PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34600073-6	2021	Moreover, the genetic and pharmacological downregulation of NLRP3 improved survival of RGCs against glutamate excitotoxicity.	Glutamic Acid	100-109	NLR family pyrin domain containing 3	Homo sapiens	60-65	
15050972-3	2004	A mitochondrial form, AII, has been thought to be more widely expressed and to be involved in the biosynthesis of polyamines, the amino acids ornithine, proline, and glutamate and in the inflammatory process, among others.	Glutamic Acid	166-175	NLR family pyrin domain containing 3	Homo sapiens	22-25	
34600073-7	2021	In the end, knockdown of Parkin exacerbated glutamate induced RGCs damage via triggering NLRP3 inflammasome activation.	Glutamic Acid	44-53	NLR family pyrin domain containing 3	Homo sapiens	89-94	
29663696-6	2018	In the work reported here, we examined the roles of the different beta-tubulin isotypes in response to glutamate/glycine treatment, and found that both betaII and betaIII bind to glutathione in the presence of ROS, especially betaIII.	Glutamic Acid	103-112	NLR family pyrin domain containing 3	Homo sapiens	152-170	
31129157-0	2019	KHG21834 attenuates glutamate-induced mitochondrial damage, apoptosis, and NLRP3 inflammasome activation in SH-SY5Y human neuroblastoma cells.	Glutamic Acid	20-29	NLR family pyrin domain containing 3	Homo sapiens	75-80	
31129157-6	2019	Furthermore, KHG21834 efficiently reduced glutamate-induced ER stress and NLRP3 inflammasome activation (59% and 65% of glutamate group, respectively).	Glutamic Acid	42-51	NLR family pyrin domain containing 3	Homo sapiens	74-79	
30459218-9	2019	Our results suggest that AII and A17 amacrines express clustered, extrasynaptic NMDA receptors, with different and complementary subunits that are likely to contribute differentially to signal processing and plasticity.SIGNIFICANCE STATEMENT Glutamate is the most important excitatory neurotransmitter in the CNS, but not all glutamate receptors transmit fast excitatory signals at synapses.	Glutamic Acid	242-251	NLR family pyrin domain containing 3	Homo sapiens	25-28	
35528000-0	2022	rs3806265 and rs4612666 of the NLRP3 Gene Are Associated With the Titer of Glutamic Acid Decarboxylase Antibody in Type 1 Diabetes.	Glutamic Acid	75-88	NLR family pyrin domain containing 3	Homo sapiens	31-36	
3583682-4	1987	A second isozyme, designated AII (or A4), has a neutral pI, is located in the mitochondrial matrix, and is thought to be involved primarily in the production of ornithine as a precursor of proline and glutamate.	Glutamic Acid	201-210	NLR family pyrin domain containing 3	Homo sapiens	29-32	
34048091-1	2021	The NMDA receptors (NMDARs) expressed by AII and A17 amacrine cells, the two main inhibitory interneurons of the rod pathway microcircuit in the mammalian retina, are exclusively extrasynaptic, activated by ambient levels of glutamate, and molecularly distinct, with AII and A17 amacrines expressing GluN2B- and GluN2A-containing receptors, respectively.	Glutamic Acid	225-234	NLR family pyrin domain containing 3	Homo sapiens	41-44	
34048091-1	2021	The NMDA receptors (NMDARs) expressed by AII and A17 amacrine cells, the two main inhibitory interneurons of the rod pathway microcircuit in the mammalian retina, are exclusively extrasynaptic, activated by ambient levels of glutamate, and molecularly distinct, with AII and A17 amacrines expressing GluN2B- and GluN2A-containing receptors, respectively.	Glutamic Acid	225-234	NLR family pyrin domain containing 3	Homo sapiens	267-270	
25791922-0	2015	Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK.	Glutamic Acid	20-29	NLR family pyrin domain containing 3	Homo sapiens	108-113	
25791922-3	2015	Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum stress (ER stress) and TXNIP/NLRP3 inflammasome activation, leading to damage in the hippocampus.	Glutamic Acid	0-9	NLR family pyrin domain containing 3	Homo sapiens	112-117	
25791922-10	2015	Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult.	Glutamic Acid	56-65	NLR family pyrin domain containing 3	Homo sapiens	121-126