PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30690033-0 2019 Itraconazole Induces Regression of Infantile Hemangioma via Downregulation of the Platelet-Derived Growth Factor-D/PI3K/Akt/mTOR Pathway. Itraconazole 0-12 platelet-derived growth factor, D polypeptide Mus musculus 82-114 30690033-6 2019 Importantly, itraconazole significantly reduced platelet-derived growth factor-D level, resulting in suppression of platelet-derived growth factor-beta activation and inhibition of its downstream effectors, such as PI3K, Akt, 4E-BP1, and p70S6K, which are important for cellular growth and survival of infantile hemangioma. Itraconazole 13-25 platelet-derived growth factor, D polypeptide Mus musculus 48-80 30690033-7 2019 In conclusion, our results suggest that platelet-derived growth factor-D is a target of itraconazole in infantile hemangioma. Itraconazole 88-100 platelet-derived growth factor, D polypeptide Mus musculus 40-72