PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12743557-8	2003	Itraconazole reduced systemic immune activation, leading to a decrease in serum IgE levels (310 IU/mL) compared with levels seen in the placebo group (increase of 18 IU/mL, P <.01) and a decrease in IgG levels to A fumigatu s (15.4 IU/mL) compared with levels seen in the placebo group (increase of 3.7 IU/mL, P =.03).	Itraconazole	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	80-83	
10027433-1	1999	STUDY OBJECTIVES: (1) To determine the relationship between IgE levels and the prevalence of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) patients, (2) to establish the usefulness of assessing atopy as an identifying risk factor for ABPA, (3) to evaluate the clinical course of patients receiving and not receiving itraconazole as reflected in oral steroid dose requirements and number of acute episodes of ABPA, and (4) to determine the role of acute episodes of ABPA in pulmonary exacerbations of CF.	Itraconazole	341-353	immunoglobulin heavy constant epsilon	Homo sapiens	60-63	
23598928-3	2013	Additional therapy with itraconazole leads to the decrease of total IgE to the limits recommended for proper omalizumab dosing (30-1500 kUA/l).	Itraconazole	24-36	immunoglobulin heavy constant epsilon	Homo sapiens	68-71	
26549342-4	2015	Prednisolone 0.5 mg/kg/day and Itraconazole improved his symptoms and IgE levels.	Itraconazole	31-43	immunoglobulin heavy constant epsilon	Homo sapiens	70-73	
23598928-4	2013	Itraconazole, used as bridge therapy, provided us the opportunity to start anti-IgE treatment in a patient with high levels of total IgE, beyond the upper limits recommended for proper prescription of omalizumab.	Itraconazole	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	80-83	
23598928-4	2013	Itraconazole, used as bridge therapy, provided us the opportunity to start anti-IgE treatment in a patient with high levels of total IgE, beyond the upper limits recommended for proper prescription of omalizumab.	Itraconazole	0-12	immunoglobulin heavy constant epsilon	Homo sapiens	133-136	
21141064-6	2010	Following the administration of micafungin and itraconazole, the cavity lesion diminished in size, and his eosinophil and serum IgE levels decreased.	Itraconazole	47-59	immunoglobulin heavy constant epsilon	Homo sapiens	128-131