PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6410656-1 1983 A temporal and causal relationship has been established between inhibition of acetylcholinesterase (AChE) by organophosphorous compounds, accumulation of Ca2+, an increase of neutral protease activity and the development of the ultrastructural signs of subacute myopathy. organophosphorous 109-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 2215205-3 1990 Organophosphorous chemicals induce inhibition of AChE activity thus leading to nervous system impairment. organophosphorous 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 2547555-0 1989 [Post- and presynaptic mechanisms of restoring nerve-muscle transmission with tubocurarine after the effect of an organophosphorous inhibitor of acetylcholinesterase]. organophosphorous 114-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-166 1595894-1 1992 A flow injection system, incorporating an acetylcholinesterase (AChE) single bead string reactor (SBSR), for the determination of some organophosphorous (azinphos-ethyl, azinphos-methyl, bromophos-methyl, dichlorovos, fenitrothion, malathion, paraoxon, parathion-ethyl and parathion-methyl) and carbamate insecticides (carbofuran and carbaryl) is presented. organophosphorous 135-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 6410656-1 1983 A temporal and causal relationship has been established between inhibition of acetylcholinesterase (AChE) by organophosphorous compounds, accumulation of Ca2+, an increase of neutral protease activity and the development of the ultrastructural signs of subacute myopathy. organophosphorous 109-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 580736-1 1978 A preliminary test for the diagnosis of intoxications with organophosphorous pesticides in fatal cases is described, based on the fact that these compounds inhibit AChE activity. organophosphorous 59-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 580736-2 1978 For this purpose we measured AChE activity in CSF in 30 samples from fresh bodies autopsied after traffic accidents and in six after poisoning with organophosphorous insecticides. organophosphorous 148-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 31054518-0 2019 Visual detection of mixed organophosphorous pesticide using QD-AChE aerogel based microfluidic arrays sensor. organophosphorous 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 4941499-0 1971 [Acetylcholinesterase activity in acute and chronic poisoning with organophosphorous inhibitions]. organophosphorous 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 1-21 5559195-0 1971 Clinical features and plasma acetylcholinesterase activity in poisoning with insecticidal organophosphorous compounds. organophosphorous 90-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. organophosphorous 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. organophosphorous 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 30052145-5 2020 This sensor worked on the AChE inhibition mechanism where the signal is inversely proportional to the amount of organophosphorous compounds. organophosphorous 112-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. organophosphorous 310-327 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 30625376-0 2019 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. organophosphorous 142-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 30096649-1 2018 Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. organophosphorous 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 30096649-1 2018 Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. organophosphorous 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. organophosphorous 310-327 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 27016441-3 2016 The presence of organophosphorous pesticides (OPs) can inhibit the AChE activity and thus changes the fluorescent intensity of QDs/AChE microscopic dot arrays. organophosphorous 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 27016441-3 2016 The presence of organophosphorous pesticides (OPs) can inhibit the AChE activity and thus changes the fluorescent intensity of QDs/AChE microscopic dot arrays. organophosphorous 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 20466535-0 2010 Acetylcholinesterase biosensor based on Prussian blue-modified electrode for detecting organophosphorous pesticides. organophosphorous 87-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25874456-1 2015 Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. organophosphorous 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-62 24076173-1 2013 The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. organophosphorous 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 24076173-1 2013 The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. organophosphorous 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 23474396-1 2013 The aim of this work was to examine the effect of two organophosphorous compounds i.e. bromfenvinphos (BFVF) and chlorfenvinphos (CFVF) possessing acaricidal and insecticidal properties, on the activity of human erythrocytes acetylcholinesterase (AChE, EC 3.1.1.7). organophosphorous 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-245 23474396-1 2013 The aim of this work was to examine the effect of two organophosphorous compounds i.e. bromfenvinphos (BFVF) and chlorfenvinphos (CFVF) possessing acaricidal and insecticidal properties, on the activity of human erythrocytes acetylcholinesterase (AChE, EC 3.1.1.7). organophosphorous 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-251 25920465-1 2015 Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. organophosphorous 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25920465-1 2015 Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. organophosphorous 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26153025-1 2015 In this work, we studied the attachment of active acetylcholinesterase (AChE) enzyme on a silicon substrate as a potential biomarker for the detection of organophosphorous (OP) pesticides. organophosphorous 154-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 26153025-1 2015 In this work, we studied the attachment of active acetylcholinesterase (AChE) enzyme on a silicon substrate as a potential biomarker for the detection of organophosphorous (OP) pesticides. organophosphorous 154-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 22726956-3 2012 AChE is the specific target of organophosphorous pesticides and warfare nerve agents, and BChE is a stoichiometric bioscavenger. organophosphorous 31-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21196108-0 2011 Highly-sensitive organophosphorous pesticide biosensors based on nanostructured films of acetylcholinesterase and CdTe quantum dots. organophosphorous 17-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 21516778-0 2011 [Molecular modeling of acetylcholinesterase interaction with irreversible and reversible organophosphorous inhibitors]. organophosphorous 89-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 17499494-0 2007 Immobilization of acetylcholinesterase on gold nanoparticles embedded in sol-gel film for amperometric detection of organophosphorous insecticide. organophosphorous 116-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 20096330-1 2010 The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). organophosphorous 19-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 20096330-1 2010 The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). organophosphorous 19-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 17499494-1 2007 A simple method to immobilize acetylcholinesterase (AChE) on silica sol-gel (SiSG) film assembling gold nanoparticles (AuNPs) was proposed, thus a sensitive, fast and stable amperometric sensor for quantitative determination of organophosphorous insecticide was developed. organophosphorous 228-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 17499494-1 2007 A simple method to immobilize acetylcholinesterase (AChE) on silica sol-gel (SiSG) film assembling gold nanoparticles (AuNPs) was proposed, thus a sensitive, fast and stable amperometric sensor for quantitative determination of organophosphorous insecticide was developed. organophosphorous 228-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 17499494-5 2007 Based on the inhibition of organophosphorous insecticide on the enzymatic activity of AChE, using monocrotophos as a model compound, the conditions for detection of the insecticide were optimized. organophosphorous 27-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 16149071-1 2005 The biological effects of organophosphorous (OP) chemical warfare nerve agents (CWNAs) are exerted by inhibition of acetylcholinesterase (AChE), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. organophosphorous 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 17125036-2 2006 Numerous toxicologists still believe that the only function of acetylcholinesterase (AChE) is to catalyse the hydrolysis of acetylcholine (ACh), and that the toxicity of organophosphorous pesticides (OP) results from their ability to switch this function off. organophosphorous 170-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 16240314-0 2006 Binding of acetylcholinesterase to multiwall carbon nanotube-cross-linked chitosan composite for flow-injection amperometric detection of an organophosphorous insecticide. organophosphorous 141-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 16240314-6 2006 Based on the inhibition of an organophosphorous insecticide on the enzymatic activity of AChE, using Sulfotep as a model compound, the conditions for the flow-injection detection of the insecticide were optimized. organophosphorous 30-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 16149071-1 2005 The biological effects of organophosphorous (OP) chemical warfare nerve agents (CWNAs) are exerted by inhibition of acetylcholinesterase (AChE), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. organophosphorous 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 12099619-0 2002 Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. organophosphorous 69-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 15494248-7 2004 Acetylcholinesterase is used to detect organophosphorous and carbamate insecticide residues but several molecules (reversible inhibitors, pH and ionic strength modifiers) generate matrix effects in free conditions. organophosphorous 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11341928-1 2001 The influence of inorganic salts on the inhibition of acetylcholinesterase by charged organophosphorous inhibitors has been studied. organophosphorous 86-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 11568366-1 2001 Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. organophosphorous 11-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 11568366-1 2001 Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. organophosphorous 11-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 11568366-5 2001 Our models can be useful in screening databases of organophosphorous compounds for their neurotoxicity potential via the inhibition of acetylcholinesterase. organophosphorous 51-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 10998265-1 2000 Acetylcholinesterase is the primary target of organophosphorous and carbamate insecticides. organophosphorous 46-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9187246-5 1997 Titration of active sites with an organophosphorous agent (MPT) revealed that the AChE of all venoms have similar turnovers (6000 to 8000 s(-1)) which are clearly higher than those of Torpedo and mammalian enzymes but lower than that of Electrophorus. organophosphorous 34-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 10679638-1 2000 A highly sensitive flow analysis method for determination of acetylcholinesterase (AChE) inhibitors like organophosphorous pesticides using a new chemiluminescent reaction was developed and optimized. organophosphorous 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 10679638-1 2000 A highly sensitive flow analysis method for determination of acetylcholinesterase (AChE) inhibitors like organophosphorous pesticides using a new chemiluminescent reaction was developed and optimized. organophosphorous 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9054171-1 1996 The antienzymic activities of 14 organophosphorous compounds, the derivatives of dialkyl thiophosphoric acid, towards the acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and carboxylesterase (CE) from the spring grain aphid and mammals were investigated. organophosphorous 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148