PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7927239-6	1994	The epidermal growth factor-induced intracellular pH increase was inhibited by pretreatment of hepatocytes with genistein (100 mumol/L), thapsigargin (3 mumol/L) or calmodulin inhibitor W-7 (25 mumol/L), but not with protein kinase C inhibitor H-7 (50 mumol/L) or with cyclic AMP-dependent kinase inhibitor H-8 (60 mumol/L).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	244-247	epidermal growth factor	Homo sapiens	4-27	
2114514-1	1990	In an attempt to elucidate possible mechanism(s) for stimulated arachidonic acid metabolism by phorbol 12-myristate 13-acetate (PMA) and epidermal growth factor (EGF) in porcine thyroid cells, we examined the effects of protein kinase inhibitors, isoquinolinesulfonamide derivatives (H-7 and HA-1004), and cycloheximide.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	284-287	epidermal growth factor	Homo sapiens	162-165	
2114514-5	1990	The EGF- and PMA-stimulated release of 3H-arachidonic acid from the cells was also strongly inhibited by H-7 and cycloheximide.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	105-108	epidermal growth factor	Homo sapiens	4-7	
14610335-6	2003	On the other hand, EGF-induced inhibition of Pi uptake was blocked by staurosporine, H-7, or bisindolylmaleimide I (PKC inhibitors), PD 98059 (a p44/42 MAPK inhibitor), but not by SB 203580 (a p38 MAPK inhibitor).	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	85-88	epidermal growth factor	Homo sapiens	19-22	
9525871-9	1998	Protein kinase C inhibitors (H7, staurosporin, and chelerythrine) inhibited EGF-induced CREB phosphorylation, whereas either mitogen-activated protein kinase kinase-1 inhibitor (PD98059) or protein kinase A inhibitor (H8) showed no effect.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	29-31	epidermal growth factor	Homo sapiens	76-79	
8913498-5	1996	In contrast, the PKC inhibitor of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) effectively suppressed the translational regulation of proMMP-3 and TIMP-1 in a dose-dependent manner during the first 2-h treatment with EGF.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	97-100	epidermal growth factor	Homo sapiens	240-243	
1427596-10	1992	However, this effect of EGF was counteracted by the pretreatment with TPA or H-7.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	77-80	epidermal growth factor	Homo sapiens	24-27	
2022708-15	1991	Other enzymes that are inhibited by H7 and staurosporine are implicated in the production of PGE2 caused by EGF.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	36-38	epidermal growth factor	Homo sapiens	108-111