PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23604141-0 2013 Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1. Azoles 11-17 cytochrome P450 family 46 subfamily A member 1 Homo sapiens 96-103 23604141-2 2013 CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally distinct azoles. Azoles 109-115 cytochrome P450 family 46 subfamily A member 1 Homo sapiens 0-7 23604141-8 2013 These and the solution studies with different marketed azoles, collectively, allowed us to identify the determinants of tight azole binding to CYP46A1 and generate an overall picture of azole binding to this important P450. Azoles 55-61 cytochrome P450 family 46 subfamily A member 1 Homo sapiens 143-150 23604141-8 2013 These and the solution studies with different marketed azoles, collectively, allowed us to identify the determinants of tight azole binding to CYP46A1 and generate an overall picture of azole binding to this important P450. Azoles 55-60 cytochrome P450 family 46 subfamily A member 1 Homo sapiens 143-150 23604141-8 2013 These and the solution studies with different marketed azoles, collectively, allowed us to identify the determinants of tight azole binding to CYP46A1 and generate an overall picture of azole binding to this important P450. Azoles 126-131 cytochrome P450 family 46 subfamily A member 1 Homo sapiens 143-150