PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21367996-8 2011 Mutations were also identified in the ERG11 and the TAC1 genes of isolates from these four patients; some of these mutations have previously been associated with azole resistance. Azoles 162-167 tachykinin precursor 1 Homo sapiens 52-56 30858206-6 2019 Several antagonistic agents selected for follow-up studies induce azole resistance through a mechanism that depends on Tac1p/Pdr1p zinc-cluster transcription factors, which activate the expression of drug efflux pumps belonging to the ABC-type transporter family. Azoles 66-71 tachykinin precursor 1 Homo sapiens 119-124 27697142-12 2016 Increased expression levels of azole efflux pumps were probably accredited to novel gain-of-function variants in the transcription factor TAC1 (R688Q and R673L). Azoles 31-36 tachykinin precursor 1 Homo sapiens 138-142 20876623-8 2010 The major molecular mechanisms behind the azole resistance were mutations in TAC1 contributing to overexpression of CDR1 and CDR2. Azoles 42-47 tachykinin precursor 1 Homo sapiens 77-81 18363649-6 2008 Thus, the major mechanism by which i(5L) formation causes increased azole resistance is by amplifying two genes: ERG11 and TAC1. Azoles 68-73 tachykinin precursor 1 Homo sapiens 123-127