PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22688013-2	2012	The superoxide dismutase manganese dependent (SOD2) catalyzes O(2)(-) in H(2)O(2) into mitochondria and is encoded by a single gene that presents a common polymorphism that results in the replacement of alanine (A) with a valine (V) in the 16 codon.	Alanine	203-210	superoxide dismutase 2	Homo sapiens	46-50	
23315858-4	2013	We observed an association between MnSOD Ala/Ala frequency and a higher PCa risk.	Alanine	41-44	superoxide dismutase 2	Homo sapiens	35-40	
23315858-4	2013	We observed an association between MnSOD Ala/Ala frequency and a higher PCa risk.	Alanine	45-48	superoxide dismutase 2	Homo sapiens	35-40	
23315858-7	2013	The results of our study suggest that MnSOD Ala/Ala genotype may influence on early-onset of PCa patients, but no effect on subsequent development of the disease in Turkish men.	Alanine	44-47	superoxide dismutase 2	Homo sapiens	38-43	
23315858-7	2013	The results of our study suggest that MnSOD Ala/Ala genotype may influence on early-onset of PCa patients, but no effect on subsequent development of the disease in Turkish men.	Alanine	48-51	superoxide dismutase 2	Homo sapiens	38-43	
22704671-11	2012	CONCLUSIONS: The MnSOD Ala-9Val polymorphism causes susceptibility to recurrent tonsillitis in Turkish children.	Alanine	23-26	superoxide dismutase 2	Homo sapiens	17-22	
22825700-6	2012	Statistically significant increased risks were also identified in women with the MnSOD genotypes containing the Ala allele who had a tobacco smoking history (OR, 1.17; 95% CI, 1.02-1.34), a higher body mass index (OR, 1.26; 95% CI, 1.02-1.56) or who used oral contraceptives (OR, 1.98; 95% CI, 1.34-2.93).	Alanine	112-115	superoxide dismutase 2	Homo sapiens	81-86	
22432908-1	2012	OBJECTIVE: To check whether individual or combined mutated genotypes for Ala-9Val (Mn-SOD) and Arg213Gly (EC-SOD) are associated with preeclampsia; to check the influence of the mutated genotypes on the degree of severity and perinatal outcome of preeclampsia.	Alanine	73-76	superoxide dismutase 2	Homo sapiens	83-89	
21904836-7	2012	Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer.	Alanine	37-40	superoxide dismutase 2	Homo sapiens	48-53	
21904836-7	2012	Additionally, patients carrying both Ala/Ala of MnSOD and Leu/Leu of GPX1 had the highest risk of developing bladder cancer.	Alanine	41-44	superoxide dismutase 2	Homo sapiens	48-53	
21904836-9	2012	In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk.	Alanine	42-45	superoxide dismutase 2	Homo sapiens	36-41	
21904836-9	2012	In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk.	Alanine	46-49	superoxide dismutase 2	Homo sapiens	36-41	
21553226-8	2012	Ala/Ala genotype of MnSOD polymorphism may have an effect on adverse features of PCa such as high stage disease.	Alanine	0-3	superoxide dismutase 2	Homo sapiens	20-25	
22807932-11	2012	MnSOD gene polymorphism Ala/Val may be a risk factor associated with more advanced breast cancer stage, and reduction of MnSOD activity may be a mechanism of the progression of benign to malignant tumors.	Alanine	24-27	superoxide dismutase 2	Homo sapiens	0-5	
22699057-3	2012	Genotyping of the SNP Ala-9Val of MnSOD gene was performed by PCR and direct sequencing of the PCR products.	Alanine	22-25	superoxide dismutase 2	Homo sapiens	34-39	
21351093-11	2012	Patients carrying the high activity Ala/Ala genotype in SOD2 (rs4880) had significantly poorer PFS than Val allele carriers in the group treated by cyclophosphamide but not hormonal regimens (p = 0.004).	Alanine	36-39	superoxide dismutase 2	Homo sapiens	56-60	
21351093-11	2012	Patients carrying the high activity Ala/Ala genotype in SOD2 (rs4880) had significantly poorer PFS than Val allele carriers in the group treated by cyclophosphamide but not hormonal regimens (p = 0.004).	Alanine	40-43	superoxide dismutase 2	Homo sapiens	56-60	
21553226-8	2012	Ala/Ala genotype of MnSOD polymorphism may have an effect on adverse features of PCa such as high stage disease.	Alanine	4-7	superoxide dismutase 2	Homo sapiens	20-25	
21574139-4	2011	Alanine versus valine polymorphism in the signal peptide of the Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with the restriction enzyme NgoMIV.	Alanine	0-7	superoxide dismutase 2	Homo sapiens	64-70	
21130430-8	2011	The SOD2 Ala allele frequency was 49% both in controls and IVF patients.	Alanine	9-12	superoxide dismutase 2	Homo sapiens	4-8	
21062213-8	2011	Distribution of MnSOD genotypes was 47% Val/Val-variant, 29.5% Ala/Val and 23.5% Ala/Ala-variants.	Alanine	63-66	superoxide dismutase 2	Homo sapiens	16-21	
21062213-8	2011	Distribution of MnSOD genotypes was 47% Val/Val-variant, 29.5% Ala/Val and 23.5% Ala/Ala-variants.	Alanine	81-84	superoxide dismutase 2	Homo sapiens	16-21	
21062213-8	2011	Distribution of MnSOD genotypes was 47% Val/Val-variant, 29.5% Ala/Val and 23.5% Ala/Ala-variants.	Alanine	81-84	superoxide dismutase 2	Homo sapiens	16-21	
19467856-6	2009	However, we found that the MnSOD 9Ala allele was associated with an increased prostate cancer risk (Val/Ala versus Val/Val: odds ratio (OR)=1.1; 95% confidence intervals (CI): 1.0-1.3; Ala/Ala versus Val/Val: OR=1.3; 95% CI: 1.0-1.6; Val/Ala+Ala/Ala versus Val/Val: OR=1.2; 95% CI, 1.0-1.3).	Alanine	34-37	superoxide dismutase 2	Homo sapiens	27-32	
20478627-3	2010	The study examined the relationship between MnSOD gene polymorphisms (Ala-9Val, Ile-58Thr) and DD in the Polish population.	Alanine	70-73	superoxide dismutase 2	Homo sapiens	44-49	
20578157-6	2010	The SOD2 Ala/Ala genotype was associated with cholestatic/mixed damage (OR = 2.3; 95% confidence interval [CI] = 1.4-3.8; corrected P [Pc] = 0.0058), whereas the GPX1 Leu/Leu genotype was associated with cholestatic injury (OR = 5.1; 95%CI = 1.6-16.0; Pc = 0.0112).	Alanine	9-12	superoxide dismutase 2	Homo sapiens	4-8	
20578157-6	2010	The SOD2 Ala/Ala genotype was associated with cholestatic/mixed damage (OR = 2.3; 95% confidence interval [CI] = 1.4-3.8; corrected P [Pc] = 0.0058), whereas the GPX1 Leu/Leu genotype was associated with cholestatic injury (OR = 5.1; 95%CI = 1.6-16.0; Pc = 0.0112).	Alanine	13-16	superoxide dismutase 2	Homo sapiens	4-8	
20578157-7	2010	The presence of two or more combined risk alleles (SOD2 Ala and GPX1 Leu) was more frequent in DILI patients (OR = 2.1; 95%CI = 1.4-3.0; Pc = 0.0006).	Alanine	56-59	superoxide dismutase 2	Homo sapiens	51-55	
20578157-8	2010	Patients with cholestatic/mixed injury induced by mitochondria hazardous drugs were more prone to have the SOD2 Ala/Ala genotype (OR = 3.6; 95%CI = 1.4-9.3; Pc = 0.02).	Alanine	112-115	superoxide dismutase 2	Homo sapiens	107-111	
20578157-8	2010	Patients with cholestatic/mixed injury induced by mitochondria hazardous drugs were more prone to have the SOD2 Ala/Ala genotype (OR = 3.6; 95%CI = 1.4-9.3; Pc = 0.02).	Alanine	116-119	superoxide dismutase 2	Homo sapiens	107-111	
20578157-10	2010	CONCLUSION: Patients homozygous for the SOD2 Ala allele and the GPX1 Leu allele are at higher risk of developing cholestatic DILI.	Alanine	45-48	superoxide dismutase 2	Homo sapiens	40-44	
20346996-3	2010	METHODS: Genotyping was performed for the MnSOD gene Ala-9Val SNP in Chinese schizophrenia patients with (n=176) and without TD (n=346).	Alanine	53-56	superoxide dismutase 2	Homo sapiens	42-47	
20206073-9	2010	In healthy subjects the MnSOD genotype distribution was as follows: alanine/alanine 1.9%, alanine/valine 28.3%, and valine/valine 69.8%, and in VSA patients the prevalence was: alanine/alanine 1.3%, alanine/valine 19.3%, and valine/valine 79.4%.	Alanine	76-83	superoxide dismutase 2	Homo sapiens	24-29	
20206073-9	2010	In healthy subjects the MnSOD genotype distribution was as follows: alanine/alanine 1.9%, alanine/valine 28.3%, and valine/valine 69.8%, and in VSA patients the prevalence was: alanine/alanine 1.3%, alanine/valine 19.3%, and valine/valine 79.4%.	Alanine	76-83	superoxide dismutase 2	Homo sapiens	24-29	
20206073-9	2010	In healthy subjects the MnSOD genotype distribution was as follows: alanine/alanine 1.9%, alanine/valine 28.3%, and valine/valine 69.8%, and in VSA patients the prevalence was: alanine/alanine 1.3%, alanine/valine 19.3%, and valine/valine 79.4%.	Alanine	76-83	superoxide dismutase 2	Homo sapiens	24-29	
21619840-7	2011	SOD2 vitality in Ala(16) and Val(16) SOD2 transfected cells increased 2.51 and 2.71 times respectively (P < 0.01), but the difference between the two transfection groups was not statistically significant (P > 0.05).	Alanine	17-20	superoxide dismutase 2	Homo sapiens	0-4	
20931825-18	2010	In the group of patients with COPD, Val/Val genotype at position 9 of MnSOD signal peptide is associated with more severe depression, anxiety as a trait and anxiety as a state in comparison with patients who have Val/Ala and Ala/Ala genotypes.	Alanine	217-220	superoxide dismutase 2	Homo sapiens	70-75	
20931825-18	2010	In the group of patients with COPD, Val/Val genotype at position 9 of MnSOD signal peptide is associated with more severe depression, anxiety as a trait and anxiety as a state in comparison with patients who have Val/Ala and Ala/Ala genotypes.	Alanine	225-228	superoxide dismutase 2	Homo sapiens	70-75	
20931825-18	2010	In the group of patients with COPD, Val/Val genotype at position 9 of MnSOD signal peptide is associated with more severe depression, anxiety as a trait and anxiety as a state in comparison with patients who have Val/Ala and Ala/Ala genotypes.	Alanine	225-228	superoxide dismutase 2	Homo sapiens	70-75	
20501330-6	2010	CONCLUSION: The higher Ala-allele carrier rate among PD subjects may suggest a possible higher amount of mitochondrial Mn-SOD rendering higher intracellular stress in PD.	Alanine	23-26	superoxide dismutase 2	Homo sapiens	119-125	
20012093-10	2010	CONCLUSIONS: This meta-analysis suggests that the Ala allele of the MnSOD gene was a low-penetrance susceptible gene in PCA development, especially in Caucasians.	Alanine	50-53	superoxide dismutase 2	Homo sapiens	68-73	
20206073-3	2010	There are two genetic variants of MnSOD arising from a substitution of an alanine for a valine in the signal peptide.	Alanine	74-81	superoxide dismutase 2	Homo sapiens	34-39	
20206073-9	2010	In healthy subjects the MnSOD genotype distribution was as follows: alanine/alanine 1.9%, alanine/valine 28.3%, and valine/valine 69.8%, and in VSA patients the prevalence was: alanine/alanine 1.3%, alanine/valine 19.3%, and valine/valine 79.4%.	Alanine	68-75	superoxide dismutase 2	Homo sapiens	24-29	
20206073-9	2010	In healthy subjects the MnSOD genotype distribution was as follows: alanine/alanine 1.9%, alanine/valine 28.3%, and valine/valine 69.8%, and in VSA patients the prevalence was: alanine/alanine 1.3%, alanine/valine 19.3%, and valine/valine 79.4%.	Alanine	76-83	superoxide dismutase 2	Homo sapiens	24-29	
20206073-9	2010	In healthy subjects the MnSOD genotype distribution was as follows: alanine/alanine 1.9%, alanine/valine 28.3%, and valine/valine 69.8%, and in VSA patients the prevalence was: alanine/alanine 1.3%, alanine/valine 19.3%, and valine/valine 79.4%.	Alanine	76-83	superoxide dismutase 2	Homo sapiens	24-29	
19929244-5	2010	The MnSOD Ala/Ala and CAT TT genotypes were more frequent in HCC than in control (p = 0.001 and p = 0.072, respectively).	Alanine	10-13	superoxide dismutase 2	Homo sapiens	4-9	
19929244-5	2010	The MnSOD Ala/Ala and CAT TT genotypes were more frequent in HCC than in control (p = 0.001 and p = 0.072, respectively).	Alanine	14-17	superoxide dismutase 2	Homo sapiens	4-9	
19929244-7	2010	Combined MnSOD Ala/Ala and GPx1 Leu/Leu had a synergistic effect on HCC risk, with an OR of 3.84 (p = 0.029).	Alanine	15-18	superoxide dismutase 2	Homo sapiens	9-14	
19929244-7	2010	Combined MnSOD Ala/Ala and GPx1 Leu/Leu had a synergistic effect on HCC risk, with an OR of 3.84 (p = 0.029).	Alanine	19-22	superoxide dismutase 2	Homo sapiens	9-14	
19929244-8	2010	Furthermore an even more pronounced risk was observed when we combined MnSOD Ala/Ala and CAT TT (OR = 13.60, p = 0.023).	Alanine	77-80	superoxide dismutase 2	Homo sapiens	71-76	
19467856-6	2009	However, we found that the MnSOD 9Ala allele was associated with an increased prostate cancer risk (Val/Ala versus Val/Val: odds ratio (OR)=1.1; 95% confidence intervals (CI): 1.0-1.3; Ala/Ala versus Val/Val: OR=1.3; 95% CI: 1.0-1.6; Val/Ala+Ala/Ala versus Val/Val: OR=1.2; 95% CI, 1.0-1.3).	Alanine	104-107	superoxide dismutase 2	Homo sapiens	27-32	
19467856-6	2009	However, we found that the MnSOD 9Ala allele was associated with an increased prostate cancer risk (Val/Ala versus Val/Val: odds ratio (OR)=1.1; 95% confidence intervals (CI): 1.0-1.3; Ala/Ala versus Val/Val: OR=1.3; 95% CI: 1.0-1.6; Val/Ala+Ala/Ala versus Val/Val: OR=1.2; 95% CI, 1.0-1.3).	Alanine	104-107	superoxide dismutase 2	Homo sapiens	27-32	
19467856-6	2009	However, we found that the MnSOD 9Ala allele was associated with an increased prostate cancer risk (Val/Ala versus Val/Val: odds ratio (OR)=1.1; 95% confidence intervals (CI): 1.0-1.3; Ala/Ala versus Val/Val: OR=1.3; 95% CI: 1.0-1.6; Val/Ala+Ala/Ala versus Val/Val: OR=1.2; 95% CI, 1.0-1.3).	Alanine	104-107	superoxide dismutase 2	Homo sapiens	27-32	
19467856-6	2009	However, we found that the MnSOD 9Ala allele was associated with an increased prostate cancer risk (Val/Ala versus Val/Val: odds ratio (OR)=1.1; 95% confidence intervals (CI): 1.0-1.3; Ala/Ala versus Val/Val: OR=1.3; 95% CI: 1.0-1.6; Val/Ala+Ala/Ala versus Val/Val: OR=1.2; 95% CI, 1.0-1.3).	Alanine	104-107	superoxide dismutase 2	Homo sapiens	27-32	
19467856-6	2009	However, we found that the MnSOD 9Ala allele was associated with an increased prostate cancer risk (Val/Ala versus Val/Val: odds ratio (OR)=1.1; 95% confidence intervals (CI): 1.0-1.3; Ala/Ala versus Val/Val: OR=1.3; 95% CI: 1.0-1.6; Val/Ala+Ala/Ala versus Val/Val: OR=1.2; 95% CI, 1.0-1.3).	Alanine	104-107	superoxide dismutase 2	Homo sapiens	27-32	
19467856-7	2009	In addition, we found that the MnSOD Ala-9Ala genotype contributed to an increased breast cancer risk in premenopausal women who had low consumption of antioxidants (Ala/Ala versus Val/Ala+Val/Val: OR=2.6, 95% CI: 1.0-6.4 with low vitamin C consumption; OR=2.1, 95%CI: 1.3-3.4 with low vitamin E consumption and OR=2.9, 95%CI: 1.5-5.7 with low carotenoid consumption).	Alanine	37-40	superoxide dismutase 2	Homo sapiens	31-36	
19467856-7	2009	In addition, we found that the MnSOD Ala-9Ala genotype contributed to an increased breast cancer risk in premenopausal women who had low consumption of antioxidants (Ala/Ala versus Val/Ala+Val/Val: OR=2.6, 95% CI: 1.0-6.4 with low vitamin C consumption; OR=2.1, 95%CI: 1.3-3.4 with low vitamin E consumption and OR=2.9, 95%CI: 1.5-5.7 with low carotenoid consumption).	Alanine	42-45	superoxide dismutase 2	Homo sapiens	31-36	
19467856-7	2009	In addition, we found that the MnSOD Ala-9Ala genotype contributed to an increased breast cancer risk in premenopausal women who had low consumption of antioxidants (Ala/Ala versus Val/Ala+Val/Val: OR=2.6, 95% CI: 1.0-6.4 with low vitamin C consumption; OR=2.1, 95%CI: 1.3-3.4 with low vitamin E consumption and OR=2.9, 95%CI: 1.5-5.7 with low carotenoid consumption).	Alanine	42-45	superoxide dismutase 2	Homo sapiens	31-36	
19509150-2	2009	A functional single-nucleotide polymorphism in codon 16 of SOD2 (rs4880), which encodes manganese superoxide dismutase, results in a substitution of valine by alanine (Val16Ala).	Alanine	159-166	superoxide dismutase 2	Homo sapiens	59-63	
18760346-1	2008	The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity.	Alanine	38-45	superoxide dismutase 2	Homo sapiens	111-141	
18553161-10	2009	Even though the frequency of the Ala allele was low (9.6%) in the studied population, these data support the hypothesis that MnSOD and oxidative stress play a significant role in breast cancer risk both in males and females and also brings new information on the role of this polymorphism in prostate cancer.	Alanine	33-36	superoxide dismutase 2	Homo sapiens	125-130	
19636420-7	2009	Asbestosis was associated with the homozygous SOD2 - 9Ala/Ala genotype (OR = 1.50, 95% CI 1.01-2.24), whereas the association for the SOD3 Arg/Gly genotype was not significant (OR = 1.63, 95% CI 0.62-4.27).	Alanine	54-57	superoxide dismutase 2	Homo sapiens	46-50	
18784358-2	2008	The MnSOD allele with Val as amino acid 16 encodes a protein that has 30-40% lower activity compared with the MnSOD Ala variant, hence possibly increasing susceptibility to oxidative stress.	Alanine	116-119	superoxide dismutase 2	Homo sapiens	4-9	
18784358-2	2008	The MnSOD allele with Val as amino acid 16 encodes a protein that has 30-40% lower activity compared with the MnSOD Ala variant, hence possibly increasing susceptibility to oxidative stress.	Alanine	116-119	superoxide dismutase 2	Homo sapiens	110-115	
18784358-10	2008	However, men with the MnSOD Ala/Ala genotype who had low long-term lycopene status had a higher risk of aggressive prostate cancer compared with individuals with the other genotypes.	Alanine	28-31	superoxide dismutase 2	Homo sapiens	22-27	
18784358-10	2008	However, men with the MnSOD Ala/Ala genotype who had low long-term lycopene status had a higher risk of aggressive prostate cancer compared with individuals with the other genotypes.	Alanine	32-35	superoxide dismutase 2	Homo sapiens	22-27	
18784358-11	2008	These results are consistent with findings from earlier studies that reported when antioxidant status is low, the MnSOD Ala/Ala genotype may be associated with an increased risk of aggressive prostate cancer.	Alanine	120-123	superoxide dismutase 2	Homo sapiens	114-119	
18784358-11	2008	These results are consistent with findings from earlier studies that reported when antioxidant status is low, the MnSOD Ala/Ala genotype may be associated with an increased risk of aggressive prostate cancer.	Alanine	124-127	superoxide dismutase 2	Homo sapiens	114-119	
18760346-1	2008	The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity.	Alanine	38-45	superoxide dismutase 2	Homo sapiens	143-148	
18760346-1	2008	The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity.	Alanine	38-45	superoxide dismutase 2	Homo sapiens	161-166	
18760346-1	2008	The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity.	Alanine	4-7	superoxide dismutase 2	Homo sapiens	111-141	
18760346-1	2008	The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity.	Alanine	4-7	superoxide dismutase 2	Homo sapiens	143-148	
18760346-1	2008	The Ala/16Val dimorphism incorporates alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), modifying MnSOD mitochondrial import and activity.	Alanine	4-7	superoxide dismutase 2	Homo sapiens	161-166	
18646267-5	2008	A T-->C single nucleotide substitution, resulting in a Val-->Ala change at position 9 (Ala-9Val), which alters the secondary structure of the protein, has been noted to affect transport of MnSOD into the mitochondria.	Alanine	67-70	superoxide dismutase 2	Homo sapiens	195-200	
18646267-5	2008	A T-->C single nucleotide substitution, resulting in a Val-->Ala change at position 9 (Ala-9Val), which alters the secondary structure of the protein, has been noted to affect transport of MnSOD into the mitochondria.	Alanine	93-96	superoxide dismutase 2	Homo sapiens	195-200	
18683149-7	2008	CONCLUSION: The Ala(-9)Val polymorphism in the Mn-SOD gene may not be related to the etiology of type 2 diabetes, but it seems to contribute to the development of diabetic retinopathy in Chinese type 2 diabetic patients.	Alanine	16-19	superoxide dismutase 2	Homo sapiens	47-53	
18682580-5	2008	There was also indication of increased acoustic neuroma risk with the SOD2 rs4880 Ala variant (OR(CT/CC)=2.0; 95% CI, 1.0-4.2) and decreased acoustic neuroma risk with the CAT rs1001179 T allele variant (OR(CT/TT)=0.6; 95% CI, 0.3-1.0).	Alanine	82-85	superoxide dismutase 2	Homo sapiens	70-74	
17967822-8	2008	The association of the MnSOD polymorphism with CAD was investigated using blood samples collected from 498 CAD patients and 627 healthy subjects; the alanine allele was found to reduce the risk of CAD and acute myocardial infarction (AMI).	Alanine	150-157	superoxide dismutase 2	Homo sapiens	23-28	
17967822-3	2008	We investigated the associations of the MnSOD polymorphism (valine-to-alanine in the mitochondrial-targeting domain) with its activity in leukocytes, with macrophage apoptosis by oxidized low-density lipoprotein (oxLDL), and with coronary artery disease (CAD).	Alanine	70-77	superoxide dismutase 2	Homo sapiens	40-45	
17967822-5	2008	The mitochondrial MnSOD activities in leukocytes were 542.4 +/- 71.6 U/mg protein (alanine/alanine, n = 2), 302.0 +/- 94.9 U/mg protein (alanine/valine, n = 12), and 134.0 +/- 67.1 U/mg protein (valine/valine, n = 36; P < 0.0001 for non-valine/valine vs. valine/valine).	Alanine	83-90	superoxide dismutase 2	Homo sapiens	18-23	
17967822-5	2008	The mitochondrial MnSOD activities in leukocytes were 542.4 +/- 71.6 U/mg protein (alanine/alanine, n = 2), 302.0 +/- 94.9 U/mg protein (alanine/valine, n = 12), and 134.0 +/- 67.1 U/mg protein (valine/valine, n = 36; P < 0.0001 for non-valine/valine vs. valine/valine).	Alanine	91-98	superoxide dismutase 2	Homo sapiens	18-23	
17967822-5	2008	The mitochondrial MnSOD activities in leukocytes were 542.4 +/- 71.6 U/mg protein (alanine/alanine, n = 2), 302.0 +/- 94.9 U/mg protein (alanine/valine, n = 12), and 134.0 +/- 67.1 U/mg protein (valine/valine, n = 36; P < 0.0001 for non-valine/valine vs. valine/valine).	Alanine	91-98	superoxide dismutase 2	Homo sapiens	18-23	
17967822-9	2008	CONCLUSION: Our data indicate that the alanine variant of signal peptide increases the mitochondrial MnSOD activity, protects macrophages against the oxLDL-induced apoptosis, and reduces the risk of CAD and AMI.	Alanine	39-46	superoxide dismutase 2	Homo sapiens	101-106	
17336594-1	2007	BACKGROUND & AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import and activity.	Alanine	63-70	superoxide dismutase 2	Homo sapiens	136-166	
18023606-5	2008	A valine (Val) to alanine (Ala) substitution at amino acid 9, mapping within the mitochondrion-targeting sequence of the MnSOD gene, has been associated with an increased cancer risk.	Alanine	18-25	superoxide dismutase 2	Homo sapiens	121-126	
18023606-5	2008	A valine (Val) to alanine (Ala) substitution at amino acid 9, mapping within the mitochondrion-targeting sequence of the MnSOD gene, has been associated with an increased cancer risk.	Alanine	27-30	superoxide dismutase 2	Homo sapiens	121-126	
17628794-4	2007	A valine (Val) to alanine (Ala) substitution at amino acid 16, occurring in the mitochondrial targeting sequence of the MnSOD gene, has been associated with an increase in urolithiasis risk.	Alanine	18-25	superoxide dismutase 2	Homo sapiens	120-125	
17628794-4	2007	A valine (Val) to alanine (Ala) substitution at amino acid 16, occurring in the mitochondrial targeting sequence of the MnSOD gene, has been associated with an increase in urolithiasis risk.	Alanine	27-30	superoxide dismutase 2	Homo sapiens	120-125	
17646272-5	2007	The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03).	Alanine	20-23	superoxide dismutase 2	Homo sapiens	35-39	
17646272-5	2007	The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03).	Alanine	199-202	superoxide dismutase 2	Homo sapiens	35-39	
17646272-5	2007	The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03).	Alanine	199-202	superoxide dismutase 2	Homo sapiens	35-39	
17646272-5	2007	The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03).	Alanine	199-202	superoxide dismutase 2	Homo sapiens	35-39	
17646272-6	2007	Stratification by quartiles of dietary and supplemental vitamin E intake (IU/d) showed risks of prostate cancer tended to be increased among SOD2 Ala allele carriers, except at the highest quartile of vitamin E intake (>222; P(interaction) = 0.06, Q1-Q3 versus Q4).	Alanine	146-149	superoxide dismutase 2	Homo sapiens	141-145	
17646272-9	2007	These results suggest that the Ala variant of SOD2 is associated with moderately increased risk of prostate cancer, particularly among men with lower intakes of dietary and supplemental vitamin E.	Alanine	31-34	superoxide dismutase 2	Homo sapiens	46-50	
17336594-1	2007	BACKGROUND & AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import and activity.	Alanine	63-70	superoxide dismutase 2	Homo sapiens	168-173	
17336594-1	2007	BACKGROUND & AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import and activity.	Alanine	72-75	superoxide dismutase 2	Homo sapiens	136-166	
17336594-1	2007	BACKGROUND & AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import and activity.	Alanine	72-75	superoxide dismutase 2	Homo sapiens	168-173	
17336594-9	2007	CONCLUSIONS: Contrary to previous findings in French alcoholic patients, the Ala-encoding MnSOD allele is represented equally in controls and patients with HCV-related cirrhosis, and it does not significantly influence the risks of liver iron overload, HCC, or death in these patients.	Alanine	77-80	superoxide dismutase 2	Homo sapiens	90-95	
17465268-9	2007	It was concluded that MnSOD Ala allele might be the cause of prostate cancer risk among alcohol users.	Alanine	28-31	superoxide dismutase 2	Homo sapiens	22-27	
17453961-2	2007	METHODS: Ala (GTT) or Val (GCT) polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with restriction enzyme NgoM IV.	Alanine	9-12	superoxide dismutase 2	Homo sapiens	70-76	
17192491-4	2007	The present study aimed to determine whether a valine/alanine polymorphism in MnSOD (V16A, rs4880), alone or in combination with smoking, can contribute to development of diabetic nephropathy in 1,510 Finnish and Swedish patients with type 1 diabetes.	Alanine	54-61	superoxide dismutase 2	Homo sapiens	78-83	
16807759-7	2006	Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.	Alanine	25-28	superoxide dismutase 2	Homo sapiens	53-57	
16626843-1	2006	This study examined the relationship between a MnSOD gene (MnSOD) polymorphism (Ala-9Val) and mood disorders such as major depressive disorder (MDD) and bipolar I disorder (BD).	Alanine	80-83	superoxide dismutase 2	Homo sapiens	47-52	
16626843-1	2006	This study examined the relationship between a MnSOD gene (MnSOD) polymorphism (Ala-9Val) and mood disorders such as major depressive disorder (MDD) and bipolar I disorder (BD).	Alanine	80-83	superoxide dismutase 2	Homo sapiens	59-64	
16543247-9	2006	In an analysis of manganese superoxide dismutase (SOD2 Val16Ala, rs1799725) Ala/Ala homozygotes, we observed moderately increased risks for B-cell lymphomas (OR=1.3, 95% CI=1.0-1.6; referent=Val/Val and Val/Ala) that was consistent across the B-cell subtypes.	Alanine	60-63	superoxide dismutase 2	Homo sapiens	50-54	
16543247-9	2006	In an analysis of manganese superoxide dismutase (SOD2 Val16Ala, rs1799725) Ala/Ala homozygotes, we observed moderately increased risks for B-cell lymphomas (OR=1.3, 95% CI=1.0-1.6; referent=Val/Val and Val/Ala) that was consistent across the B-cell subtypes.	Alanine	76-79	superoxide dismutase 2	Homo sapiens	50-54	
16543247-9	2006	In an analysis of manganese superoxide dismutase (SOD2 Val16Ala, rs1799725) Ala/Ala homozygotes, we observed moderately increased risks for B-cell lymphomas (OR=1.3, 95% CI=1.0-1.6; referent=Val/Val and Val/Ala) that was consistent across the B-cell subtypes.	Alanine	76-79	superoxide dismutase 2	Homo sapiens	50-54	
17822322-11	2007	Progression of the disease might be further modified by the presence of Ala/Ala genotype of the SOD2.	Alanine	72-75	superoxide dismutase 2	Homo sapiens	96-100	
17822322-11	2007	Progression of the disease might be further modified by the presence of Ala/Ala genotype of the SOD2.	Alanine	76-79	superoxide dismutase 2	Homo sapiens	96-100	
16933053-1	2006	OBJECTIVE: A functional polymorphism at codon 16 (Alanine-to-Valine) of manganese superoxide dismutase (MnSOD) has been hypothesized to increase the risk of breast cancer and to modify the effects of oxidative stress.	Alanine	50-57	superoxide dismutase 2	Homo sapiens	72-102	
16933053-1	2006	OBJECTIVE: A functional polymorphism at codon 16 (Alanine-to-Valine) of manganese superoxide dismutase (MnSOD) has been hypothesized to increase the risk of breast cancer and to modify the effects of oxidative stress.	Alanine	50-57	superoxide dismutase 2	Homo sapiens	104-109	
16084535-5	2006	In those with the MnSOD Val/Ala or Ala/Ala genotypes this regression coefficient was 1.480 (p=0.040), whereas for the MnSOD Val/Val genotype it was 0.088 (p=0.859).	Alanine	28-31	superoxide dismutase 2	Homo sapiens	18-23	
16084535-6	2006	The higher regression coefficient was obtained for the subject group with the MnSOD Val/Ala or Ala/Ala genotype in combination with the MPO G/G genotype (p=0.012).	Alanine	88-91	superoxide dismutase 2	Homo sapiens	78-83	
15951095-5	2005	A valine (Val) to alanine (Ala) substitution at amino acid -9, occurring in the MnSOD gene, has been associated with various disease risk.	Alanine	18-25	superoxide dismutase 2	Homo sapiens	80-85	
16847469-2	2006	In this study, we aim to investigate the manganese superoxide dismutase (MnSOD) polymorphism at nucleotide 47 as a result of the change of Ala to Val on the protein sequence in CPPS patients.	Alanine	139-142	superoxide dismutase 2	Homo sapiens	41-71	
16847469-2	2006	In this study, we aim to investigate the manganese superoxide dismutase (MnSOD) polymorphism at nucleotide 47 as a result of the change of Ala to Val on the protein sequence in CPPS patients.	Alanine	139-142	superoxide dismutase 2	Homo sapiens	73-78	
15951095-5	2005	A valine (Val) to alanine (Ala) substitution at amino acid -9, occurring in the MnSOD gene, has been associated with various disease risk.	Alanine	27-30	superoxide dismutase 2	Homo sapiens	80-85	
15951095-6	2005	The aim of our study was to investigate possible associations of the MnSOD 47 T>C genotype in exon 2 (Ala-9Val) and the 339 T>C genotype in exon 3 (Ile58Thr) with contact sensitization to PPD in humans in a case-control study.	Alanine	105-108	superoxide dismutase 2	Homo sapiens	69-74	
15933380-2	2005	Recent evidences suggest that a genetic dimorphism that encodes for either alanine or valine in superoxide dismutase (SOD2) is involved with oxidative stress.	Alanine	75-82	superoxide dismutase 2	Homo sapiens	118-122	
17491681-0	2005	Manganese superoxide dismutase alanine to valine polymorphism and risk of neuropathy and nephropathy in Egyptian type 1 diabetic patients.	Alanine	31-38	superoxide dismutase 2	Homo sapiens	0-30	
15864132-1	2005	A genetic dimorphism incorporates either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of manganese superoxide dismutase (MnSOD).	Alanine	41-48	superoxide dismutase 2	Homo sapiens	152-157	
15864132-1	2005	A genetic dimorphism incorporates either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of manganese superoxide dismutase (MnSOD).	Alanine	50-53	superoxide dismutase 2	Homo sapiens	152-157	
15864132-2	2005	The Ala-MTS confers a 40% higher MnSOD activity than the Val-MTS after import into isolated mitochondria in vitro.	Alanine	4-8	superoxide dismutase 2	Homo sapiens	33-38	
15864132-5	2005	The Ala-variant resulted in four-fold higher levels of the mature exogenous protein and MnSOD activity than the Val-variant.	Alanine	4-7	superoxide dismutase 2	Homo sapiens	88-93	
15864132-9	2005	Much larger differences in the activity of the human Val- and Ala-MnSOD variants are observed in whole cells rather than after import experiments performed in vitro.	Alanine	62-65	superoxide dismutase 2	Homo sapiens	66-71	
15765450-1	2005	BACKGROUND AND AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import.	Alanine	61-68	superoxide dismutase 2	Homo sapiens	134-164	
15781667-2	2005	A polymorphism [valine (V) --> alanine (A)] of manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, has been recently associated with prostate cancer.	Alanine	34-41	superoxide dismutase 2	Homo sapiens	50-80	
15781667-2	2005	A polymorphism [valine (V) --> alanine (A)] of manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, has been recently associated with prostate cancer.	Alanine	34-41	superoxide dismutase 2	Homo sapiens	82-87	
15765450-1	2005	BACKGROUND AND AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import.	Alanine	61-68	superoxide dismutase 2	Homo sapiens	166-171	
15765450-1	2005	BACKGROUND AND AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import.	Alanine	70-73	superoxide dismutase 2	Homo sapiens	134-164	
15765450-1	2005	BACKGROUND AND AIMS: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence of manganese superoxide dismutase (MnSOD), and modulates its mitochondrial import.	Alanine	70-73	superoxide dismutase 2	Homo sapiens	166-171	
15331175-3	2004	For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83).	Alanine	108-111	superoxide dismutase 2	Homo sapiens	77-81	
15386537-6	2005	When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferase COMT-L (V158M) genotypes, the risk for developing breast cancer was significantly increased in patients with a body mass index (BMI) greater than 24 kg m(-2) (OR: 1.42 (95%CI=1.04-1.93)).	Alanine	11-14	superoxide dismutase 2	Homo sapiens	5-10	
15589819-2	2004	METHODS: Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV.	Alanine	9-16	superoxide dismutase 2	Homo sapiens	65-71	
15331175-3	2004	For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55-6.83).	Alanine	112-115	superoxide dismutase 2	Homo sapiens	77-81	
15196853-5	2004	RESULTS: For SOD2, women with the TC (val/ala) or CC (ala/ala) genotypes were at increased risk [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1-4.0].	Alanine	42-45	superoxide dismutase 2	Homo sapiens	13-17	
15193990-9	2004	CONCLUSIONS: We have extended a method of SOD2 polymorphism (Ala-9Val) in mitochondrial sequence.	Alanine	61-64	superoxide dismutase 2	Homo sapiens	42-46	
15184255-3	2004	A valine (Val) to alanine (Ala) substitution at amino acid 16, occurring in the mitochondrial targeting sequence of the MnSOD gene, has been associated with an increase in breast cancer risk.	Alanine	18-25	superoxide dismutase 2	Homo sapiens	120-125	
15184255-3	2004	A valine (Val) to alanine (Ala) substitution at amino acid 16, occurring in the mitochondrial targeting sequence of the MnSOD gene, has been associated with an increase in breast cancer risk.	Alanine	27-30	superoxide dismutase 2	Homo sapiens	120-125	
15184255-8	2004	We did observe evidence that the MnSOD Ala allele may modify the relation of cigarette smoking with breast cancer risk.	Alanine	39-42	superoxide dismutase 2	Homo sapiens	33-38	
15247771-9	2004	CONCLUSIONS: The GPX1 Pro/Leu genotype may significantly increase the risk of bladder cancer and the increased risk may be modified by the Ala-9Val MnSOD polymorphism.	Alanine	139-142	superoxide dismutase 2	Homo sapiens	148-153	
15196853-5	2004	RESULTS: For SOD2, women with the TC (val/ala) or CC (ala/ala) genotypes were at increased risk [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1-4.0].	Alanine	54-57	superoxide dismutase 2	Homo sapiens	13-17	
15196853-5	2004	RESULTS: For SOD2, women with the TC (val/ala) or CC (ala/ala) genotypes were at increased risk [odds ratio (OR) 2.1, 95% confidence interval (CI) 1.1-4.0].	Alanine	54-57	superoxide dismutase 2	Homo sapiens	13-17	
15535847-3	2004	A T --> C substitution in the MnSOD gene results in a Val --> Ala change at the -9 position of the mitochondrial targeting sequence (Val-9Ala), which alters the protein secondary structure and thus affects transport of MnSOD into the mitochondria.	Alanine	68-71	superoxide dismutase 2	Homo sapiens	33-38	
15217492-5	2004	RESULTS: The odds ratio for MnSOD Ala/Ala versus any MnSOD Val genotypes was not elevated in African Americans (odds ratio = 0.9, 95% confidence interval = 0.7-1.2) or in whites (odds ratio = 1.0, 95% confidence interval = 0.8-1.2).	Alanine	34-37	superoxide dismutase 2	Homo sapiens	28-33	
15535847-3	2004	A T --> C substitution in the MnSOD gene results in a Val --> Ala change at the -9 position of the mitochondrial targeting sequence (Val-9Ala), which alters the protein secondary structure and thus affects transport of MnSOD into the mitochondria.	Alanine	68-71	superoxide dismutase 2	Homo sapiens	225-230	
12963120-1	2003	A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer.	Alanine	39-42	superoxide dismutase 2	Homo sapiens	97-127	
12963120-1	2003	A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer.	Alanine	39-42	superoxide dismutase 2	Homo sapiens	129-134	
12815947-0	2003	[Association of the SOD2 Ala(-9)Val and SOD3 Arg213Gly polymorphisms with diabetic polyneuropathy in patients with diabetes mellitus type 1].	Alanine	25-28	superoxide dismutase 2	Homo sapiens	20-24	
12948282-6	2003	RESULTS: Men homozygous for the MnSOD ala allele had a 70% increase in risk over men homozygous for the val allele (odds ratio, OR = 1.72, 95% confidence interval, CI = 0.96-3.08, p = 0.07).	Alanine	38-41	superoxide dismutase 2	Homo sapiens	32-37	
12948282-8	2003	Although there was no difference in the association with disease stage, men homozygous for MnSOD ala (compared to MnSOD val/val or val/ala) showed a three-fold risk increase for high-grade tumors (OR = 2.72, 95% CI: 1.15-6.40, p = 0.02).	Alanine	97-100	superoxide dismutase 2	Homo sapiens	91-96	
12948282-8	2003	Although there was no difference in the association with disease stage, men homozygous for MnSOD ala (compared to MnSOD val/val or val/ala) showed a three-fold risk increase for high-grade tumors (OR = 2.72, 95% CI: 1.15-6.40, p = 0.02).	Alanine	97-100	superoxide dismutase 2	Homo sapiens	114-119	
12948282-9	2003	CONCLUSION: These data suggest an effect of the MnSOD ala/ala genotype on the development of prostate cancer.	Alanine	54-57	superoxide dismutase 2	Homo sapiens	48-53	
12948282-9	2003	CONCLUSION: These data suggest an effect of the MnSOD ala/ala genotype on the development of prostate cancer.	Alanine	58-61	superoxide dismutase 2	Homo sapiens	48-53	
12618592-1	2003	A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of human manganese superoxide dismutase (MnSOD) and has been reported to modulate the risk of some cancers, neurodegenerative diseases and severe alcoholic liver disease.	Alanine	40-47	superoxide dismutase 2	Homo sapiens	125-155	
12618592-1	2003	A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of human manganese superoxide dismutase (MnSOD) and has been reported to modulate the risk of some cancers, neurodegenerative diseases and severe alcoholic liver disease.	Alanine	40-47	superoxide dismutase 2	Homo sapiens	157-162	
12618592-1	2003	A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of human manganese superoxide dismutase (MnSOD) and has been reported to modulate the risk of some cancers, neurodegenerative diseases and severe alcoholic liver disease.	Alanine	49-52	superoxide dismutase 2	Homo sapiens	125-155	
12618592-1	2003	A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of human manganese superoxide dismutase (MnSOD) and has been reported to modulate the risk of some cancers, neurodegenerative diseases and severe alcoholic liver disease.	Alanine	49-52	superoxide dismutase 2	Homo sapiens	157-162	
12447859-2	2002	Recently, it has been reported that homozygosity for a valine to alanine substitution in the mitochondrial targeting sequence of manganese superoxide dismutase (Mn-SOD) represents a risk factor for severe ALD.	Alanine	65-72	superoxide dismutase 2	Homo sapiens	129-159	
12683635-9	2003	In Mn-SOD mRNA, Val at -9 position was varied to Ala in lymphocytes from two donors and three OSC cell lines, respectively.	Alanine	49-52	superoxide dismutase 2	Homo sapiens	3-9	
12624725-1	2003	We evaluated the relationship of an alanine or valine polymorphism at amino acid sequence 16 [Val(16)Ala] of manganese superoxide dismutase (Mn-SOD) with diabetes and diabetic nephropathy in Japanese type 2 diabetic patients.	Alanine	36-43	superoxide dismutase 2	Homo sapiens	109-139	
12624725-1	2003	We evaluated the relationship of an alanine or valine polymorphism at amino acid sequence 16 [Val(16)Ala] of manganese superoxide dismutase (Mn-SOD) with diabetes and diabetic nephropathy in Japanese type 2 diabetic patients.	Alanine	36-43	superoxide dismutase 2	Homo sapiens	141-147	
12447859-2	2002	Recently, it has been reported that homozygosity for a valine to alanine substitution in the mitochondrial targeting sequence of manganese superoxide dismutase (Mn-SOD) represents a risk factor for severe ALD.	Alanine	65-72	superoxide dismutase 2	Homo sapiens	161-167	
12447859-4	2002	Genotyping for the valine-alanine (Val-Ala) polymorphism of the Mn-SOD gene in 281 patients with advanced ALD (cirrhosis/fibrosis) and 218 drinkers without liver disease showed no differences in either the heterozygote (55% vs. 50%) or the homozygote (19% vs. 23%) frequency for the alanine allele.	Alanine	26-33	superoxide dismutase 2	Homo sapiens	64-70	
11836586-1	2002	Recently a T to C substitution in the mitochondrial targeting sequence of the manganese superoxide dismutase (MnSOD) gene was observed that changes the amino acid sequence of the protein from valine (V) to alanine (A) and is associated with a decreased defense capacity against oxidative stress.	Alanine	206-213	superoxide dismutase 2	Homo sapiens	78-108	
12127599-2	2002	The manganese-containing form of this enzyme (MnSOD) is the major superoxide scavenger in mitochondria; a weak association between a functional genetic polymorphism (Ala-9Val) in the mitochondrial targeting sequence (MTS) of this enzyme and TD has been reported in a Japanese population.	Alanine	166-169	superoxide dismutase 2	Homo sapiens	46-51	
11836586-1	2002	Recently a T to C substitution in the mitochondrial targeting sequence of the manganese superoxide dismutase (MnSOD) gene was observed that changes the amino acid sequence of the protein from valine (V) to alanine (A) and is associated with a decreased defense capacity against oxidative stress.	Alanine	206-213	superoxide dismutase 2	Homo sapiens	110-115	
11313317-2	2001	A genetic dimorphism encodes for either alanine or valine in the mitochondrial targeting sequence of manganese superoxide dismutase and could modulate its mitochondrial import.	Alanine	40-47	superoxide dismutase 2	Homo sapiens	101-131	
11481695-5	2001	However, we identified a previously described polymorphism of the mitochondrial targeting sequence consisting of a C47T in exon 2 of SOD2, which results in an alanine to valine substitution.	Alanine	159-166	superoxide dismutase 2	Homo sapiens	133-137	
9371904-3	1997	We used a novel polymorphic mutation at -9 position of the signal peptide of the Mn SOD precursor protein, which caused valine to alanine substitution.	Alanine	130-137	superoxide dismutase 2	Homo sapiens	81-87	
11369207-13	2001	In contrast, an alanine substitution of the cysteine of the CAAX box has very little effect on Mn-SOD activity but eliminates ERK1/2- dependent transcription.	Alanine	16-23	superoxide dismutase 2	Homo sapiens	95-101	
11299047-11	2001	CONCLUSIONS: Ala(-9)Val substitution in the Mn-SOD gene was associated with DN in a Russian population	Alanine	13-16	superoxide dismutase 2	Homo sapiens	44-50	
10425186-4	1999	In addition, processing efficiency of Val-type SOD2 leader peptide in the presence of mitochondria was siginificantly lower than that of the Ala-type by 11 +/- 4%, suggesting that this lower processing efficiency was in part an underlying mechanism of the association between the SOD2-VV genotype and nonfamilial IDC.	Alanine	141-144	superoxide dismutase 2	Homo sapiens	47-51	
33535682-2	2021	Val16A (Ala) SOD2 polymorphism has been associated with increased prostate cancer (PCa) risk.	Alanine	8-11	superoxide dismutase 2	Homo sapiens	13-17	
33535682-3	2021	We hypothesized that SOD2 Ala single nucleotide polymorphism (SNP) may promote EMT.	Alanine	26-29	superoxide dismutase 2	Homo sapiens	21-25	
27141263-6	2016	This SNP changes the amino acid at position 16 from valine (Val) to alanine (Ala), which has been shown to cause a conformational change in the target sequence of manganese superoxide dismutase (MnSOD) and also affects MnSOD activity in mitochondria.	Alanine	68-75	superoxide dismutase 2	Homo sapiens	163-193	
30225256-9	2018	Results: The MnSOD Val/Ala+Ala/Ala genotype was significantly associated with an increased risk of CAD compared to the Val/Val genotype (OR = 1.86, 95% CI = 1.15-3.01).	Alanine	23-26	superoxide dismutase 2	Homo sapiens	13-18	
30225256-9	2018	Results: The MnSOD Val/Ala+Ala/Ala genotype was significantly associated with an increased risk of CAD compared to the Val/Val genotype (OR = 1.86, 95% CI = 1.15-3.01).	Alanine	27-30	superoxide dismutase 2	Homo sapiens	13-18	
30225256-9	2018	Results: The MnSOD Val/Ala+Ala/Ala genotype was significantly associated with an increased risk of CAD compared to the Val/Val genotype (OR = 1.86, 95% CI = 1.15-3.01).	Alanine	27-30	superoxide dismutase 2	Homo sapiens	13-18	
30225256-12	2018	Among cigarette smokers, the harmful genetic effect of MnSOD Ala allele on CAD risk was much higher (OR = 2.23, 95% CI = 1.02-4.88).	Alanine	61-64	superoxide dismutase 2	Homo sapiens	55-60	
29681991-8	2018	Results: The Ala allele of the MnSOD Val16Ala polymorphism was associated with a lower risk of CKD (odds ratio (OR), 0.55; 95% confidence interval (CI), 0.36-0.84; P = 0.006).	Alanine	13-16	superoxide dismutase 2	Homo sapiens	31-36	
29109056-6	2017	In ST group, post-training decrease in serum lipid hydroperoxides (p < 0.05) and creatine kinase activity (p < 0.05) was associated with Ala/Ala genotype of SOD2 Val16Ala polymorphism.	Alanine	143-146	superoxide dismutase 2	Homo sapiens	163-167	
29109056-6	2017	In ST group, post-training decrease in serum lipid hydroperoxides (p < 0.05) and creatine kinase activity (p < 0.05) was associated with Ala/Ala genotype of SOD2 Val16Ala polymorphism.	Alanine	147-150	superoxide dismutase 2	Homo sapiens	163-167	
28482710-8	2017	Moreover, multiple regression analysis demonstrated that SOD2 genotype was a significant predictor of pre-training whole blood GPx activity and erythrocyte SOD activity (Val/Val > Ala/Val > Ala/Ala).	Alanine	183-186	superoxide dismutase 2	Homo sapiens	57-61	
28482710-8	2017	Moreover, multiple regression analysis demonstrated that SOD2 genotype was a significant predictor of pre-training whole blood GPx activity and erythrocyte SOD activity (Val/Val > Ala/Val > Ala/Ala).	Alanine	183-186	superoxide dismutase 2	Homo sapiens	57-60	
28198160-10	2017	Smoking was a risk factor in the development of IS for CAT TT and MnSOD Ala/Val genotypes; we found a 3.5- to 5.5-fold higher IS risk in CAT TT and MnSOD Ala/Val genotypes.	Alanine	72-75	superoxide dismutase 2	Homo sapiens	66-71	
28198160-10	2017	Smoking was a risk factor in the development of IS for CAT TT and MnSOD Ala/Val genotypes; we found a 3.5- to 5.5-fold higher IS risk in CAT TT and MnSOD Ala/Val genotypes.	Alanine	154-157	superoxide dismutase 2	Homo sapiens	66-71	
28198160-10	2017	Smoking was a risk factor in the development of IS for CAT TT and MnSOD Ala/Val genotypes; we found a 3.5- to 5.5-fold higher IS risk in CAT TT and MnSOD Ala/Val genotypes.	Alanine	154-157	superoxide dismutase 2	Homo sapiens	148-153	
27055786-12	2016	CONCLUSIONS: This meta-analysis indicated that the Ala allele of the MnSOD gene polymorphism increases prostate cancer susceptibility.	Alanine	51-54	superoxide dismutase 2	Homo sapiens	69-74	
29113986-7	2018	In a preplanned exploratory analysis, PSADT pre-to-post increase was significant in the 27 (26%) genotyped patients with SOD2 Alanine/Alanine genotype (rs4880 T>C polymorphism) on MPX (pooled treatment arms; 6.4 months, P = 0.02), but not in control (1.8 months, P = 0.25).Conclusions: Compared with placebo, MPX did not significantly prolong PSADT in BCR patients over two different doses.	Alanine	126-133	superoxide dismutase 2	Homo sapiens	121-125	
28655148-4	2017	Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636.3:c.47 T > C, alanine (ALA) to valine (Val)] and in the CAT promoter region [rs1001179, NG_013339.1:g.4760 C > T].	Alanine	106-113	superoxide dismutase 2	Homo sapiens	59-64	
28655148-4	2017	Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636.3:c.47 T > C, alanine (ALA) to valine (Val)] and in the CAT promoter region [rs1001179, NG_013339.1:g.4760 C > T].	Alanine	115-118	superoxide dismutase 2	Homo sapiens	59-64	
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Alanine	334-341	superoxide dismutase 2	Homo sapiens	22-26	
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Alanine	334-341	superoxide dismutase 2	Homo sapiens	130-134	
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Alanine	334-341	superoxide dismutase 2	Homo sapiens	130-134	
28028182-7	2017	This study shows that SOD2 specifically binds to hsp70 at 445GERAMT450 Small peptides containing GERAMT inhibited the transfer of SOD2 to the mitochondria and decreased SOD2 activity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative residues, glutamine or asparagine, in the GERAMT-binding site.	Alanine	334-341	superoxide dismutase 2	Homo sapiens	130-134	
26882122-3	2016	In humans, there is a gene polymorphism where a change of alanine (Ala) to valine (Val) occurs at the 16th amino acid (Ala16Val-SOD2).	Alanine	58-65	superoxide dismutase 2	Homo sapiens	128-132	
26882122-3	2016	In humans, there is a gene polymorphism where a change of alanine (Ala) to valine (Val) occurs at the 16th amino acid (Ala16Val-SOD2).	Alanine	67-70	superoxide dismutase 2	Homo sapiens	128-132	
27325180-4	2016	The rs4880 encodes Ala16Val in SOD2 and the Val variant has been demonstrated to be functionally less efficient than the Ala variant.	Alanine	19-22	superoxide dismutase 2	Homo sapiens	31-35	
27141263-6	2016	This SNP changes the amino acid at position 16 from valine (Val) to alanine (Ala), which has been shown to cause a conformational change in the target sequence of manganese superoxide dismutase (MnSOD) and also affects MnSOD activity in mitochondria.	Alanine	68-75	superoxide dismutase 2	Homo sapiens	195-200	
27141263-6	2016	This SNP changes the amino acid at position 16 from valine (Val) to alanine (Ala), which has been shown to cause a conformational change in the target sequence of manganese superoxide dismutase (MnSOD) and also affects MnSOD activity in mitochondria.	Alanine	68-75	superoxide dismutase 2	Homo sapiens	219-224	
27141263-6	2016	This SNP changes the amino acid at position 16 from valine (Val) to alanine (Ala), which has been shown to cause a conformational change in the target sequence of manganese superoxide dismutase (MnSOD) and also affects MnSOD activity in mitochondria.	Alanine	77-80	superoxide dismutase 2	Homo sapiens	163-193	
27141263-6	2016	This SNP changes the amino acid at position 16 from valine (Val) to alanine (Ala), which has been shown to cause a conformational change in the target sequence of manganese superoxide dismutase (MnSOD) and also affects MnSOD activity in mitochondria.	Alanine	77-80	superoxide dismutase 2	Homo sapiens	195-200	
27141263-6	2016	This SNP changes the amino acid at position 16 from valine (Val) to alanine (Ala), which has been shown to cause a conformational change in the target sequence of manganese superoxide dismutase (MnSOD) and also affects MnSOD activity in mitochondria.	Alanine	77-80	superoxide dismutase 2	Homo sapiens	219-224	
26528342-8	2015	Furthermore, an overall protective effect of the Ala allele of the MnSOD polymorphism on PCa risk was detected.	Alanine	49-52	superoxide dismutase 2	Homo sapiens	67-72	
26400460-14	2015	The Ala variant, which has been associated with increased MnSOD activity, was associated with hearing damage in this study.	Alanine	4-7	superoxide dismutase 2	Homo sapiens	58-63	
25753816-3	2015	In humans, a single nucleotide polymorphism (SNP) is present in the enzyme manganese superoxide dismutase (SOD2), localized in codon 16 (rs4880), which can either be an alanine (A) or valine (V).	Alanine	169-176	superoxide dismutase 2	Homo sapiens	107-111	
25858271-4	2015	METHOD: 278 (136M:142F) T1DM patients and 135 (72M:63F) normal, healthy controls were investigated for SOD-2 polymorphism in the mitochondrial targeting sequence with Ala/Val (C-9T) substitution.	Alanine	167-170	superoxide dismutase 2	Homo sapiens	103-108	
25858271-10	2015	CONCLUSION: The SNP in SOD-2 results in a substitution of C to T, which causes an amino acid change from alanine to valine.	Alanine	105-112	superoxide dismutase 2	Homo sapiens	23-28	
25662905-6	2015	RESULTS: Among patients who underwent RT in the test cohort, there was a significant association between 3 of the 7 SOD2 SNPs and lethal prostate cancer: rs6917589 (overall P = .006), rs2758331 (P = .04) and the functional valine to alanine polymorphism in rs4880 (P = .04).	Alanine	233-240	superoxide dismutase 2	Homo sapiens	116-120	
23588476-10	2014	We demonstrated an association between the MnSOD Ala-9Val variant and poor attention in schizophrenia.	Alanine	49-52	superoxide dismutase 2	Homo sapiens	43-48	
25497738-8	2015	Evaluating the subgroup of 293 ICU patients with sepsis, a pooled analysis including two genetic variants GPx1 and SOD2 (47C>T SNP, rs4880; protein variant in MnSOD: Ala-9Val) showed a significant difference in relation to progression to septic shock.	Alanine	169-172	superoxide dismutase 2	Homo sapiens	115-119	
25497738-8	2015	Evaluating the subgroup of 293 ICU patients with sepsis, a pooled analysis including two genetic variants GPx1 and SOD2 (47C>T SNP, rs4880; protein variant in MnSOD: Ala-9Val) showed a significant difference in relation to progression to septic shock.	Alanine	169-172	superoxide dismutase 2	Homo sapiens	162-167	
24610415-5	2014	Patients with HCV and normal, healthy controls were investigated for a superoxide dismutase (SOD-2) polymorphism in the mitochondrial targeting sequence with Ala/Val (C-9T) substitution.	Alanine	158-161	superoxide dismutase 2	Homo sapiens	93-98	
25684475-6	2015	RESULTS: The frequencies of MnSOD Ala/Ala, Ala/Val and Val/Val genotypes in healthy individuals were 24.3, 66.7 and 9%, respectively.	Alanine	34-37	superoxide dismutase 2	Homo sapiens	28-33	
23991909-8	2013	We conclude that 1) the Ala allele is more frequent in athletes than in controls; and 2) the higher frequency of the Ala allele was noted in both endurance and power athletes compared with that in controls, suggesting that the positive association between the Ala allele and athletic performance may be related to ROS-related angiogenesis, mitochondrial biosynthesis, and muscle hypertrophy, and not to MnSOD aerobic properties.	Alanine	117-120	superoxide dismutase 2	Homo sapiens	403-408	
24587799-9	2014	There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039).	Alanine	125-128	superoxide dismutase 2	Homo sapiens	42-47	
24587799-9	2014	There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039).	Alanine	129-132	superoxide dismutase 2	Homo sapiens	42-47	
24587799-9	2014	There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039).	Alanine	129-132	superoxide dismutase 2	Homo sapiens	42-47	
23991909-8	2013	We conclude that 1) the Ala allele is more frequent in athletes than in controls; and 2) the higher frequency of the Ala allele was noted in both endurance and power athletes compared with that in controls, suggesting that the positive association between the Ala allele and athletic performance may be related to ROS-related angiogenesis, mitochondrial biosynthesis, and muscle hypertrophy, and not to MnSOD aerobic properties.	Alanine	117-120	superoxide dismutase 2	Homo sapiens	403-408	
23123399-8	2013	Among them, manganese superoxide dismutase gene Ala-9Val polymorphisms show a relatively consistent association with TD susceptibility, although not all studies support this.	Alanine	48-51	superoxide dismutase 2	Homo sapiens	12-42	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	114-117	superoxide dismutase 2	Homo sapiens	109-113	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	114-117	superoxide dismutase 2	Homo sapiens	161-165	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	118-121	superoxide dismutase 2	Homo sapiens	109-113	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	118-121	superoxide dismutase 2	Homo sapiens	109-113	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	118-121	superoxide dismutase 2	Homo sapiens	109-113	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	118-121	superoxide dismutase 2	Homo sapiens	109-113	
23967348-6	2013	Both the significant adjusted OR of 4.30 (95% CI, 1.23-15.03) and 4.53 (95% CI, 1.52-13.51) were observed in SOD2 Ala/Ala and Val/Ala compared to Val/Val and in SOD2 Ala/Ala compared to Val/Ala compared to Val/Val genetic analysis in the high chemical sensitivity case-control study.	Alanine	118-121	superoxide dismutase 2	Homo sapiens	109-113