PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35264812-3 2022 Most compounds exhibited potent BRD4 binding activities with DeltaTm values exceeding 6 C. Two crystal structures of 11h and 11r in complex with BRD4(1) were obtained to characterize the binding patterns. 2,6-disulfonic acid anthraquinone 118-121 bromodomain containing 4 Homo sapiens 32-36 35264812-3 2022 Most compounds exhibited potent BRD4 binding activities with DeltaTm values exceeding 6 C. Two crystal structures of 11h and 11r in complex with BRD4(1) were obtained to characterize the binding patterns. 2,6-disulfonic acid anthraquinone 118-121 bromodomain containing 4 Homo sapiens 146-150 35264812-4 2022 Compounds 11h and 11r were effective for BRD4(1) binding and showed remarkable anti-proliferative activity against MV4-11 cells with IC50 values of 0.78 and 0.87 muM. 2,6-disulfonic acid anthraquinone 10-13 bromodomain containing 4 Homo sapiens 41-45