PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34600073-6 2021 Moreover, the genetic and pharmacological downregulation of NLRP3 improved survival of RGCs against glutamate excitotoxicity. Glutamic Acid 100-109 NLR family pyrin domain containing 3 Homo sapiens 60-65 15050972-3 2004 A mitochondrial form, AII, has been thought to be more widely expressed and to be involved in the biosynthesis of polyamines, the amino acids ornithine, proline, and glutamate and in the inflammatory process, among others. Glutamic Acid 166-175 NLR family pyrin domain containing 3 Homo sapiens 22-25 34600073-7 2021 In the end, knockdown of Parkin exacerbated glutamate induced RGCs damage via triggering NLRP3 inflammasome activation. Glutamic Acid 44-53 NLR family pyrin domain containing 3 Homo sapiens 89-94 29663696-6 2018 In the work reported here, we examined the roles of the different beta-tubulin isotypes in response to glutamate/glycine treatment, and found that both betaII and betaIII bind to glutathione in the presence of ROS, especially betaIII. Glutamic Acid 103-112 NLR family pyrin domain containing 3 Homo sapiens 152-170 31129157-0 2019 KHG21834 attenuates glutamate-induced mitochondrial damage, apoptosis, and NLRP3 inflammasome activation in SH-SY5Y human neuroblastoma cells. Glutamic Acid 20-29 NLR family pyrin domain containing 3 Homo sapiens 75-80 31129157-6 2019 Furthermore, KHG21834 efficiently reduced glutamate-induced ER stress and NLRP3 inflammasome activation (59% and 65% of glutamate group, respectively). Glutamic Acid 42-51 NLR family pyrin domain containing 3 Homo sapiens 74-79 30459218-9 2019 Our results suggest that AII and A17 amacrines express clustered, extrasynaptic NMDA receptors, with different and complementary subunits that are likely to contribute differentially to signal processing and plasticity.SIGNIFICANCE STATEMENT Glutamate is the most important excitatory neurotransmitter in the CNS, but not all glutamate receptors transmit fast excitatory signals at synapses. Glutamic Acid 242-251 NLR family pyrin domain containing 3 Homo sapiens 25-28 35528000-0 2022 rs3806265 and rs4612666 of the NLRP3 Gene Are Associated With the Titer of Glutamic Acid Decarboxylase Antibody in Type 1 Diabetes. Glutamic Acid 75-88 NLR family pyrin domain containing 3 Homo sapiens 31-36 3583682-4 1987 A second isozyme, designated AII (or A4), has a neutral pI, is located in the mitochondrial matrix, and is thought to be involved primarily in the production of ornithine as a precursor of proline and glutamate. Glutamic Acid 201-210 NLR family pyrin domain containing 3 Homo sapiens 29-32 34048091-1 2021 The NMDA receptors (NMDARs) expressed by AII and A17 amacrine cells, the two main inhibitory interneurons of the rod pathway microcircuit in the mammalian retina, are exclusively extrasynaptic, activated by ambient levels of glutamate, and molecularly distinct, with AII and A17 amacrines expressing GluN2B- and GluN2A-containing receptors, respectively. Glutamic Acid 225-234 NLR family pyrin domain containing 3 Homo sapiens 41-44 34048091-1 2021 The NMDA receptors (NMDARs) expressed by AII and A17 amacrine cells, the two main inhibitory interneurons of the rod pathway microcircuit in the mammalian retina, are exclusively extrasynaptic, activated by ambient levels of glutamate, and molecularly distinct, with AII and A17 amacrines expressing GluN2B- and GluN2A-containing receptors, respectively. Glutamic Acid 225-234 NLR family pyrin domain containing 3 Homo sapiens 267-270 25791922-0 2015 Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Glutamic Acid 20-29 NLR family pyrin domain containing 3 Homo sapiens 108-113 25791922-3 2015 Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum stress (ER stress) and TXNIP/NLRP3 inflammasome activation, leading to damage in the hippocampus. Glutamic Acid 0-9 NLR family pyrin domain containing 3 Homo sapiens 112-117 25791922-10 2015 Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult. Glutamic Acid 56-65 NLR family pyrin domain containing 3 Homo sapiens 121-126