PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8807591-9	1996	The IL-1-induced-sTNF-R1-shedding was suppressed by the protein-kinase-A (PKA) inhibitor, H-8, or by H-7, the inhibitor of both PKC and PKA, but not by the specific PKC inhibitor GF.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	101-104	interleukin 1 alpha	Homo sapiens	4-8	
7638737-9	1995	Addition of 8-bromo-cyclic adenosine monophosphate, H7, or nitroprusside prevented LPSp-induced augmentation of IL-1 but had no effect on inhibition of TNF release.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	52-54	interleukin 1 alpha	Homo sapiens	112-116	
7886628-10	1994	Only the PKC inhibitor H-7 reduced the augmentation that IL1 produces on CRF synthesis.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	23-26	interleukin 1 alpha	Homo sapiens	57-60	
2508093-5	1989	The protein kinase C inhibitor 1-(isoquinolinsulfonyl)-2-methylpiperazine (H7) inhibited IL-1-mediated increase of the level of APP transcripts.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	75-77	interleukin 1 alpha	Homo sapiens	89-93	
8588070-3	1995	Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	90-93	interleukin 1 alpha	Homo sapiens	15-25	
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	321-324	interleukin 1 alpha	Homo sapiens	0-4	
8268245-3	1993	The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs.	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine	26-29	interleukin 1 alpha	Homo sapiens	55-59