PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21367996-8	2011	Mutations were also identified in the ERG11 and the TAC1 genes of isolates from these four patients; some of these mutations have previously been associated with azole resistance.	Azoles	162-167	tachykinin precursor 1	Homo sapiens	52-56	
18363649-6	2008	Thus, the major mechanism by which i(5L) formation causes increased azole resistance is by amplifying two genes: ERG11 and TAC1.	Azoles	68-73	tachykinin precursor 1	Homo sapiens	123-127	
20876623-8	2010	The major molecular mechanisms behind the azole resistance were mutations in TAC1 contributing to overexpression of CDR1 and CDR2.	Azoles	42-47	tachykinin precursor 1	Homo sapiens	77-81	
27697142-12	2016	Increased expression levels of azole efflux pumps were probably accredited to novel gain-of-function variants in the transcription factor TAC1 (R688Q and R673L).	Azoles	31-36	tachykinin precursor 1	Homo sapiens	138-142	
30858206-6	2019	Several antagonistic agents selected for follow-up studies induce azole resistance through a mechanism that depends on Tac1p/Pdr1p zinc-cluster transcription factors, which activate the expression of drug efflux pumps belonging to the ABC-type transporter family.	Azoles	66-71	tachykinin precursor 1	Homo sapiens	119-124