PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10567951-7	1999	Furthermore, signal transduction for the regulation of ICAM-1 by PGF2 alpha was investigated using N-(6-aminohexyl)-5-chloro-1-naphthalenesulphonamide (W-7), a calcium calmodulin antagonist, and 1-(5-isoquinolinylsulphonyl)-2-methylpiperazine (H-7), an inhibitor of protein kinase C (PKC).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	244-247	intercellular adhesion molecule 1	Homo sapiens	55-61	
11164475-13	2000	Inhibition studies showed that 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H7), a protein kinase C (PKC) inhibitor, not only abolished most of PMA-induced ICAM-1 expression and PGE2, production, but also eliminated GSH depletion-enhanced PMA stimulation.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	31-77	intercellular adhesion molecule 1	Homo sapiens	159-165	
11164475-13	2000	Inhibition studies showed that 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H7), a protein kinase C (PKC) inhibitor, not only abolished most of PMA-induced ICAM-1 expression and PGE2, production, but also eliminated GSH depletion-enhanced PMA stimulation.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	79-81	intercellular adhesion molecule 1	Homo sapiens	159-165	
9124598-4	1997	These hyperoxia-induced ICAM-1 expressions were dose dependently attenuated by a protein kinase C inhibitor (H-7).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	109-112	intercellular adhesion molecule 1	Homo sapiens	24-30	
2244911-5	1990	Staurosporine (STS) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented inflammatory mediator-dependent stimulation of both ICAM-1 expression and PMN adherence by HUVEC (ID50 for STS = 2.7-2.9 microM; for H-7 = 7.6-8.8 microM).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	24-70	intercellular adhesion molecule 1	Homo sapiens	139-145	
7524973-6	1994	RESULTS: HSVEC adherent to ePTFE constitutively bound anti-ICAM-1 antibodies, which were attenuated by the protein kinase C inhibitor, H-7.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	135-138	intercellular adhesion molecule 1	Homo sapiens	59-65	
7908744-2	1994	Expression of PKC activator-induced ICAM-1 in HUVEC was inhibited by the PKC inhibitor, H-7.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	88-91	intercellular adhesion molecule 1	Homo sapiens	36-42	
1347198-5	1992	The protein kinase inhibitor H-7 blocked induction of ICAM-1 by all of the activators; nonlinear regression analysis revealed 50% inhibitory concentration (IC50) values of 6-10 microM.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	29-32	intercellular adhesion molecule 1	Homo sapiens	54-60	
2244911-5	1990	Staurosporine (STS) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented inflammatory mediator-dependent stimulation of both ICAM-1 expression and PMN adherence by HUVEC (ID50 for STS = 2.7-2.9 microM; for H-7 = 7.6-8.8 microM).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	72-75	intercellular adhesion molecule 1	Homo sapiens	139-145