PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14701853-3	2004	Because Klotho lacks the glutamic acid residues that have been shown to be involved in the catalytic activity of this family of enzymes, the function of this protein was unknown.	Glutamic Acid	25-38	klotho	Homo sapiens	8-14	
27125744-9	2016	We recently demonstrated that Klotho protects hippocampal neurons from amyloid and glutamate toxicity via the activation of an antioxidant enzymatic system suggesting Klotho is a neuroprotective protein.	Glutamic Acid	83-92	klotho	Homo sapiens	30-36	
29493420-3	2019	Here, we show that cultured hippocampal neurons respond to insulin and glutamate stimulation by elevating Klotho protein levels.	Glutamic Acid	71-80	klotho	Homo sapiens	106-112	
29978424-3	2019	Pretreatment of neurons with Klotho protein can avoid neuronal injury related to the toxic amyloid-beta and glutamate, centrally related to the pathogenesis of Alzheimer"s disease (AD), in order that Klotho protein could play a neuroprotective role in AD patients.	Glutamic Acid	108-117	klotho	Homo sapiens	29-35