PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34429859-4 2021 Here, we report that the antifungal compound itraconazole (ICZ), but not its main metabolite hydroxy-ICZ or ketoconazole, disrupts the binding of Rab7 to ORP3-VAP-A complexes, leading to inhibition of EV-mediated pro-metastatic morphological changes including cell migration behaviour of colon cancer cells. Itraconazole 45-57 RAB7B, member RAS oncogene family Homo sapiens 146-150 34429859-4 2021 Here, we report that the antifungal compound itraconazole (ICZ), but not its main metabolite hydroxy-ICZ or ketoconazole, disrupts the binding of Rab7 to ORP3-VAP-A complexes, leading to inhibition of EV-mediated pro-metastatic morphological changes including cell migration behaviour of colon cancer cells. Itraconazole 59-62 RAB7B, member RAS oncogene family Homo sapiens 146-150