PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30690033-0	2019	Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway.	Itraconazole	0-12	thymoma viral proto-oncogene 1	Mus musculus	120-123	
30690033-6	2019	Importantly, itraconazole significantly reduced platelet-derived growth factor-D level, resulting in suppression of platelet-derived growth factor-beta activation and inhibition of its downstream effectors, such as PI3K, Akt, 4E-BP1, and p70S6K, which are important for cellular growth and survival of infantile hemangioma.	Itraconazole	13-25	thymoma viral proto-oncogene 1	Mus musculus	221-224	
28212537-9	2017	Furthermore, itraconazole significantly suppresses the PI3K/mTOR signaling pathway - indicated by the down-regulated phosphorylation of p70S6K, 4E-BP1 and AKT - but has no effect on the phosphorylation of MEK or ERK.	Itraconazole	13-25	thymoma viral proto-oncogene 1	Mus musculus	155-158	
34376577-0	2021	Itraconazole Exerts its Anti-Tumor Effect in Esophageal Cancer by Suppressing the HER2/AKT Signaling Pathway.	Itraconazole	0-12	thymoma viral proto-oncogene 1	Mus musculus	87-90	
34376577-8	2021	HER2 total protein and phosphorylation of AKT and S6 proteins were decreased in xenografts from itraconazole-treated mice compared to xenografts from placebo-treated mice.	Itraconazole	96-108	thymoma viral proto-oncogene 1	Mus musculus	42-45