PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21151552-3 2010 The cause for this disorder appears to be a mutation in the gene for the thrombopoeitin (TPO) receptor, c-Mpl, despite high levels of serum TPO. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 89-92 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 104-109 12623841-7 2003 Furthermore, TPO-stimulated cellular proliferation appears to be directly correlated with receptor internalization, indicating that internalization of the TPO/Mpl complex may be essential for normal signal transduction. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 13-16 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 159-162 12623841-8 2003 Finally, we have demonstrated that upon removal of TPO from the supernatant, Mpl promptly reappears on the cell surface, suggesting that a pool of intracellular Mpl can be rapidly recycled to the cell surface. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 51-54 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 77-80 12623841-8 2003 Finally, we have demonstrated that upon removal of TPO from the supernatant, Mpl promptly reappears on the cell surface, suggesting that a pool of intracellular Mpl can be rapidly recycled to the cell surface. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 51-54 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 161-164 12623841-9 2003 These data help identify the receptor motifs involved in TPO-induced internalization of Mpl and suggest that Mpl translocation may be necessary for normal cellular proliferation. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 57-60 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 88-91 12623841-9 2003 These data help identify the receptor motifs involved in TPO-induced internalization of Mpl and suggest that Mpl translocation may be necessary for normal cellular proliferation. (2,4,6-trimethylbenzoyl) diphenylphosphine oxide 57-60 MPL proto-oncogene, thrombopoietin receptor Homo sapiens 109-112