PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Alanine 250-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 14622273-9 2003 The observation that the KI value for mutant AChE in which Ala replaced Trp286 is similar to that for wild-type BChE, further confirms our hypothesis. Alanine 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 12132693-0 2002 Alanine reverses the inhibitory effect of phenylalanine on acetylcholinesterase activity. Alanine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 180-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 180-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Alanine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Alanine 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-8 2002 Ala reversed the inhibited AChE by Phe in erythrocyte membranes from healthy children to control values, whereas no reverse effect was observed on the enzyme activity from PKU patients. Alanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 12132693-2 2002 AChE activity was determined in brain homogenates and in the pure enzyme after 1 h preincubation with 1.2 mM of Phe or Ala as well as with Phe plus Ala. Alanine 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12132693-4 2002 Ala reversed completely the inhibited AChE by Phe (18-20% in 500-600 microM substrate, p<0.01). Alanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 11904227-8 2002 Thus a single amino acid substitution in the pi-cation site, from the aromatic tyrosine of B. fasciatus AChE to the alanine of BuChE, caused AChE to behave like BuChE. Alanine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 11904227-8 2002 Thus a single amino acid substitution in the pi-cation site, from the aromatic tyrosine of B. fasciatus AChE to the alanine of BuChE, caused AChE to behave like BuChE. Alanine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 3306451-6 1987 Acetylcholinesterase more slowly cleaved the C-terminal alanine residue from the peptide to yield LWMRF. Alanine 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1517212-2 1992 Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues. Alanine 168-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 26200472-6 2015 Replacement of hAChE residues known to be essential for its interaction with Fas with alanine, in this peptide, resulted in almost complete loss of binding to Fas. Alanine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-20