PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16162643-3	2005	Alanine substitution of lysine residues demonstrated that two out of six lysine residues, Lys13 and Lys96, are required for lysozyme sweetness, while the remaining four lysine residues do not play a significant role in the perception of sweetness.	Alanine	0-7	lysozyme	Homo sapiens	124-132	
18029788-2	2007	The genes coding chicken lysozyme signal peptide - human lysozyme (HLY) hybrid preproteins were altered as follows: -2Leu to Pro and -lGly to either Ala, Val, Leu, Asn or Lys, and were expressed in yeast cells.	Alanine	149-152	lysozyme	Homo sapiens	25-33	
18029788-2	2007	The genes coding chicken lysozyme signal peptide - human lysozyme (HLY) hybrid preproteins were altered as follows: -2Leu to Pro and -lGly to either Ala, Val, Leu, Asn or Lys, and were expressed in yeast cells.	Alanine	149-152	lysozyme	Homo sapiens	57-65	
16162643-5	2005	Single alanine substitutions of arginine residues showed that three arginine residues, Arg14, Arg21, and Arg73, play significant roles in lysozyme sweetness, whereas Arg45, Arg68, Arg125 and chemical modification by 1,2-cyclohexanedione did not affect sweetness.	Alanine	7-14	lysozyme	Homo sapiens	138-146	
14217885-2	1964	CHARACTERIZATION OF AN ALANINE-CONTAINING GLUCOSAMINYLMURAMIC ACID DERIVATIVE LIBERATED BY LYSOZYME FROM STREPTOCOCCAL GLYCOPEPTIDE.	Alanine	23-30	lysozyme	Homo sapiens	91-99	
2040307-1	1991	To investigate the mechanism of disulfide-bond-coupled de novo folding of human lysozyme, we have constructed 23 mutant enzymes in which cysteine residue(s) were replaced by alanine(s).	Alanine	174-181	lysozyme	Homo sapiens	80-88	
10810162-2	2000	P. pastoris expressed the human lysozyme at about 300 mg/l broth, but four extra residues (Glu(-4)-Ala(-3)-Glu(-2)-Ala(-1)-) were added at the N-terminus of the expressed protein (EAEA-lysozyme).	Alanine	99-102	lysozyme	Homo sapiens	32-40	
10810162-2	2000	P. pastoris expressed the human lysozyme at about 300 mg/l broth, but four extra residues (Glu(-4)-Ala(-3)-Glu(-2)-Ala(-1)-) were added at the N-terminus of the expressed protein (EAEA-lysozyme).	Alanine	115-118	lysozyme	Homo sapiens	32-40	
2674939-1	1989	A Ca2+ binding site like an EF-hand motif was designed and created in human lysozyme by replacing both Gln-86 and Ala-92 with aspartic acids by site-directed mutagenesis.	Alanine	114-117	lysozyme	Homo sapiens	76-84	
20582913-0	2010	Improved antimicrobial activity of h-lysozyme (107-115) by rational Ala substitution.	Alanine	68-71	lysozyme	Homo sapiens	37-45	
20582913-4	2010	Taking the fragment 107-115 of the human lysozyme as lead, two-round screening by sequentially replacing both Ala residues (108 and 111) by distinct amino acids resulted in a novel peptide with 4- and 20-fold increased antimicrobial activity against Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213, respectively.	Alanine	110-113	lysozyme	Homo sapiens	41-49