PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7904541-4 1994 Thus, the inhibitors H-7, staurosporine, and genistein exerted a dose-dependent inhibition of CD2 up-regulation, CD25 expression, IL-2 production, and cellular proliferation. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 21-24 interleukin 2 Homo sapiens 130-134 2584705-7 1989 In contrast, IL-2 induction of IL-1 beta mRNA expression is blocked only by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine, suggesting that PKc, and not CaM kinase, is activated by IL-2. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 76-121 interleukin 2 Homo sapiens 13-17 3100062-1 1986 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 0-46 interleukin 2 Homo sapiens 93-106 3100062-1 1986 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 0-46 interleukin 2 Homo sapiens 108-112 3100062-1 1986 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 48-51 interleukin 2 Homo sapiens 93-106 3100062-1 1986 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a protein kinase inhibitor, suppressed interleukin 2 (IL-2) production and IL-2 receptor (IL-2R) expression of the human leukemic T-cell line, Jurkat, induced by 12-O-tetradecanoyl-phorbol-13-acetate and phytohemagglutinin-P. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 48-51 interleukin 2 Homo sapiens 108-112 1783463-7 1991 Both the OAG and the IL-2 positive inotropic effects could be prevented by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine (H7) but were poorly inhibited by N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004), an inhibitor of the cyclic nucleotide-dependent protein kinases. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 106-152 interleukin 2 Homo sapiens 21-25 8258686-4 1993 Our study demonstrated that IL-2, IL-4, and IL-6-stimulation of IgM secretion by SKW6.4 cells was inhibited by either the serine/threonine kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H7) or the tyrosine kinase inhibitor, genistein. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 220-222 interleukin 2 Homo sapiens 28-32 1783463-7 1991 Both the OAG and the IL-2 positive inotropic effects could be prevented by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine (H7) but were poorly inhibited by N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA1004), an inhibitor of the cyclic nucleotide-dependent protein kinases. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 154-156 interleukin 2 Homo sapiens 21-25