PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7638737-9 1995 Addition of 8-bromo-cyclic adenosine monophosphate, H7, or nitroprusside prevented LPSp-induced augmentation of IL-1 but had no effect on inhibition of TNF release. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 52-54 interleukin 1 alpha Homo sapiens 112-116 8807591-9 1996 The IL-1-induced-sTNF-R1-shedding was suppressed by the protein-kinase-A (PKA) inhibitor, H-8, or by H-7, the inhibitor of both PKC and PKA, but not by the specific PKC inhibitor GF. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 101-104 interleukin 1 alpha Homo sapiens 4-8 2508093-5 1989 The protein kinase C inhibitor 1-(isoquinolinsulfonyl)-2-methylpiperazine (H7) inhibited IL-1-mediated increase of the level of APP transcripts. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 75-77 interleukin 1 alpha Homo sapiens 89-93 7886628-10 1994 Only the PKC inhibitor H-7 reduced the augmentation that IL1 produces on CRF synthesis. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 23-26 interleukin 1 alpha Homo sapiens 57-60 8588070-3 1995 Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 90-93 interleukin 1 alpha Homo sapiens 15-25 8268245-2 1993 IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 321-324 interleukin 1 alpha Homo sapiens 0-4 8268245-3 1993 The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 26-29 interleukin 1 alpha Homo sapiens 55-59