-serine, which subsequently may lead to N-methyl-D-aspartate (NMDA) receptor hypofunction.	Glutamic Acid	4-13	D-amino acid oxidase	Homo sapiens	70-73	
29093468-10	2017	DAO levels were significantly associated with D-glutamate and D-serine levels.	Glutamic Acid	46-57	D-amino acid oxidase	Homo sapiens	0-3