PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9287052-7 1997 High glucose concentrations activate protein kinase C (PKC) in human VSM cells, and PKC inhibitors (H-7 or chelerythrine chloride) or PKC downregulation each prevented the glucose-induced increases in VPF mRNA expression by human VSM cells. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 100-103 vascular endothelial growth factor A Homo sapiens 201-204 8992878-8 1996 The VEGF mRNA expression induced by 1,25-(OH)2D3 was completely inhibited by H-7, but only partially by staurosporine. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 77-80 vascular endothelial growth factor A Homo sapiens 4-8 8304487-3 1994 Removal of fetal bovine serum (FBS) from the culture medium for 2 h decreased VEGF mRNA abundance, which was restored by the readdition of FBS (10%) within 2 h. The effect of FBS was completely abolished by protein kinase inhibitor H-7 (10 microM), suggesting that FBS-stimulated VEGF mRNA induction involves activation of protein kinases. 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 232-235 vascular endothelial growth factor A Homo sapiens 78-82