PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17432820-5	2007	In attempts to delineate the mechanism of action of itraconazole, we found that human lanosterol 14alpha-demethylase (14DM) is essential for endothelial cell proliferation and may partially mediate the inhibition of endothelial cells by itraconazole.	Itraconazole	52-64	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	86-116	
1951574-9	1991	The triazole antifungals, terconazole and itraconazole, combine a high affinity for Candida P-45014DM with an exceptionally low effect on mammalian cytochrome P-450.	Itraconazole	42-54	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	92-101	
33102531-6	2020	The long-tailed inhibitors (posaconazole and itraconazole) have stronger binding affinities than short-tailed inhibitors (fluconazole and voriconazole) because long-tailed inhibitors can form more hydrophobic interactions with CYP51.	Itraconazole	45-57	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	227-232	
31514064-3	2019	It is shown how the transversal action of the azoles - fluconazole, posaconazole and itraconazole - in both fungi and Leishmania is due to the occurrence of the same target, lanosterol 14-alpha-demethylase, in these two groups of species.	Itraconazole	85-97	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	174-205	
27449014-5	2017	In particular, the first x-ray co-crystal structures of fungal CYP51 complexed with lanosterol and itraconazole are compared with co-crystal structures of other protozoal CYP51 enzymes.	Itraconazole	99-111	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	63-68	
27449014-5	2017	In particular, the first x-ray co-crystal structures of fungal CYP51 complexed with lanosterol and itraconazole are compared with co-crystal structures of other protozoal CYP51 enzymes.	Itraconazole	99-111	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	171-176	
17432820-5	2007	In attempts to delineate the mechanism of action of itraconazole, we found that human lanosterol 14alpha-demethylase (14DM) is essential for endothelial cell proliferation and may partially mediate the inhibition of endothelial cells by itraconazole.	Itraconazole	237-249	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	86-116	
16989930-10	2006	For the inhibition of hCYP51, IC(50) values split into two classes: the newer drugs fluconazole and itraconazole showed little inhibition (> or = 30 microM) while the older drugs were even more potent than the agricultural fungicides, with miconazole being the most potent (0.057 microM).	Itraconazole	100-112	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	22-28