PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2584705-7	1989	In contrast, IL-2 induction of IL-1 beta mRNA expression is blocked only by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, suggesting that PKc, and not CaM kinase, is activated by IL-2.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	76-121	interleukin 2	Homo sapiens	13-17	
8258686-4	1993	Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7) or the tyrosine kinase inhibitor, genistein.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	220-222	interleukin 2	Homo sapiens	28-32	
7904541-4	1994	Thus, the inhibitors H-7, staurosporine, and genistein exerted a dose-dependent inhibition of CD2 up-regulation, CD25 expression, IL-2 production, and cellular proliferation.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	21-24	interleukin 2	Homo sapiens	130-134	
1783463-7	1991	Both the OAG and the IL-2 positive inotropic effects could be prevented by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine (H7) but were poorly inhibited by N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004), an inhibitor of the cyclic nucleotide-dependent protein kinases.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	106-152	interleukin 2	Homo sapiens	21-25	
1783463-7	1991	Both the OAG and the IL-2 positive inotropic effects could be prevented by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine (H7) but were poorly inhibited by N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004), an inhibitor of the cyclic nucleotide-dependent protein kinases.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	154-156	interleukin 2	Homo sapiens	21-25	
3100062-1	1986	1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	0-46	interleukin 2	Homo sapiens	93-106	
3100062-1	1986	1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	0-46	interleukin 2	Homo sapiens	108-112	
3100062-1	1986	1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	48-51	interleukin 2	Homo sapiens	93-106	
3100062-1	1986	1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	48-51	interleukin 2	Homo sapiens	108-112