PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29363861-3 2018 GOF forms of Pdr1 drive high level expression of downstream target gene expression with accompanying azole resistance. Azoles 101-106 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 13-17 31186322-4 2019 C. glabrata often acquires azole resistance via gain-of-function (GOF) mutations in the transcription factor Pdr1. Azoles 27-32 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 109-113 31186322-7 2019 Here we test the idea that reduction of ergosterol biosynthesis (as occurs in the presence of azole drugs) might trigger activation of Pdr1 function. Azoles 94-99 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 135-139 31186322-12 2019 Our studies argue for a physiological link between ergosterol biosynthesis and Pdr1-dependent gene regulation that is not restricted to efflux of azole drugs.IMPORTANCE A likely contributor to the increased incidence of non-albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly. Azoles 315-320 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 79-83 31186322-12 2019 Our studies argue for a physiological link between ergosterol biosynthesis and Pdr1-dependent gene regulation that is not restricted to efflux of azole drugs.IMPORTANCE A likely contributor to the increased incidence of non-albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly. Azoles 315-320 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 456-460 31186322-12 2019 Our studies argue for a physiological link between ergosterol biosynthesis and Pdr1-dependent gene regulation that is not restricted to efflux of azole drugs.IMPORTANCE A likely contributor to the increased incidence of non-albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly. Azoles 423-428 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 79-83 31186322-12 2019 Our studies argue for a physiological link between ergosterol biosynthesis and Pdr1-dependent gene regulation that is not restricted to efflux of azole drugs.IMPORTANCE A likely contributor to the increased incidence of non-albicans candidemias involving Candida glabrata is the ease with which this yeast acquires azole resistance, in large part due to induction of the ATP-binding cassette transporter-encoding gene CDR1 Azole drugs lead to induction of Pdr1 transactivation, with a central model being that this factor binds these drugs directly. Azoles 423-428 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 456-460 31186322-13 2019 Here we provide evidence that Pdr1 is activated without azole drugs by the use of genetic means to inhibit expression of azole drug target-encoding gene ERG11 These acute reductions in Erg11 levels lead to elevated Pdr1 activity even though no drug is present. Azoles 121-126 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 30-34 31186322-13 2019 Here we provide evidence that Pdr1 is activated without azole drugs by the use of genetic means to inhibit expression of azole drug target-encoding gene ERG11 These acute reductions in Erg11 levels lead to elevated Pdr1 activity even though no drug is present. Azoles 121-126 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 215-219 30056490-0 2019 Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance. Azoles 97-102 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 61-65 29363861-1 2018 Resistance to azole drugs, the major clinical antifungal compounds, is most commonly due to gain-of-function (GOF) substitution mutations in a gene called PDR1 in the fungal pathogen Candida glabrata. Azoles 14-19 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 155-159 29363861-10 2018 A full understanding of the regulation of Pdr1 will provide a new avenue of interfering with azole resistance in C. glabrata. Azoles 93-98 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 42-46 17202662-3 2007 A previous study has showed that for fluconazole resistance 1 (FCR1) could also confer azole resistance in S. cerevisiae pdr1 pdr3 mutant by regulating PDR5. Azoles 43-48 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 121-125 23229483-5 2013 Resistance to azoles is largely mediated by the transcription factor PDR1, resulting in the upregulation of ATP-binding cassette (ABC) transporter proteins and drug efflux. Azoles 14-20 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 69-73 18451058-8 2008 They could also confer resistance to azoles in a S. cerevisiae strain lacking PDR1, PDR3 and PDR5, suggesting that CTA4-, ASG1- and CTF1-dependent azole resistance can be caused by genes other than PDR5 in S. cerevisiae. Azoles 37-43 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 78-82 18451058-8 2008 They could also confer resistance to azoles in a S. cerevisiae strain lacking PDR1, PDR3 and PDR5, suggesting that CTA4-, ASG1- and CTF1-dependent azole resistance can be caused by genes other than PDR5 in S. cerevisiae. Azoles 37-42 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 78-82 16569856-0 2006 Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants. Azoles 102-107 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 17-21 16803598-3 2006 We previously reported that azole-resistant mutants (MIC >or= 64 microg ml(-1)) of strain 66032 (MIC = 16 microg ml(-1)) similarly show coordinate CDR1-PDH1 upregulation, and in one of these (F15) a putative gain-of-function mutation was identified in the single homologue of Saccharomyces cerevisiae transcription factors Pdr1-Pdr3. Azoles 28-33 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 326-330 16803598-5 2006 Reintroduction of wild-type or F15 PDR1 fully reversed these effects; together these results demonstrate a role for this gene in both acquired and intrinsic azole resistance. Azoles 157-162 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 35-39 16803598-7 2006 In an azole-resistant clinical isolate, PDR1 disruption reduced azole MICs eight- to 64-fold with no effect on sensitivity to other antifungals. Azoles 6-11 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 40-44 16803598-7 2006 In an azole-resistant clinical isolate, PDR1 disruption reduced azole MICs eight- to 64-fold with no effect on sensitivity to other antifungals. Azoles 64-69 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 40-44