PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22643973-6	2012	We have identified three amino-terminal domains of Nef as necessary for secretion: (i) the four arginine residues (17,19,21, 22) comprising the basic region; (ii) the phosphofurin acidic cluster sequence (PACS) composed of four glutamic acid residues (61-64); (iii) a previously unknown motif spanning amino acid residues 65-69 (VGFPV) which we named the secretion modification region (SMR).	Glutamic Acid	228-241	S100 calcium binding protein B	Homo sapiens	51-54	
23399701-10	2013	In addition, for the first time, to our knowledge, these data indicate that S100B secretion can be modulated by nicotinic receptors, in addition to glutamate, dopamine and serotonin receptors.	Glutamic Acid	148-157	S100 calcium binding protein B	Homo sapiens	76-81	
22359053-0	2012	High-glucose and S100B stimulate glutamate uptake in C6 glioma cells.	Glutamic Acid	33-42	S100 calcium binding protein B	Homo sapiens	17-22	
22359053-6	2012	Moreover, glutamate uptake in C6 glioma cells, like primary astrocytes, was stimulated by extracellular S100B.	Glutamic Acid	10-19	S100 calcium binding protein B	Homo sapiens	104-109	
21886773-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Searching for possible TRAF binding sites on Nef, we found a TRAF2 consensus binding site in the AQEEEE sequence encompassing the conserved four-glutamate acidic cluster.	Glutamic Acid	177-186	S100 calcium binding protein B	Homo sapiens	77-80	
19853332-6	2010	RESULTS: S-100B in the glutamate group and the control group were 0.079+/-0.034microg/L and 0.090+/-0.042microg/L respectively (p=0.245).	Glutamic Acid	23-32	S100 calcium binding protein B	Homo sapiens	9-15	
28031466-7	2017	Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 alpha-sigma2 binding in a recent co-crystal structure, substantially reduced AP-2 interaction without affecting CD4 binding.	Glutamic Acid	40-43	S100 calcium binding protein B	Homo sapiens	15-18	
19469484-5	2009	The SBi279 binding site on Ca(2+)-S100B overlaps the SBi132 and SBi523 sites and contacts residues in both loop 2 (Ser-41, His-42, Phe-43, Leu-44, and Glu-45) and helix 4 (Ile-80, Ala-83, Cys-84, Phe-87, and Phe-88).	Glutamic Acid	151-154	S100 calcium binding protein B	Homo sapiens	34-39	
15491611-7	2004	Molecular modeling identified three residues in the core region of SF2 Nef (Ala83, His116, and Tyr120) which are substituted in ELI with Glu, Asn, and Ile, respectively.	Glutamic Acid	137-140	S100 calcium binding protein B	Homo sapiens	71-74	
16794859-0	2006	High glutamate decreases S100B secretion by a mechanism dependent on the glutamate transporter.	Glutamic Acid	5-14	S100 calcium binding protein B	Homo sapiens	25-30	
16794859-2	2006	Extracellular S100B protects hippocampal neurons from excitotoxic damage, whilst toxic levels of glutamate to neurons have been shown to reduce S100B secretion in astrocytes and brain slices, by an unknown mechanism.	Glutamic Acid	97-106	S100 calcium binding protein B	Homo sapiens	144-149	
16794859-4	2006	DCG-IV, an agonist of group II metabotropic glutamate receptors, caused a smaller decrease in S100B secretion when compared to 1 mM glutamate.	Glutamic Acid	44-53	S100 calcium binding protein B	Homo sapiens	94-99	
16794859-5	2006	D: -aspartate partially reverted the glutamate effect on S100B release and two other inhibitors, PDC and DIDS, reverted it completely.	Glutamic Acid	37-46	S100 calcium binding protein B	Homo sapiens	57-62	
16794859-6	2006	These findings suggest that S100B secretion is inversely coupled to glutamate uptake.	Glutamic Acid	68-77	S100 calcium binding protein B	Homo sapiens	28-33	
12486136-7	2003	The leucine residues of the EXXXLL motif found in Nef were required for binding to AP-1 and AP-3 in vitro and for the stabilization of these complexes on membranes in vivo, whereas the glutamic acid residue of this motif was required specifically for the binding and stabilization of AP-3.	Glutamic Acid	185-198	S100 calcium binding protein B	Homo sapiens	50-53	
34073816-6	2021	Intracellularly the S100B protein has a protective effect on neurons against the toxic effects of glutamate and stimulates neurites outgrowth and neuronal survival.	Glutamic Acid	98-107	S100 calcium binding protein B	Homo sapiens	20-25	
26382833-12	2015	In addition, varying amounts of S100B caused inhibition of glutamate uptake in astroglia in a dose-dependent manner.	Glutamic Acid	59-68	S100 calcium binding protein B	Homo sapiens	32-37	
26382833-14	2015	We speculate that S100B release by activated astroglia may have multiple roles in the pathophysiology of WNV neuro-invasive disease, including induction of neutrophil migration to the sites where blood brain barrier is disrupted as well as glutamate neurotoxicity.	Glutamic Acid	240-249	S100 calcium binding protein B	Homo sapiens	18-23	
25122770-5	2014	A new intercomplex contact was found between SH3 Glu-93, and Nef Arg-105.	Glutamic Acid	49-52	S100 calcium binding protein B	Homo sapiens	61-64	
25122770-6	2014	Mutagenesis of Hck SH3 Glu-93 interfered with Nef Hck complex formation and kinase activation in cells.	Glutamic Acid	23-26	S100 calcium binding protein B	Homo sapiens	46-49