PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28103683-0	2017	Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.	Itraconazole	44-56	NPC intracellular cholesterol transporter 1	Homo sapiens	26-30	
33315900-5	2020	A photo-crosslinking study confirmed direct binding of itraconazole to a representative folding-defective mutant protein, NPC1-I1061T.	Itraconazole	55-67	NPC intracellular cholesterol transporter 1	Homo sapiens	122-126	
32331453-4	2020	A recent cryo-EM structure has revealed an itraconazole binding site (IBS) in the SSD of human NPC1.	Itraconazole	43-55	NPC intracellular cholesterol transporter 1	Homo sapiens	95-99	
31919352-0	2020	Structural basis for itraconazole-mediated NPC1 inhibition.	Itraconazole	21-33	NPC intracellular cholesterol transporter 1	Homo sapiens	43-47	
31919352-3	2020	Previous studies suggest that mutation of the NPC1-SSD or the addition of the anti-fungal drug itraconazole abolishes NPC1 activity in cells.	Itraconazole	95-107	NPC intracellular cholesterol transporter 1	Homo sapiens	118-122	
31919352-5	2020	Here, we report a cryo-EM structure of human NPC1 bound to itraconazole, which reveals how this binding site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.	Itraconazole	59-71	NPC intracellular cholesterol transporter 1	Homo sapiens	45-49	
31919352-5	2020	Here, we report a cryo-EM structure of human NPC1 bound to itraconazole, which reveals how this binding site in the center of NPC1 blocks a putative lumenal tunnel linked to the SSD.	Itraconazole	59-71	NPC intracellular cholesterol transporter 1	Homo sapiens	126-130	
28103683-5	2017	In this study, we demonstrate that cholesterol trafficking inhibition by itraconazole is due to direct inhibition of the lysosomal protein NPC1.	Itraconazole	73-85	NPC intracellular cholesterol transporter 1	Homo sapiens	139-143	
28103683-6	2017	We further map the binding site of itraconazole to the sterol-sensing domain of NPC1 using mutagenesis, competition with U18666A, and molecular docking.	Itraconazole	35-47	NPC intracellular cholesterol transporter 1	Homo sapiens	80-84