PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10677483-9	2000	Alignment of cleavage site sequences of peptides indicates that the specificity of memapsin 2 resides mainly at the S(1)" subsite, which prefers small side chains such as Ala, Ser, and Asp.	Alanine	171-174	beta-secretase 1	Homo sapiens	83-93	
16033761-8	2005	In contrast, the BACE-LL/AA mutant, in which Leu(499) and Leu(500) in the COOH-terminal sequence (DDISLLK) were replaced by alanines, only partially co-localized with LAMP2-positive compartments following inhibition of lysosomal hydrolases.	Alanine	124-132	beta-secretase 1	Homo sapiens	17-21	
12551920-4	2003	We found that BACE undergoes cleavage on a surface-exposed alpha-helix between amino acid residues Leu-228 and Ala-229, generating stable N- and C-terminal fragments that remain covalently associated via a disulfide bond.	Alanine	111-114	beta-secretase 1	Homo sapiens	14-18	
14684335-1	2004	We describe herein the syntheses and evaluation of a series of C-termini pyridyl containing Phe*-Ala-based BACE inhibitors (5-19).	Alanine	97-100	beta-secretase 1	Homo sapiens	107-111	
14684336-0	2004	P3 cap modified Phe*-Ala series BACE inhibitors.	Alanine	21-24	beta-secretase 1	Homo sapiens	32-36	
30038319-6	2018	We identified and validated by alanine-scanning mutagenesis the role of three functionally relevant residues: Cys2676.55, Phe1203.36 and Asp2.50.	Alanine	31-38	beta-secretase 1	Homo sapiens	137-141	
10574939-8	1999	Alanine-scanning mutagenesis identified several charged and aromatic residues (Asp-2, Tyr-3, Tyr-10, Asp-11, and Glu-18) that played an important role in both chemokine and Env high affinity binding.	Alanine	0-7	beta-secretase 1	Homo sapiens	79-84	
19074428-7	2009	We demonstrate that BACE1 undergoes S-palmitoylation at four Cys residues at the junction of transmembrane and cytosolic domains, and Ala substitution at these four residues is sufficient to displace BACE1 from lipid rafts.	Alanine	134-137	beta-secretase 1	Homo sapiens	200-205