PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18718528-8	2008	In contrast, mutation of S396 to alanine reduced PDK1 nuclear localization and reduced PKB phosphorylation and activation.	Alanine	33-40	protein tyrosine kinase 2 beta	Homo sapiens	87-90	
26925779-6	2016	In particular, a functionally critical STK-conserved histidine that stabilizes the regulatory spine in STKs is selectively mutated to an alanine, serine or glutamate in PTKs, and this loss-of-function mutation is accommodated, in part, through compensatory PTK-specific interactions in the core.	Alanine	137-144	protein tyrosine kinase 2 beta	Homo sapiens	169-172	
10330141-10	1999	PKBalpha with alanine substitutions T308A and S473A (AA-PKB) or K179A (A-PKB) alone was a less potent inhibitor of insulin-dependent activation of wild-type HA-PKB or GLUT4myc translocation than was AAA-PKB.	Alanine	14-21	protein tyrosine kinase 2 beta	Homo sapiens	0-3	
17030608-5	2006	Mutation of both serines to alanine uncouples BRF1 from PKB regulation, leading to constitutive mRNA decay even in the presence of stabilizing signals.	Alanine	28-35	protein tyrosine kinase 2 beta	Homo sapiens	56-59	
16129678-5	2005	Unexpectedly, after acute insulin stimulation, we observed that phosphorylation of Ser(318) is not inhibitory but rather enhances insulin signal transduction because introduction of Ala(318) led to a reduction of the insulin-stimulated Akt/protein kinase B phosphorylation.	Alanine	182-185	protein tyrosine kinase 2 beta	Homo sapiens	240-256	
10373549-5	1999	These data were supported by the fact that mutation of residue S473 of PKB to alanine did not prevent it from being activated by forskolin.	Alanine	78-85	protein tyrosine kinase 2 beta	Homo sapiens	71-74	
10330141-10	1999	PKBalpha with alanine substitutions T308A and S473A (AA-PKB) or K179A (A-PKB) alone was a less potent inhibitor of insulin-dependent activation of wild-type HA-PKB or GLUT4myc translocation than was AAA-PKB.	Alanine	14-21	protein tyrosine kinase 2 beta	Homo sapiens	56-59	
10330141-10	1999	PKBalpha with alanine substitutions T308A and S473A (AA-PKB) or K179A (A-PKB) alone was a less potent inhibitor of insulin-dependent activation of wild-type HA-PKB or GLUT4myc translocation than was AAA-PKB.	Alanine	14-21	protein tyrosine kinase 2 beta	Homo sapiens	56-59	
9568986-2	1998	Replacement of proline by alanine (ATK) in the PTK motif abolished transmission almost completely both from plants and from membranes.	Alanine	26-33	protein tyrosine kinase 2 beta	Homo sapiens	47-50