PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16796687-0 2006 PDR16-mediated azole resistance in Candida albicans. Azoles 15-20 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 0-5 16796687-3 2006 It has been reported that S. cerevisiae pdr16Delta mutants are hypersusceptible to azoles, suggesting that C. albicans PDR16 may contribute to azole resistance in these isolates. Azoles 83-89 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 119-124 16796687-3 2006 It has been reported that S. cerevisiae pdr16Delta mutants are hypersusceptible to azoles, suggesting that C. albicans PDR16 may contribute to azole resistance in these isolates. Azoles 83-88 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 119-124 16796687-5 2006 Our results show that the homozygous pdr16Delta/pdr16Delta mutant is approximately twofold less resistant to azoles than the parental strain whereas reintroducing a copy of PDR16 in the mutant restored azole resistance, demonstrating that this gene contributes to the AR phenotype of the cells. Azoles 109-115 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 173-178 16796687-5 2006 Our results show that the homozygous pdr16Delta/pdr16Delta mutant is approximately twofold less resistant to azoles than the parental strain whereas reintroducing a copy of PDR16 in the mutant restored azole resistance, demonstrating that this gene contributes to the AR phenotype of the cells. Azoles 109-114 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 173-178 16796687-6 2006 In addition, overexpression of PDR16 in azole-susceptible (AS) C. albicans and S. cerevisiae strains increased azole resistance by about twofold, indicating that an increased dosage of Pdr16p can confer low levels of azole resistance in the absence of additional molecular alterations. Azoles 40-45 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 31-36 16796687-6 2006 In addition, overexpression of PDR16 in azole-susceptible (AS) C. albicans and S. cerevisiae strains increased azole resistance by about twofold, indicating that an increased dosage of Pdr16p can confer low levels of azole resistance in the absence of additional molecular alterations. Azoles 40-45 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 185-191 16796687-6 2006 In addition, overexpression of PDR16 in azole-susceptible (AS) C. albicans and S. cerevisiae strains increased azole resistance by about twofold, indicating that an increased dosage of Pdr16p can confer low levels of azole resistance in the absence of additional molecular alterations. Azoles 111-116 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 31-36 16796687-6 2006 In addition, overexpression of PDR16 in azole-susceptible (AS) C. albicans and S. cerevisiae strains increased azole resistance by about twofold, indicating that an increased dosage of Pdr16p can confer low levels of azole resistance in the absence of additional molecular alterations. Azoles 111-116 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 185-191 16796687-6 2006 In addition, overexpression of PDR16 in azole-susceptible (AS) C. albicans and S. cerevisiae strains increased azole resistance by about twofold, indicating that an increased dosage of Pdr16p can confer low levels of azole resistance in the absence of additional molecular alterations. Azoles 111-116 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 31-36 16796687-6 2006 In addition, overexpression of PDR16 in azole-susceptible (AS) C. albicans and S. cerevisiae strains increased azole resistance by about twofold, indicating that an increased dosage of Pdr16p can confer low levels of azole resistance in the absence of additional molecular alterations. Azoles 111-116 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 185-191 16796687-7 2006 Taken together, these results demonstrate that PDR16 plays a role in C. albicans azole resistance. Azoles 81-86 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 47-52 25066473-0 2014 Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals. Azoles 157-162 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 57-63 15105111-3 2004 Homologues of three of these genes have been implicated in azole and/or drug resistance in Saccharomyces cerevisiae: two of these belong to the family of ABC transporters (PDR5 and PDR16), and one is involved in retrograde signaling from mitochondria to nucleus (RTG2). Azoles 59-64 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 181-186 9890948-3 1999 Deletion of PDR16 resulted in hypersensitivity of yeast to azole inhibitors of ergosterol biosynthesis. Azoles 59-64 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 12-17 9890948-8 1999 The azole sensitivity of the PDR16-deleted strain may be the result of imbalanced ergosterol synthesis. Azoles 4-9 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 29-34 32451851-1 2020 In yeast, the PDR16 gene encodes one of the PITP proteins involved in lipid metabolism and is regarded as a factor involved in clinical azole resistance of fungal pathogens. Azoles 136-141 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 14-19 25066473-1 2014 Pdr16p is considered a factor of clinical azole resistance in fungal pathogens. Azoles 42-47 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 0-6 25066473-2 2014 The most distinct phenotype of yeast cells lacking Pdr16p is their increased susceptibility to azole and morpholine antifungals. Azoles 95-100 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 51-57 23606207-0 2013 The yeast Saccharomyces cerevisiae Pdr16p restricts changes in ergosterol biosynthesis caused by the presence of azole antifungals. Azoles 113-118 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 35-41 23606207-2 2013 The absence of Pdr16p results in enhanced susceptibility to azole antifungals in Saccharomyces cerevisiae. Azoles 60-65 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 15-21 23606207-4 2013 The current study was aimed at better understanding the function of Pdr16p, especially in relation to azole resistance in S. cerevisiae. Azoles 102-107 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 68-74 23606207-5 2013 We show that deletion of the PDR16 gene increased susceptibility of S. cerevisiae to azole antifungals that are used in clinical medicine and agriculture. Azoles 85-90 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 29-34